{"product_id":"fundamental-neuropathology-for-pathologists-and-toxicologists-isbn-9780470227336","title":"Fundamental Neuropathology for Pathologists and Toxicologists","description":"This book offers pathologists, toxicologists, other medical professionals, and students an introduction to the discipline and techniques of neuropathology – including chemical and environmental, biological, medical, and regulatory details important for performing an analysis of toxicant-induced neurodiseases. In addition to a section on fundamentals, the book provides detailed coverage of current practices (bioassays, molecular analysis, and nervous system pathology) and practical aspects (data interpretation, regulatory considerations, and tips for preparing reports).  Editors’ Preface.  \u003cp\u003eForward.\u003c\/p\u003e \u003cp\u003eAcknowledgments.\u003c\/p\u003e \u003cp\u003ePart I. Fundamentals of Neurobiology.\u003c\/p\u003e \u003cp\u003eChapter 1. Fundamentals of Toxicologic Neuropathology: An Introduction.\u003c\/p\u003e \u003cp\u003eChapter 2. Functional Neuroanatomy.\u003c\/p\u003e \u003cp\u003eChapter 3. Atlas of Comparative Neuroanatomy.\u003c\/p\u003e \u003cp\u003eChapter 4. Principles of Comparative and Correlative Neurodevelopment, and their Implications for Developmental Neurotoxicity.\u003c\/p\u003e \u003cp\u003eChapter 5. Localizing Neuropathologic Lesions Using Neurologic Findings.\u003c\/p\u003e \u003cp\u003eChapter 6. Behavioral Model Systems for Evaluating Neuropathology.\u003c\/p\u003e \u003cp\u003eChapter 7. Cognitive Assessments in Non-Human Primates.\u003c\/p\u003e \u003cp\u003eChapter 8. The Impact of Aging on Brain Structure and Function in Rodents and Canines.\u003c\/p\u003e \u003cp\u003eChapter 9. Fundamentals of Neurotoxicity Detection.\u003c\/p\u003e \u003cp\u003ePart 2. Toxicologic Neuropathology: Methodology.\u003c\/p\u003e \u003cp\u003eChapter 10. Practical Neuropathology of the Rat and Other Species.\u003c\/p\u003e \u003cp\u003eChapter 11. The Fluoro-Jade Dyes: Novel, Sensitive, and Reliable Fluorochromes for the Histochemical Localization of Degenerating Neurons.\u003c\/p\u003e \u003cp\u003eChapter 12. Histologic Markers of Neurotoxicity (Nonfluorenscence).\u003c\/p\u003e \u003cp\u003eChapter 13. Common Histologic Artifacts in Nervous System Tissues.\u003c\/p\u003e \u003cp\u003eChapter 14. High-Definition Microscopic Analysis of the Nervous System.\u003c\/p\u003e \u003cp\u003eChapter 15. Stereological Solutions for Common Quantitative Endpoints in Neurotoxicity.\u003c\/p\u003e \u003cp\u003eChapter 16. Anatomy and Processing of Peripheral Nerve Tissues.\u003c\/p\u003e \u003cp\u003eChapter 17. Pathology Methods in Non-clinical Neurotoxicity Studies: Evaluation of Muscle.\u003c\/p\u003e \u003cp\u003eChapter 18\u003ci\u003e. In Vivo\u003c\/i\u003e Imaging Applications for the Nervous System in Animal Models.\u003c\/p\u003e \u003cp\u003eChapter 19. Cerebrospinal Fluid Analysis in Toxicologic Neuropathology.\u003c\/p\u003e \u003cp\u003eChapter 20. Molecular Techniques in Toxicologic Neuropathology.\u003c\/p\u003e \u003cp\u003ePart 3. Toxicologic Neuropathology: Current Practices.\u003c\/p\u003e \u003cp\u003eChapter 21. Evaluation of the Adult Nervous System in Preclinical Studies.\u003c\/p\u003e \u003cp\u003eChapter 22. Pathology Methods in Non-clinical Neurotoxicity Studies: Developing Central Nervous System.\u003c\/p\u003e \u003cp\u003eChapter 23. Neuropathology Analysis of the Peripheral Nervous System.\u003c\/p\u003e \u003cp\u003eChapter 24. Toxicologic Pathology of the Retina and Optic Nerve.\u003c\/p\u003e \u003cp\u003eChapter 25. Toxicologic Neurpathology of the Ear.\u003c\/p\u003e \u003cp\u003eChapter 26. Neurpathology of the Olfactory System.\u003c\/p\u003e \u003cp\u003ePart 4. Applied Toxicologic Neuropathology.\u003c\/p\u003e \u003cp\u003eChapter 27. Spinal Delivery and Assessment of Drug Safety.\u003c\/p\u003e \u003cp\u003eChapter 28. Diagnostic Neuropathology.\u003c\/p\u003e \u003cp\u003eChapter 29. Toxicologic Neuropathology in Medical Practice.\u003c\/p\u003e \u003cp\u003eChapter 30. Toxiciologic Neuropathology in Veterinary Practice.\u003c\/p\u003e \u003cp\u003eChapter 31. Regulatory Considerations in Toxicologic Neuropathology.\u003c\/p\u003e \u003cp\u003eChapter 32. The Neuropathology Report and the Neuropathology Peer Review Report.\u003c\/p\u003e \u003cp\u003eChapter 33. Preparation of Personnel for Neuropathology Assessment.\u003c\/p\u003e \u003cp\u003eChapter 34. Regulatory Guide to the Histopathologic Assessment of Neurotoxicity Studies.\u003c\/p\u003e \u003cp\u003eChapter 35. Toxicologic Neuropathology: The Next Two Decades.