{"product_id":"essentials-of-medical-genomics-isbn-9780470140192","title":"Essentials of Medical Genomics","description":"\u003cul\u003e \u003cli\u003eSix new chapters on vital topics of interest such as multilocus SNP genotyping (SNP chips), RNAi, ChIP-chip, and genomic tiling arrays\u003c\/li\u003e \u003cli\u003eNew edition responds to reviewers' and users' desire for greater coverage—now the most useful handbook on the market!\u003c\/li\u003e \u003cli\u003ePractical, concise summary of everything about genomics and emerging technologies a busy physician or medical student should know\u003c\/li\u003e \u003cli\u003eCovers concepts and techniques that are in use in medicine now, as well as those on the cutting-edge of science relevant to medicine, from bioinformatics to DNA diagnostics and proteomics\u003c\/li\u003e \u003cli\u003e\n\u003cb\u003eNEW:\u003c\/b\u003e Includes chapter-end exercises, enhancing the utility of the new edition as a textbook\u003c\/li\u003e \u003cli\u003e\n\u003cb\u003eNEW:\u003c\/b\u003e PowerPoint slides of images available at instructor website\u003c\/li\u003e \u003c\/ul\u003e  Preface.  \u003cp\u003e\u003cb\u003e1\u003c\/b\u003e \u003cb\u003eIntroduction to Molecular Genetics.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe Principles of Inheritance.\u003c\/p\u003e \u003cp\u003eGenes Are Made of DNA.\u003c\/p\u003e \u003cp\u003eDNA Structure.\u003c\/p\u003e \u003cp\u003eThe Central Dogma.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2\u003c\/b\u003e \u003cb\u003eMolecular Biology Technology.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eCut, Copy, and Paste.\u003c\/p\u003e \u003cp\u003eRestriction Enzymes.\u003c\/p\u003e \u003cp\u003eDNA Cloning Is Copying.\u003c\/p\u003e \u003cp\u003ePCR Is Cloning without the Bacteria.\u003c\/p\u003e \u003cp\u003eDNA Sequencing.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3\u003c\/b\u003e \u003cb\u003eGenome Databases.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eGenome Sequencing.\u003c\/p\u003e \u003cp\u003eEntrez.\u003c\/p\u003e \u003cp\u003eBLAST.\u003c\/p\u003e \u003cp\u003eGenome Annotation.\u003c\/p\u003e \u003cp\u003eGenome Browser.\u003c\/p\u003e \u003cp\u003eHuman Genetic Diseases.\u003c\/p\u003e \u003cp\u003eA System for Naming Genes.\u003c\/p\u003e \u003cp\u003eModel Organisms (Comparative Genomics).\u003c\/p\u003e \u003cp\u003eSequencing Other Genomes.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4\u003c\/b\u003e \u003cb\u003eBioinformatics Tools.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003ePatterns and Tools.\u003c\/p\u003e \u003cp\u003eSequence Comparison.\u003c\/p\u003e \u003cp\u003eMultiple Alignment.\u003c\/p\u003e \u003cp\u003ePattern Finding.\u003c\/p\u003e \u003cp\u003ePhylogenetics.\u003c\/p\u003e \u003cp\u003eBiotechnology Exercise.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5\u003c\/b\u003e \u003cb\u003eHuman Genetic Variation.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMutation.\u003c\/p\u003e \u003cp\u003eSingle-Nucleotide Polymorphisms.\u003c\/p\u003e \u003cp\u003eLinkage.\u003c\/p\u003e \u003cp\u003eMultigene Diseases.\u003c\/p\u003e \u003cp\u003eGenetic Testing.\u003c\/p\u003e \u003cp\u003eSNP Chips.\u003c\/p\u003e \u003cp\u003eThe HapMap Project.\u003c\/p\u003e \u003cp\u003eResearch Uses of SNP Markers.\u003c\/p\u003e \u003cp\u003eEthnicity and Genome Diversity.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6\u003c\/b\u003e \u003cb\u003eGenetic Testing for the Practitioner\u003c\/b\u003e \u003ci\u003e(Harry Ostrer).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eClinical Applications of Genetic Testing.\u003c\/p\u003e \u003cp\u003eMethods of Genetic Testing.\u003c\/p\u003e \u003cp\u003eAdequacy of Genetic Testing.\u003c\/p\u003e \u003cp\u003eInformed Consent.\u003c\/p\u003e \u003cp\u003eGenetic Counseling.\u003c\/p\u003e \u003cp\u003eClinical Vignettes.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7\u003c\/b\u003e \u003cb\u003eGene Therapy\u003c\/b\u003e \u003ci\u003e(John G. Hay).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eHistorical Perspective.\u003c\/p\u003e \u003cp\u003eStrategies of Gene Therapy.\u003c\/p\u003e \u003cp\u003eDNA Elements for Gene Expression.\u003c\/p\u003e \u003cp\u003eGene Delivery Systems.\u003c\/p\u003e \u003cp\u003eTargeting Gene Delivery.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003eFormative Years and Initial Clinical Approaches.\u003c\/p\u003e \u003cp\u003eThe Problems.\u003c\/p\u003e \u003cp\u003eThe Future.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8\u003c\/b\u003e \u003cb\u003eMicroarrays.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSpotting versus Synthesis on the Chip.\u003c\/p\u003e \u003cp\u003eOther Types of Arrays.\u003c\/p\u003e \u003cp\u003eDifferential Gene Expression.\u003c\/p\u003e \u003cp\u003eError and Reliability.\u003c\/p\u003e \u003cp\u003eEvolutionary Perspectives.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9\u003c\/b\u003e \u003cb\u003eAnalysis of Microarray Data.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eExperimental Design.\u003c\/p\u003e \u003cp\u003eData Analysis Workflow.\u003c\/p\u003e \u003cp\u003eFunctional Analysis.\u003c\/p\u003e \u003cp\u003eValidation.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10\u003c\/b\u003e \u003cb\u003ePharmacogenomics and Toxicogenomics.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003ePharmacogenomics.\u003c\/p\u003e \u003cp\u003eEnvironmental Chemicals.\u003c\/p\u003e \u003cp\u003eToxicogenomics for Drug Development.