{"product_id":"essential-developmental-biology-isbn-9781119512851","title":"Essential Developmental Biology","description":"\u003cb\u003eESSENTIAL DEVELOPMENTAL BIOLOGY\u003c\/b\u003e \u003cp\u003e\u003cb\u003eDiscover the foundations of developmental biology with this up to date and focused resource from two leading experts\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003eThe newly revised Fourth Edition of \u003ci\u003eEssential Developmental Biology\u003c\/i\u003e delivers the fundamentals of the developmental biology of animals. Designed as a core text for undergraduate students in their first to fourth years, as well as graduate students in their first year, the book is suited to both biologically based and medically oriented courses. The distinguished authors presume no prior knowledge of development, animal structure, or histology. \u003c\/p\u003e\u003cp\u003eThe new edition incorporates modern single cell transcriptome sequencing and CRISPR\/Cas9, as well as other methods for targeted genetic manipulation. The existing material has also been reorganized to provide for easier reading and learning for students. The book avoids discussions of history and experimental priority and emphasizes instead the modern advances in developmental biology. The authors have kept the text short and focused on the areas truly central to developmental biology. Readers will benefit from the inclusion of such topics as: \u003c\/p\u003e\u003cli\u003eA thorough discussion of the groundwork of developmental biology, including developmental genetics, cell signaling and commitment, and cell and molecular biology techniques\u003c\/li\u003e \u003cli\u003eAn exploration of major model organisms, including Xenopus, the zebrafish, the chick, the mouse, the human, Drosophila, and Caenorhabditis elegans\u003c\/li\u003e \u003cli\u003eA treatment of organogenesis, including postnatal development, and the development of the nervous system, mesodermal organs, endodermal organs, and imaginal discs in drosophila\u003c\/li\u003e \u003cli\u003eA final section on growth, stem cell biology, evolution, and regeneration\u003c\/li\u003e \u003cp\u003ePerfect for undergraduate students, especially those preparing to enter teaching or graduate studies in developmental biology, \u003ci\u003eEssential Developmental Biology\u003c\/i\u003e will also earn a place in the libraries of those in the pharmaceutical industry expected to be able to evaluate assays based on developmental systems.Essential Developmental Biology ist eine umfassende und reich illustrierte Einführung in sämtliche Aspekte der Entwicklungsbiologie. Die 3. Auflage dieses beliebten und zugänglichen Lehrbuchs wurde erweitert und aktualisiert.\u003cbr\u003e \u003cbr\u003e Die begleitende Website bietet darüber hinaus Lehr- und Lernmaterialien für Studenten und Dozenten, animierte Entwicklungsprozesse, eine Fotogalerie ausgewählter Modellorganismen und sämtliche Abbildungen usw. der Printversion zum Herunterladen.\u003cbr\u003e \u003cbr\u003e Dieses evidenzbasierte Lehrbuch liefert durchgängig Belege für zentrale Schlussfolgerungen und ist ein Muss sowohl für Einführungs- als auch Aufbaukurse der Entwicklungsbiologie.\u003cbr\u003e \u003c\/p\u003e\u003cp\u003ePreface, ix\u003c\/p\u003e \u003cp\u003eAbout the companion website, xi\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection 1: Groundwork, 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 The excitement of developmental biology, 3\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eWhere the subject came from, 3\u003c\/p\u003e \u003cp\u003eImpact of developmental biology, 4\u003c\/p\u003e \u003cp\u003eFuture impact, 5\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 How development works, 7\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eUltrashort summary, 7\u003c\/p\u003e \u003cp\u003eGametogenesis, 10\u003c\/p\u003e \u003cp\u003eEarly development, 13\u003c\/p\u003e \u003cp\u003eGrowth and death, 19\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Approaches to development: developmental genetics, 25\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eDevelopmental