\u003c\/p\u003e \u003cp\u003eAppendices.\u003c\/p\u003e \u003cp\u003eReady References of Neurobiology Knowledge.\u003c\/p\u003e \u003cp\u003eAppendix 1. Neural Cell Markers of Potential Utility for Toxicologic Neuropathology Applications.\u003c\/p\u003e \u003cp\u003eAppendix 2. Neuroanatomic Atlases for Toxicologic Neuropathology Studies.\u003c\/p\u003e \u003cp\u003eAppendix 3. Text-Based Basic Neurobiology References for Toxicologic Neuropathologists.\u003c\/p\u003e \u003cp\u003eAppendix 4. Web-Based Neurobiology References for Toxicologic Neuropathogists.\u003c\/p\u003e \u003cp\u003eAppendix 5. Toxicologic Neuropathology References for Nervous System Targets.\u003c\/p\u003e \u003cp\u003eAppendix 6. Comparative and Correlative Neurobiological Parameters Related to Neuropathology Assessment.\u003c\/p\u003e \u003cp\u003eAppendix 7. Comparison of Central Nervous System Proportions Between Humans and Rats.\u003c\/p\u003e \u003cp\u003eAppendix 8. Chemical Composition of Central Nervous System Tissues and Fluids.\u003c\/p\u003e  \u003cp\u003e“This is a comprehensive text that includes a wealth of information on a very wide range of subjects. It will, of course, appeal to veterinary pathologists and neurotoxicologists, but it will also serve as a very good guide for diagnostic neuropathologists or histopathologists entering the world of toxicological or pharmacological research.”  (\u003ci\u003eThe Bulletin of The Royal College of Pathologists\u003c\/i\u003e, 1 October 2012)\u003c\/p\u003e \u003cp\u003e“Overall this is a long awaited, extremely useful book which should be on the shelf of all pathologists, toxicologists and students working in the field of neurotoxicology or pathology. “  (\u003ci\u003eBritish Toxicology Society Newsletter\u003c\/i\u003e, 1 June 2012)\u003c\/p\u003e \u003cp\u003e“This exceptional, high quality book will greatly benefit its intended audience.”  (\u003ci\u003eDoody\u003c\/i\u003e\u003ci\u003e’\u003c\/i\u003e\u003ci\u003es\u003c\/i\u003e, 4 May 2012)\u003c\/p\u003e  \u003cb\u003eBRAD BOLON, DVM, MS, PhD, Diplomate ACVP, Diplomate ABT, Fellow ATS, Fellow IATP\u003c\/b\u003e, has spent over twenty years as a practitioner and teacher of toxicologic neuropathology. He is the founder of GEMpath, Inc., an experimental pathology consultancy specializing in drug discovery research.  \u003cp\u003e\u003cb\u003eMARK T. BUTT, DVM, Diplomate ACVP,\u003c\/b\u003e is the founder of Tox Path Specialists, LLC, a company that provides neuropathology and histology support to pharmaceutical and biotechnology firms developing novel therapies that target nervous system diseases. He has over twenty years' experience providing neuropathology support and has evaluated over four hundred studies supporting regulatory submissions for neuroactive compounds.\u003c\/p\u003e  \u003cp\u003eGrasp the fundamentals behind neuropathology\u003c\/p\u003e \u003cp\u003eFundamental Neuropathology for Pathologists and Toxicologists: Principles and Techniques provides an introduction to the discipline and techniques of neuropathology. Aimed not only at pathologists and toxicologists, but more broadly at comparative neurotoxicologists, environmental scientists, students, and other experts working in the scientific and medical worlds as well, the book is an invaluable guide to understanding diseases of the central and peripheral nervous systems.\u003c\/p\u003e \u003cp\u003eWith a focus on the practical applications of assessing chemical toxicity, the book addresses both the fundamentals of neuropathology, and provides detailed coverage of current practices in anatomic, biochemical, clinical, and molecular analyses. In addition, it examines the practical aspects of neuropathology, such as study design data interpretation, regulatory considerations, and tips for preparing reports.\u003c\/p\u003e \u003cp\u003eDescribing the intricacies of the nervous system and the standard testing procedures that help toxicologists make neuropathological evaluations, Fundamental Neuropathology for Pathologists and Toxicologists is essential reading for anyone interested in understanding the chemical, environmental, biological, medical, and regulatory details important for analyzing toxicant-induced neurodiseases.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989255176421,"sku":"NP9780470227336","price":183.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470227336.jpg?v=1761783398","url":"https:\/\/k12savings.com\/es\/products\/fundamental-neuropathology-for-pathologists-and-toxicologists-isbn-9780470227336","provider":"K12savings","version":"1.0","type":"link"}