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11\u003c\/b\u003e \u003cb\u003eClinical Research Informatics.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eClinical Databases.\u003c\/p\u003e \u003cp\u003eClinical Trials Management.\u003c\/p\u003e \u003cp\u003eData Standards and Ontologies.\u003c\/p\u003e \u003cp\u003eTissue Banks.\u003c\/p\u003e \u003cp\u003eApplication to Medical Practice.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12\u003c\/b\u003e \u003cb\u003eRNA Interference and MicroRNAs.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAntisense RNA.\u003c\/p\u003e \u003cp\u003eRNA Interference.\u003c\/p\u003e \u003cp\u003eRibozymes.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13\u003c\/b\u003e \u003cb\u003eAlternative Splicing.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eExon Arrays.\u003c\/p\u003e \u003cp\u003eMedical Applications of Alternative Splicing.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14\u003c\/b\u003e \u003cb\u003eGenome Tiling Chips.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eGenome Chips.\u003c\/p\u003e \u003cp\u003eResequencing Chips.\u003c\/p\u003e \u003cp\u003eWhole-Genome Transcription Profilig.\u003c\/p\u003e \u003cp\u003eChIP-chip.\u003c\/p\u003e \u003cp\u003eArrayCGH.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15\u003c\/b\u003e \u003cb\u003eCancer Genomics.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eUnderstanding Cancer Genomics.\u003c\/p\u003e \u003cp\u003eCopy Number Mutations.\u003c\/p\u003e \u003cp\u003eGene Expression Signatures.\u003c\/p\u003e \u003cp\u003eCancer Genome Atlas.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16\u003c\/b\u003e \u003cb\u003eProteomics.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eProtein Modifications.\u003c\/p\u003e \u003cp\u003eQuantitative Approaches.\u003c\/p\u003e \u003cp\u003eBiomarkers.\u003c\/p\u003e \u003cp\u003eProtein Databases.\u003c\/p\u003e \u003cp\u003eProtein–Protein Interactions.\u003c\/p\u003e \u003cp\u003eDNA-Binding Proteins.\u003c\/p\u003e \u003cp\u003eStructural Proteomics.\u003c\/p\u003e \u003cp\u003eDrug Targets.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17\u003c\/b\u003e \u003cb\u003eConsumer Genomics and Genealogy.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eGenealogy.\u003c\/p\u003e \u003cp\u003eNutrigenomics.\u003c\/p\u003e \u003cp\u003ePrivacy Concerns.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18\u003c\/b\u003e \u003cb\u003eThe Ethics of Medical Genomics.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eEugenics.\u003c\/p\u003e \u003cp\u003eHuman Genome Diversity Project and Population Genetics.\u003c\/p\u003e \u003cp\u003eGenetic Discrimination.\u003c\/p\u003e \u003cp\u003eImpact on Physicians and Researchers.\u003c\/p\u003e \u003cp\u003eClinical Research.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003eAppendix: Genetic Testing: Scientific Background for Policymakers (Amanda K. Sarata).\u003c\/p\u003e \u003cp\u003eGlossary.\u003c\/p\u003e \u003cp\u003eIndex.\u003c\/p\u003e \u003cp\u003eSTUART M. BROWN, PhD, is on the faculty of the New York University School of Medicine, where he is Associate Professor and Director of the Bioinfor-matics Core Facility and Director of the graduate Bioinformatics course.\u003c\/p\u003e   \u003cp\u003eAn up-to-date edition of the groundbreaking classic\u003c\/p\u003e \u003cp\u003eMedical genomics is rapidly moving into mainstream medicine, with new and emerging technologies such as molecular genetic diagnostic tests and gene therapy having an unprecedented impact in clinical practice. Consequently, there is an urgent need for physicians and medical students to understand these developments and their evolving roles in the post-genomics era. This book fills that important need with a practical, comprehensive introduction to genomics with a focus on its impact on medical research and practice.\u003c\/p\u003e \u003cp\u003eThis valuable new edition has been thoroughly and meticulously updated and expanded to include the most exciting and up-to-the-minute topics in biomedical research, including all-new chapters on multilocus SNP genotyping (SNP chips), RNAi, ChIP-chip, and genomic tiling arrays. It also includes thoroughly revised coverage of topics from the previous edition, including molecular biology, biotechnology, genome databases, bioinformatics tools, human genetic variation, genetic testing, gene therapy, microarray and related gene expression technology, analysis of microarray data, pharmacogenomics and toxico-genomics, clinical research informatics, alternative splicing, cancer genomics, proteomics, consumer genomics, and genetic data privacy and ethics.\u003c\/p\u003e \u003cp\u003eCovering concepts and techniques that are currently in use, as well as those on the cutting-edge of science, Essentials of Medical Genomics, Second Edition gives physicians and medical students everything they need to know about genomics and emerging technologies. Now 50% more comprehensive than the previous edition, and complemented with useful exercises and an appendix, this Second Edition is truly the most useful handbook available.\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47989161459941,"sku":"NP9780470140192","price":136.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470140192.jpg?v=1761783043","url":"https:\/\/k12savings.com\/es\/products\/essentials-of-medical-genomics-isbn-9780470140192","provider":"K12savings","version":"1.0","type":"link"}