mutants, 25\u003c\/p\u003e \u003cp\u003eSex chromosomes, 27\u003c\/p\u003e \u003cp\u003eMaternal and zygotic, 27\u003c\/p\u003e \u003cp\u003eGenetic pathways, 28\u003c\/p\u003e \u003cp\u003eGenetic mosaics, 30\u003c\/p\u003e \u003cp\u003eScreening for mutants, 31\u003c\/p\u003e \u003cp\u003eCloning of genes, 32\u003c\/p\u003e \u003cp\u003eGain-and loss-of-function experiments, 32\u003c\/p\u003e \u003cp\u003eTransgenesis, 32\u003c\/p\u003e \u003cp\u003eOther gain-of- function techniques, 34\u003c\/p\u003e \u003cp\u003eTargeted mutagenesis, 34\u003c\/p\u003e \u003cp\u003eOther loss-of- function systems, 35\u003c\/p\u003e \u003cp\u003eGene duplication, 36\u003c\/p\u003e \u003cp\u003eLimitations of developmental genetics, 37\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Approaches to development: experimental embryology and its molecular basis, 39\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eNormal development, 39\u003c\/p\u003e \u003cp\u003eDevelopmental commitment, 42\u003c\/p\u003e \u003cp\u003eCriteria for proof, 48\u003c\/p\u003e \u003cp\u003eTranscription factors, 48\u003c\/p\u003e \u003cp\u003eTranscription factor families, 50\u003c\/p\u003e \u003cp\u003eOther controls of gene activity, 51\u003c\/p\u003e \u003cp\u003eSignaling systems, 51\u003c\/p\u003e \u003cp\u003eGenetic regulatory networks, 57\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Approaches to development: cell and molecular biology techniques, 61\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMicroscopy, 61\u003c\/p\u003e \u003cp\u003eOptical techniques, 61\u003c\/p\u003e \u003cp\u003eConfocal, multi-photon, and light sheet microscopes, 63\u003c\/p\u003e \u003cp\u003eImage capture, 63\u003c\/p\u003e \u003cp\u003eAnatomical and histological methods, 64\u003c\/p\u003e \u003cp\u003eMicroinjection, 66\u003c\/p\u003e \u003cp\u003eStudy of gene expression by molecular biology methods, 67\u003c\/p\u003e \u003cp\u003eStudy of gene expression by in situ methods, 72\u003c\/p\u003e \u003cp\u003eReporter genes, 75\u003c\/p\u003e \u003cp\u003eCell-labeling methods, 76\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Cells into tissues, 81\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eCells in embryos, 81\u003c\/p\u003e \u003cp\u003eCytoskeleton, 82\u003c\/p\u003e \u003cp\u003eSmall GTP-binding proteins, 84\u003c\/p\u003e \u003cp\u003eExtracellular matrix, 84\u003c\/p\u003e \u003cp\u003eCell movement, 85\u003c\/p\u003e \u003cp\u003eEpithelial organization, 86\u003c\/p\u003e \u003cp\u003eMorphogenetic processes, 88\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection 2: Major model organisms, 97\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Major model organisms, 99\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe big six, 99\u003c\/p\u003e \u003cp\u003eAccess and micromanipulation, 101\u003c\/p\u003e \u003cp\u003eGenetics and genomes, 101\u003c\/p\u003e \u003cp\u003eRelevance and tempo, 102\u003c\/p\u003e \u003cp\u003eOther organisms, 102\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Xenopus, 107\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eOogenesis, maturation, and fertilization, 108\u003c\/p\u003e \u003cp\u003eNormal development, 109\u003c\/p\u003e \u003cp\u003eFate maps, 114\u003c\/p\u003e \u003cp\u003eExperimental methods, 115\u003c\/p\u003e \u003cp\u003eProcesses of regional specification, 119\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 The zebrafish, 135\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eNormal development, 135\u003c\/p\u003e \u003cp\u003eFate map, 140\u003c\/p\u003e \u003cp\u003eGenetics, 141\u003c\/p\u003e \u003cp\u003eReverse genetic methods, 144\u003c\/p\u003e \u003cp\u003eEmbryological techniques, 145\u003c\/p\u003e \u003cp\u003eRegional specification, 145\u003c\/p\u003e \u003cp\u003eOther roles of the zebrafish, 150\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 The chick, 153\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eNormal development, 154\u003c\/p\u003e \u003cp\u003eFate map, 158\u003c\/p\u003e \u003cp\u003eRegional specification of the early embryo, 159\u003c\/p\u003e \u003cp\u003eDescription of organogenesis in the chick, 164\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 The mouse, 173\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMammalian fertilization, 173\u003c\/p\u003e \u003cp\u003eNormal development of the mouse, 177\u003c\/p\u003e \u003cp\u003eFate map, 184\u003c\/p\u003e \u003cp\u003eRegional specification in the mouse embryo, 185\u003c\/p\u003e \u003cp\u003eTransgenic mice, 190\u003c\/p\u003e \u003cp\u003eEmbryonic stem cells, 192\u003c\/p\u003e \u003cp\u003eKnockouts and knock-ins, 192\u003c\/p\u003e \u003cp\u003eNuclear transplantation and imprinting, 196\u003c\/p\u003e \u003cp\u003eX-inactivation, 196\u003c\/p\u003e \u003cp\u003eTeratocarcinoma, 198\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Human early development, 203\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eHuman reproduction, 203\u003c\/p\u003e \u003cp\u003ePreimplantation development, 205\u003c\/p\u003e \u003cp\u003eHuman embryonic stem cells, 207\u003c\/p\u003e \u003cp\u003eHuman postimplantation development, 208\u003c\/p\u003e \u003cp\u003ePostimplantation diagnosis: chorionic villus sampling and amniocentesis, 211\u003c\/p\u003e \u003cp\u003eEthics of human development, 211\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Drosophila, 217\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eInsects, 217\u003c\/p\u003e \u003cp\u003eNormal development, 219\u003c\/p\u003e \u003cp\u003eFate map, 222\u003c\/p\u003e \u003cp\u003ePole plasm, 224\u003c\/p\u003e \u003cp\u003eDrosophila developmental genetics, 224\u003c\/p\u003e \u003cp\u003eThe developmental program, 227\u003c\/p\u003e \u003cp\u003eThe dorsoventral pattern, 228\u003c\/p\u003e \u003cp\u003eThe anteroposterior system, 232\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Caenorhabditis elegans, 247\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAdult anatomy, 248\u003c\/p\u003e \u003cp\u003eEmbryonic development, 249\u003c\/p\u003e \u003cp\u003eRegional specification in the embryo, 251\u003c\/p\u003e \u003cp\u003eAnalysis of postembryonic development, 259\u003c\/p\u003e \u003cp\u003eThe germ line, 262\u003c\/p\u003e \u003cp\u003eProgrammed cell death, 264\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection 3: Organogenesis, 269\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Techniques for studying organogenesis and postnatal development, 271\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eGenetics, 271\u003c\/p\u003e \u003cp\u003eClonal analysis, 275\u003c\/p\u003e \u003cp\u003eTissue and organ culture, 278\u003c\/p\u003e \u003cp\u003eCell analysis and separation, 279\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 Development of the nervous system, 283\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eOverall structure and cell types, 283\u003c\/p\u003e \u003cp\u003eRegional specification, 286\u003c\/p\u003e \u003cp\u003eNeurogenesis and gliogenesis, 292\u003c\/p\u003e \u003cp\u003eThe neural crest, 299\u003c\/p\u003e \u003cp\u003eDevelopment of neuronal connectivity, 303\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 Development of mesodermal organs, 315\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSomitogenesis, 315\u003c\/p\u003e \u003cp\u003eMyogenesis, 322\u003c\/p\u003e \u003cp\u003eThe kidney, 323\u003c\/p\u003e \u003cp\u003eGerm cell and gonadal development, 326\u003c\/p\u003e \u003cp\u003eSex determination, 330\u003c\/p\u003e \u003cp\u003eLimb development, 330\u003c\/p\u003e \u003cp\u003eBlood and blood vessels, 340\u003c\/p\u003e \u003cp\u003eThe heart, 343\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18 Development of endodermal organs, 355\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eNormal development, 355\u003c\/p\u003e \u003cp\u003eOrganization of the gut tube, 356\u003c\/p\u003e \u003cp\u003eFate map of the endoderm, 359\u003c\/p\u003e \u003cp\u003eExperimental analysis of endoderm development, 359\u003c\/p\u003e \u003cp\u003eThe pancreas, 366\u003c\/p\u003e \u003cp\u003e\u003cb\u003e19 Drosophila imaginal discs, 373\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMetamorphosis, 