{"product_id":"flow-cytometry-in-drug-discovery-and-development-isbn-9780470433560","title":"Flow Cytometry in Drug Discovery and Development","description":"This book covers the unique application of flow cytometry in drug discovery and development. The first section includes two introductory chapters, one on flow cytometry and one on biomarkers, as well as a chapter on recent advances in flow cytometry. The second section focuses on the unique challenges and added benefits associated with the use of flow cytometry in the drug development process. The third section contains a single chapter presenting an in depth discussion of validation considerations and regulatory compliance issues associated with drug development. \u003cp\u003ePreface xi\u003c\/p\u003e \u003cp\u003eForeword xiii\u003c\/p\u003e \u003cp\u003eAcknowledgments xv\u003c\/p\u003e \u003cp\u003eContributors xvii\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart I Introduction 1\u003cbr\u003e \u003c\/b\u003e\u003ci\u003ePhilip Marder and Virginia Litwin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1 Introduction to Flow Cytometry 3\u003cbr\u003e \u003ci\u003eElizabeth Raveche, Fatima Abbasi, Yao Yuan, Erica Salerno, Siddha Kasar, and Gerald E. Marti\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Recent Advances in Flow Cytometry: Platforms, Tools, and Challenges for Data Analysis 23\u003cbr\u003e \u003ci\u003ePaul J. Smith, Roy Edward, and Rachel J. Errington\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Introduction to Biomarkers 55\u003cbr\u003e \u003ci\u003eOle Vesterqvist and Manjula P. Reddy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II Flow Cytometry In The Drug Development Process 69\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eVirginia Litwin and Philip Marder\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 HTS Flow Cytometry, Small-Molecule Discovery, and the NIH Molecular Libraries Initiative 71\u003cbr\u003e \u003ci\u003eLarry A. Sklar and Bruce S. Edwards\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 A Multiparameter Approach to Cell Cycle Analysis as a Standard Tool in Oncology Drug Discovery 99\u003cbr\u003e \u003ci\u003eCarmen Raventos-Suarez and Byron H. Long\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Flow Cytometry in Preclinical Toxicology\/Safety Assessment 123\u003cbr\u003e \u003ci\u003eDavid McFarland and Kristi R. Harkins\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Use of Flow Cytometry to Study Drug Target Inhibition in Laboratory Animals and in Early-Phase Clinical Trials 151\u003cbr\u003e \u003ci\u003eDavid W. Hedley\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 CD4 T Cell Assessments in Evaluation of HIV Therapeutics 169\u003cbr\u003e \u003ci\u003eThomas N. Denny, Raul Louzao, John Wong, and Brooke Walker\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Monitoring the Cellular Components of the Immune System During Clinical Trials: A Translational Medicine Approach 189\u003cbr\u003e \u003ci\u003eVirginia Litwin and James Andahazy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Immunogenicity Testing Using Flow Cytometry 205\u003cbr\u003e \u003ci\u003eDenise M. O.Hara and Valerie Theobald\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Pharmacokinetics by Flow Cytometry: Recommendations for Development and Validation of Flow Cytometric Method for Pharmacokinetic Studies 225\u003cbr\u003e \u003ci\u003eYuanxin Xu and Susan M. Richards\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III Validation And Regulatory Compliance 241\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eVirginia Litwin and Philip Marder\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Regulatory Compliance and Method Validation 243\u003cbr\u003e \u003ci\u003eCarla G. Hill, Dianna Y. Wu, John Ferbas, Virginia Litwin, and Manjula P. Reddy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Instrument Validation for Regulated Studies 267\u003cbr\u003e \u003ci\u003eJohn Ferbas and Michelle J. Schroeder\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart IV Future Directions 279\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eVirginia Litwin and Philip Marder\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Probability State Modeling: A New Paradigm for Cytometric Analysis 281\u003cbr\u003e \u003ci\u003eC. Bruce Bagwell\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Phospho Flow Cytometry: Single-Cell Signaling Networks in Next-Generation Drug Discovery and Patient Stratification 303\u003cbr\u003e \u003ci\u003ePeter O. Krutzik, Sean C. Bendall, Matthew B. Hale, Jonathan M. Irish, and Garry P. Nolan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 335\u003c\/p\u003e  \u003cp\u003e\"Flow Cytometry in Drug Discovery and Development is a monograph which comprehensively addresses the technical aspects of flow cytometry applied to drug development.  Readers will learn how the unique benefits of this powerful analytical technique can be realized in the drug development process.\"  (\u003ci\u003eAnalytical and Bioanalytical Chemistry\u003c\/i\u003e, 29 July 2012)\u003c\/p\u003e \"This book covers the unique application of flow cytometry in drug discovery and development.\" (Smart Grid, 15 February 2011)  \u003cb\u003eVirginia Litwin\u003c\/b\u003e is a Principal Scientist at Covance Central Laboratory Services. After numerous years in the pharmaceutical\/biotechnology industry, she has become a leader in the application and validation of flow cytometric methods in drug discovery and development. She founded the Flow Cytometry Subcommittee of the Ligand Binding Assay Bioanalytical Focus Group within the American Association of Pharmaceutical Scientists (AAPS). She is an active contributor to the International Clinical Cytometry Society (ICCS) and the International Society for Analytical Cytology (ISAC). She received her bachelor's from the University of California and her doctorate from the University of Iowa.  \u003cp\u003e\u003cb\u003ePhilip Marder\u003c\/b\u003e was internationally distinguished for his leadership in the application of flow cytometry in early drug discovery and development. He was a key contributor to the scientific community as an active member of ISAC and AAPS. After receiving both his bachelor's and master's degrees from The Ohio State University, he had a distinguished thirty year career at Eli Lilly and Company.\u003c\/p\u003e  Overview of Flow Cytometry in Drug Discovery and Development  \u003cp\u003eIn this book, the unique application of flow cytometry in pharmaceutical discovery and development is presented. A basic explanation of the technology precedes a comprehensive review of specific examples of how the technology is utilized in drug development.\u003c\/p\u003e \u003cp\u003eReaders of this book will learn how flow cytometry's use of multiparametric, high-speed measurements and manipulations of single cells adds valuable information and efficiencies for the discovery and development of new, better, and more affordable pharmaceuticals. It discusses validation and regulatory compliance issues as well as the use of cytometry in monitoring clinical diseases and evaluating therapies.\u003c\/p\u003e \u003cp\u003eDivided into four parts, the book:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003eIncludes two introductory chapters, one on flow cytometry and one on biomarkers, as well as a chapter on recent advances in flow cytometry\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eFocuses on the unique challenges and added benefits associated with the use of flow cytometry in the drug development process\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003ePresents an in-depth discussion of validation considerations and regulatory compliance issues associated with drug development\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eEnds with two chapters addressing important future directions in the field of flow cytometry\u003c\/p\u003e \u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eWritten by thought-leaders from academia and industry as well as flow cytometry users from the pharmaceutical sector, this comprehensive and straightforward text helps pharmaceutical researchers understand the potential of flow cytometry and, in turn, allows flow cytometrists to understand the needs of the pharmaceutical industry.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989222277349,"sku":"NP9780470433560","price":155.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470433560.jpg?v=1761783267","url":"https:\/\/k12savings.com\/es\/products\/flow-cytometry-in-drug-discovery-and-development-isbn-9780470433560","provider":"K12savings","version":"1.0","type":"link"}