{"product_id":"fluorine-in-medicinal-chemistry-and-chemical-biology-isbn-9781405167208","title":"Fluorine in Medicinal Chemistry and Chemical Biology","description":"The extraordinary potential of fluorine-containing molecules in medicinal chemistry and chemical biology has been recognized by researchers outside of the traditional fluorine chemistry field, and thus a new wave of fluorine chemistry is rapidly expanding its biomedical frontiers. With several of the best selling drugs in the world crucially containing fluorine atoms, the incorporation of fluorine to drug leads has become an essential practice in biomedical research, especially for drug design and discovery as well as development.  \u003cp\u003eFocusing on the unique and significant roles that fluorine plays in medicinal chemistry and chemical biology, this book reviews recent advances and future prospects in this rapidly developing field. Topics covered include:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eDiscovery and development of fluorine containing drugs and drug candidates.\u003c\/li\u003e \u003cli\u003eNew and efficient synthetic methods for medicinal chemistry and the optimisation of fluorine-containing drug candidates.\u003c\/li\u003e \u003cli\u003eStructural and chemical biology of fluorinated amino acids and peptides.\u003c\/li\u003e \u003cli\u003eFluorine labels as probes in metabolic study, protein engineering and clinical diagnosis.\u003c\/li\u003e \u003cli\u003eApplications of 19F NMR spectroscopy in biomedical research.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eAn appendix presents an invaluable index of all fluorine-containing drugs that have been approved by the US Food and Drug Administration, including information on structure and pharmaceutical action.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eFluorine in Medicinal Chemistry and Chemical Biology\u003c\/i\u003e will serve as an excellent reference source for graduate students as well as academic and industrial researchers who want to take advantage of fluorine in biomedical research.\u003c\/p\u003e \u003cb\u003e\u003ci\u003eIntroduction\u003c\/i\u003e\u003c\/b\u003e  \u003cp\u003e\u003c\/p\u003e Chapter 1 “Unique Properties of Fluorine and Their Relevance to Medicinal Chemistry and Chemical Biology” by Takashi Yamazaki, Takeo Taguchi and Iwao Ojima  \u003cp\u003e\u003c\/p\u003e \u003cb\u003e\u003ci\u003eMedicinal Chemistry\u003c\/i\u003e\u003c\/b\u003e  \u003cp\u003e\u003c\/p\u003e Chapter 2 “Fluorinated Prostanoids: Development of Tafluprost, a New Anti-glaucoma Agent” by Yasushi Matsumura  \u003cp\u003e\u003c\/p\u003e Chapter 3 “Fluorinated conformationally restricted glutamate analogs for CNS drug discovery and development” by Atsuro Nakazato  \u003cp\u003e\u003c\/p\u003e Chapter 4 “Fluorinated Inhibitors of Matrix Metalloproteinases” by Roberta Sinisi, Monika Jagodzinska, Gabriele Candiani, Florent Huguenot, Monica Sani, Alessandro Volonterio, Raffaella Maffezzoni and Matteo Zanda  \u003cp\u003e\u003c\/p\u003e Chapter 5 “Fluoro-Taxoid Anticancer Agents” by Antonella Pepe, Larisa Kuznetsova, Liang Sun and Iwao Ojima  \u003cp\u003e\u003c\/p\u003e Chapter 6 “Antimalarial Fluoroartemisinins: Increased Metabolic and Chemical Stability”by Jean-Pierre Bégué, Danièle Bonnet-Delpon  \u003cp\u003e\u003c\/p\u003e Chapter 7 “Synthesis and Biological Activity of Fluorinated Nucleosides” by Tokumi Maruyama, Masahiro Ikejiri, Kunisuke Izawa and Tomoyuki Onishi  \u003cp\u003e\u003c\/p\u003e   \u003cp\u003e\u003c\/p\u003e \u003cb\u003e\u003ci\u003eSynthetic methods for medicinal chemistry and chemical biology\u003c\/i\u003e\u003c\/b\u003e  \u003cp\u003e\u003c\/p\u003e Chapter 8 “Synthesis of \u003ci\u003egem\u003c\/i\u003e-Difluoromethylenated Nucleosides \u003ci\u003evia\u003c\/i\u003e \u003ci\u003egem\u003c\/i\u003e-Difluoromethylene-Containing Building Blocks” by Wei-Dong Meng and Feng-Ling Qing  \u003cp\u003e\u003c\/p\u003e Chapter 9 “Recent Advances in the Syntheses of Fluorinated Amino