373\u003c\/p\u003e \u003cp\u003eGenetic study of larval development, 374\u003c\/p\u003e \u003cp\u003eDisc development, 378\u003c\/p\u003e \u003cp\u003eCompartments and selector genes, 378\u003c\/p\u003e \u003cp\u003eRegional patterning of the wing disc, 381\u003c\/p\u003e \u003cp\u003eRegeneration and transdetermination, 384\u003c\/p\u003e \u003cp\u003eMorphogen gradients and polarity, 387\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection 4: Growth, evolution, regeneration, 391\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e20 Tissue organization and stem cells, 393\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eTypes of tissue, 393\u003c\/p\u003e \u003cp\u003eTissue renewal, 397\u003c\/p\u003e \u003cp\u003eStem cells, 401\u003c\/p\u003e \u003cp\u003eIntestinal epithelium, 403\u003c\/p\u003e \u003cp\u003eEpidermis, 408\u003c\/p\u003e \u003cp\u003eHair follicles, 410\u003c\/p\u003e \u003cp\u003eHematopoietic system, 415\u003c\/p\u003e \u003cp\u003eMesenchymal stem cells and “transdifferentiation”, 419\u003c\/p\u003e \u003cp\u003eSpermatogonia, 419\u003c\/p\u003e \u003cp\u003e\u003cb\u003e21 Growth, aging, and cancer, 425\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eGrowth: control of size and proportion, 425\u003c\/p\u003e \u003cp\u003eBiochemical pathways of growth control, 426\u003c\/p\u003e \u003cp\u003eGrowth control in insects, 429\u003c\/p\u003e \u003cp\u003eGrowth control in mammals, 431\u003c\/p\u003e \u003cp\u003eLiver regeneration, 433\u003c\/p\u003e \u003cp\u003eGrowth in stature, 434\u003c\/p\u003e \u003cp\u003eAging, 436\u003c\/p\u003e \u003cp\u003eCell autonomous processes, 437\u003c\/p\u003e \u003cp\u003eThe insulin pathway and aging, 438\u003c\/p\u003e \u003cp\u003eCaloric restriction, 438\u003c\/p\u003e \u003cp\u003eCancer, 440\u003c\/p\u003e \u003cp\u003eClassification of tumors and precursor lesions, 440\u003c\/p\u003e \u003cp\u003eMolecular biology of cancer, 442\u003c\/p\u003e \u003cp\u003eCancer stem cells, 443\u003c\/p\u003e \u003cp\u003eCancer progression, 444\u003c\/p\u003e \u003cp\u003eCancer therapy, 445\u003c\/p\u003e \u003cp\u003e\u003cb\u003e22 Pluripotent stem cells and their applications, 449\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eHuman embryonic stem cells, 449\u003c\/p\u003e \u003cp\u003eInduced pluripotent stem cells, 451\u003c\/p\u003e \u003cp\u003eSomatic cell nuclear transfer, 453\u003c\/p\u003e \u003cp\u003eDirect reprogramming, 454\u003c\/p\u003e \u003cp\u003eApplications of human pluripotent stem cells, 455\u003c\/p\u003e \u003cp\u003eCell transplantation therapy, 457\u003c\/p\u003e \u003cp\u003eCell transplantation therapies using pluripotent stem cells, 459\u003c\/p\u003e \u003cp\u003eTransplantation therapy for diabetes, 460\u003c\/p\u003e \u003cp\u003eRetinal pigment epithelium, 462\u003c\/p\u003e \u003cp\u003eSpinal repair, 463\u003c\/p\u003e \u003cp\u003eCardiomyocytes, 463\u003c\/p\u003e \u003cp\u003eParkinson’s disease, 463\u003c\/p\u003e \u003cp\u003eIntroduction of new therapies, 465\u003c\/p\u003e \u003cp\u003e\u003cb\u003e23 Evolution and development, 469\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMacroevolution, 470\u003c\/p\u003e \u003cp\u003eMolecular taxonomy, 471\u003c\/p\u003e \u003cp\u003ePhylogeny of animals, 472\u003c\/p\u003e \u003cp\u003eThe fossil record, 473\u003c\/p\u003e \u003cp\u003eThe primordial animal, 474\u003c\/p\u003e \u003cp\u003eBasal animals, 479\u003c\/p\u003e \u003cp\u003eWhat really happened in evolution?, 481\u003c\/p\u003e \u003cp\u003eSegmented body plans and Hox genes, 482\u003c\/p\u003e \u003cp\u003eInsect wings and legs, 483\u003c\/p\u003e \u003cp\u003eAtavisms, 483\u003c\/p\u003e \u003cp\u003eVertebrate limbs, 485\u003c\/p\u003e \u003cp\u003e\u003cb\u003e24 Regeneration of missing parts, 491\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eTypes of regeneration, 491\u003c\/p\u003e \u003cp\u003eDistribution of regenerative capacity, 491\u003c\/p\u003e \u003cp\u003ePlanarian regeneration, 492\u003c\/p\u003e \u003cp\u003eInsect limb regeneration, 497\u003c\/p\u003e \u003cp\u003eVertebrate limb regeneration, 