Gastroenteritis Viruses

This important book covers the structure and molecular biology of small round structured viruses (SSRVs) such as caliciviruses and astroviruses, and the basic pathology of infection. It provides readers with the knowledge needed to make progress in the prevention and treatment of these infections. Readers will also find an overview of gastroentitis vaccines, their structure and molecular biology, as well as the basic pathology of infection, epidemiology and surveillance.

• Provides an interdisciplinary approach, offering contributions from basic and clinical research
• Discusses the prevention and treatment of regimes
• Includes an overview of gastroentitis vaccines

Ein modernes Thema - vor allem angesichts der Entwicklung eines Rotavirus-Impfstoffs und der Identifizierung zahlreicher neuer Gastroenteritis-Viren. Beschrieben werden Struktur und Molekularbiologie der SSRVs wie Caliciviren und Astroviren sowie Aspekte der Pathologie der Infektion. Der interdisziplinäre Ansatz faßt Ergebnisse aus der Grundlagen- und der klinischen Forschung zusammen. Introduction (M. Estes).

Gastroenteritis Viruses: An Overview (R. Glass, et al.).

Structural Studies on Gastroenteritis Viruses (B. Prasad, et al.).

Early Events of Rotavirus Infection: The Search for the Receptor(s) (C. Arias, et al.).

Rotavirus RNA Replication and Gene Expression (J. Patton).

Pathogenesis of Rotavirus Gastroenteritis (M. Estes, et al.).

Correlates of Protection Against Rotavirus Infection and Disease (P. Offit).

Rotavirus Epidemiology and Surveillance (U. Desselberger, et al.).

A Rotavirus Vaccine for Prevention of Severe Diarrhoea of Infants and Young Children: Development, Utilization and Withdrawal (A. Kapikian).

The Molecular Biology of Human Caliciviruses (I. Clarke & P. Lambden).

Molecular Epidemiology of Human Enteric Caliciviruses in The Netherlands (M. Koopmans, et al.).

Molecular Biology of Astroviruses: Selected Highlights (S. Matsui, et al.).

Molecular Epidemiology of Human Astroviruses (S. Monroe, et al.).

Enteric Infections with Coronaviruses and Toroviruses (K. Holmes).

Viruses Causing Diarrhoea in AIDS (R. Pollok).

Treatment of Gestrointestinal Viruses (M. Farthing).

Summing-Up (M. Estes).

Index of Contributors.

Subject Index.

Derek J. Chadwick and Jamie A. Goode are editors for Gastroenteritis Viruses and other scientific titles.

Gastroenteritis viruses are a major cause of morbidity and mortality in humans. Many hundreds of thousands of children die annually from rotavirus diarrhoea in the developing world, and although in industrialized countries rotavieus infection is rarely fatal, the economic burden of the disease is substantial. Human caliciviruses have emerged as a significant cause of viral gastroenteritis globally. This book contains presentations and discussions by internationally recognized experts on virus structure, replication, pathogenesis, immune response and correlates of protection, molecular-epidemiological surveillance, advances in treatment, and efforts to develop vaccines, particularly against rotavirus disease. The spectrum of viruses covered comprises rotaviruses, human caliciviruses, astroviruses, coronaviruses and viruses causing gut disease in the immunocompromized host. The book not only conveys facts but also gives ample room to lively discussions on many issues at the forefront of research and development.