Acids” by Kenji Uneyama  \u003cp\u003e\u003c\/p\u003e Chapter 10 “Fluorinated Moieties for Replacement of Amide and Peptide Bonds” by Takeo Taguchi and Hikaru Yanai  \u003cp\u003e\u003c\/p\u003e Chapter 11 “Perfluorinated Heteroaromatic Systems as Scaffolds for Drug Discovery” by David Armstrong, Matthew W. Cartwright, Emma L. Parks, Graham Pattison, Graham Sandford, Rachel Slater, John A. Christopher, David D. Miller, Paul W. Smith and Antonio Vong  \u003cp\u003e\u003c\/p\u003e Chapter 12 “\u003ci\u003egem\u003c\/i\u003e-Difluorocyclopropanes as key building blocks for novel biologically active molecules” by Toshiyuki Itoh  \u003cp\u003e\u003c\/p\u003e Chapter 13 “Fluorous Mixture Synthesis (FMS) of Drug-Like Molecules and Enantiomers, Stereoisomers, and Analogs of Natural Products” by Wei Zhang  \u003cp\u003e\u003c\/p\u003e Chapter 14 “Fluorine-18 Radiopharmaceuticals” by Michael R. Kilbourn and Xia Shao  \u003cp\u003e\u003c\/p\u003e \u003cb\u003e\u003ci\u003e\u003cbr\u003e \u003c\/i\u003e\u003c\/b\u003e  \u003cp\u003e\u003c\/p\u003e \u003cb\u003e\u003ci\u003eApplications of fluorinated amino acids and peptides to chemical biology and pharmacology\u003c\/i\u003e\u003c\/b\u003e  \u003cp\u003e\u003c\/p\u003e Chapter 15 “Application of Artificial Model Systems to Study the Interactions of Fluorinated Amino Acids within the Native Environment of Coiled Coil Proteins” by Mario Salwiczek, Toni Vagt and Beate Koksch  \u003cp\u003e\u003c\/p\u003e Chapter 16 “Fluorinated Amino Acids and Biomolecules in Protein Design and Chemical Biology” by He Meng, Ginevra A. Clark\u003csup\u003e,\u003c\/sup\u003e and \u003cst1:place w:st=\"on\"\u003eKrishna\u003c\/st1:place\u003e Kumar  \u003cp\u003e\u003c\/p\u003e Chapter 17 “Effects of Fluorination on the Bioorganic Properties of Methionine” by John F. Honek  \u003cp\u003e\u003c\/p\u003e Chapter 18 “Structure analysis of membrane-active peptides using \u003csup\u003e19\u003c\/sup\u003eF-labeled amino acids and solid state NMR” by Parvesh Wadhwani and Erik Strandberg  \u003cp\u003e\u003c\/p\u003e Chapter 19 “Metabolism of Fluorine-containing Drugs using \u003ci\u003ein vivo\u003c\/i\u003e Magnetic Resonance Spectroscopy” by Erika Schneider  \u003cp\u003e\u003c\/p\u003e   \u003cp\u003e\u003c\/p\u003e \u003cb\u003e\u003ci\u003eAppendix\u003c\/i\u003e\u003c\/b\u003e  \u003cp\u003e\u003c\/p\u003e “FDA-Approved Active Pharmaceutical Ingredients Containing Fluorine” by Elizabeth Pollina-Cormier, Manisha Das, and Iwao Ojima     Professor Iwao Ojima is Distinguished Professor in the Department of Chemistry, and Director of the Institute of Chemical Biology \u0026amp; Drug Discovery, at the State University of New York at Stony Brook. He has published over 340 papers and reviews, more than 140 patents and patent applications, and edited 5 books, including \u003ci\u003eBiomedical Frontiers of Fluorine Chemistry\u003c\/i\u003e, published in the ACS Symposium Series in 1996.  The extraordinary potential of fluorine-containing biologically relevant molecules in biology, medicinal chemistry, and medical applications has been recognized by researchers who are not in the traditional fluorine chemistry field, and thus a new wave of fluorine chemistry is expanding its biomedical frontiers. This book contains comprehensive reviews on cutting-edge developments and future prospects of fluorine in bioorganic and medicinal chemistry. It is essential for researchers who want to take advantage of the use of fluorine in biomedical research, from rational drug design, theory and synthesis to the use of fluorine labels as probes in metabolic study, protein engineering, and clinical diagnosis.","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47989223981285,"sku":"NP9781405167208","price":292.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781405167208.jpg?v=1761783272","url":"https:\/\/k12savings.com\/es\/products\/fluorine-in-medicinal-chemistry-and-chemical-biology-isbn-9781405167208","provider":"K12savings","version":"1.0","type":"link"}