499\u003c\/p\u003e \u003cp\u003eThe process of limb regeneration, 499\u003c\/p\u003e \u003cp\u003eThe source of cells for regeneration, 501\u003c\/p\u003e \u003cp\u003eRegeneration of regional pattern, 502\u003c\/p\u003e \u003cp\u003eRegeneration: ancestral or adaptive property?, 508\u003c\/p\u003e \u003cp\u003eGeneral properties of regeneration, 509\u003c\/p\u003e \u003cp\u003eGlossary, 513\u003c\/p\u003e \u003cp\u003eIndex, 527\u003c\/p\u003e \u003cp\u003e\u003cb\u003eProfessor Jonathan M.W. Slack \u003c\/b\u003eis an emeritus professor of the University of Bath, UK, where he was Head of the Department of Biology and Biochemistry; and the University of Minnesota, USA, where he was director of the Stem Cell Institute. He is a member of the European Molecular Biology Organization and a ??Fellow of the Academy of Medical Sciences. He has published numerous research papers on developmental biology as well as five other books, including \u003ci\u003eThe Science of Stem Cells\u003c\/i\u003e (Wiley-Blackwell 2018).\u003c\/p\u003e \u003cp\u003e\u003cb\u003eProfessor Leslie Dale \u003c\/b\u003eis Professor of Developmental Biology at University College London, UK, where he was Head of Teaching for the Department of Cell and Developmental Biology. He teaches developmental biology to both undergarduate and medical students. For his PhD he studied regeneration in Drosophila imaginal discs and subsequently the development of \u003ci\u003eXenopus\u003c\/i\u003e embryos.  \u003c\/p\u003e\u003cp\u003e\u003cb\u003eDiscover the foundations of developmental biology with this up to date and focused resource from two leading experts\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe newly revised Fourth Edition of \u003ci\u003eEssential Developmental Biology\u003c\/i\u003e delivers the fundamentals of the developmental biology of animals. Designed as a core text for undergraduate students in their first to fourth years, as well as graduate students in their first year, the book is suited to both biologically based and medically oriented courses. The distinguished authors presume no prior knowledge of development, animal structure, or histology. \u003c\/p\u003e\u003cp\u003eThe new edition incorporates modern single cell transcriptome sequencing and CRISPR\/Cas9, as well as other methods for targeted genetic manipulation. The existing material has also been reorganized to provide for easier reading and learning for students. The book avoids discussions of history and experimental priority and emphasizes instead the modern advances in developmental biology. The authors have kept the text short and focused on the areas truly central to developmental biology. Readers will benefit from the inclusion of such topics as: \u003c\/p\u003e\u003cli\u003eA thorough discussion of the groundwork of developmental biology, including developmental genetics, cell signaling and commitment, and cell and molecular biology techniques\u003c\/li\u003e \u003cli\u003eAn exploration of major model organisms, including Xenopus, the zebrafish, the chick, the mouse, the human, Drosophila, and Caenorhabditis elegans\u003c\/li\u003e \u003cli\u003eA treatment of organogenesis, including postnatal development, and the development of the nervous system, mesodermal organs, endodermal organs, and imaginal discs in drosophila\u003c\/li\u003e \u003cli\u003eA final section on growth, stem cell biology, evolution, and regeneration\u003c\/li\u003e \u003cp\u003ePerfect for undergraduate students, especially those preparing to enter teaching or graduate studies in developmental biology, \u003ci\u003eEssential Developmental Biology\u003c\/i\u003e will also earn a place in the libraries of those in the pharmaceutical industry expected to be able to evaluate assays based on developmental systems.\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47989155594469,"sku":"NP9781119512851","price":86.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781119512851.jpg?v=1761783022","url":"https:\/\/k12savings.com\/es\/products\/essential-developmental-biology-isbn-9781119512851","provider":"K12savings","version":"1.0","type":"link"}