{"product_id":"engineering-complex-phenotypes-in-industrial-strains-isbn-9780470610756","title":"Engineering Complex Phenotypes in Industrial Strains","description":"This book highlights current trends and developments in the area of engineering strains. The book details the current and future tools used in the production of bulk chemicals and biofuels from renewable biomass using green technologies. Complex phenotypes are traits in a microbe that requires multiple genetic changes to be modulated simultaneously in the microorganism’s DNA. Knowing what those genetic changes are for a given trait and how to make those changes in the most efficient way forms the motivation behind writing this book. This book explains the newer tools to develop and enable engineered strains at time scales much faster that the natural evolution process so that we can increase a cells' production of a certain substance, increase process productivity, and extend metabolic capability. This book provides a one stop platform of reference for practicing researchers in the field of industrial biotechnology. This book also explains that the commercial success of a process that uses microbial catalysts over platforms that use chemical catalysts and fossil fuels depends on the time it takes to engineer these microbes to perform the desired reaction under harsh manufacturing conditions and at rates that meets the criteria for economic feasibility.  \u003cp\u003eForeword vii\u003cbr\u003e \u003ci\u003eJohn Pierce\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003ePreface ix\u003c\/p\u003e \u003cp\u003eContributors xi\u003c\/p\u003e \u003cp\u003e1 Classical Strain Improvement 1\u003cbr\u003e \u003ci\u003eNathan Crook and Hal S. Alper\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Tracer-Based Analysis of Metabolic Flux Networks 35\u003cbr\u003e \u003ci\u003eMichael Dauner\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Integration of “Omics” Data with Genome-Scale Metabolic Models 77\u003cbr\u003e \u003ci\u003eStephen Van Dien, Priti Pharkya, and Robin Osterhout\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Strain Improvement via Evolutionary Engineering 111\u003cbr\u003e \u003ci\u003eByoungjin Kim, Jing Du, and Huimin Zhao\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Rapid Fermentation Process Development and Optimization 133\u003cbr\u003e \u003ci\u003eJun Sun and Lawrence Chew\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 The Clavulanic Acid Strain Improvement Program at DSM Anti-Infectives 169\u003cbr\u003e \u003ci\u003eBert Koekman and Marcus Hans\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Metabolic Engineering of Recombinant E. coli for the Production of 3-Hydroxypropionate 185\u003cbr\u003e \u003ci\u003eTanya Warnecke Lipscomb, Matthew L. Lipscomb, Ryan T. Gill, and Michael D. Lynch\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Complex System Engineering: A Case Study for an Unsequenced Microalga 201\u003cbr\u003e \u003ci\u003eMichael T. Guarnieri, Lieve M.L. Laurens, Eric P. Knoshaug, Yat-Chen Chou, Bryon S. Donohoe, and Philip T. Pienkos\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Meiotic Recombination-Based Genome Shuffling of Saccharomyces Cerevisiae and Schefferomyces Stiptis for Increased Inhibitor Tolerance to Lignocellulosic Substrate Toxicity 233\u003cbr\u003e \u003ci\u003eDominic Pinel and Vincent J.J. Martin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 251\u003c\/p\u003e  \u003cp\u003e“This book should be valuable to engineers, biochemists,  and students who seek to understand the science and practice of engineering biocatalysts for industrial applications.”  (\u003ci\u003eChemical Engineering Progress\u003c\/i\u003e\u003ci\u003e,\u003c\/i\u003e  1 January 2013)\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eRANJAN PATNAIK, PhD,\u003c\/b\u003e is a chemical engineer by profession with 17 years of practical experience in the field of industrial biotechnology that includes small biotech start-ups and large enterprises. His research interests are in the field of metabolic engineering, fermentation optimization, process integration and R\u0026amp;D technology management. He currently heads the biofuels research group at DuPont Knowledge Center (DKC), Hyderabad, India. Prior to his current role, he had a variety of responsibilities within the biochemical sciences \u0026amp; engineering division of CR\u0026amp;D, E. I. du Pont de Nemours and Company, Wilmington, DE, USA.\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eSets forth current strategies for engineering biocatalysts for the production of bulk chemicals and biofuels\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eWith coverage of biocatalysts ranging from \u003ci\u003eE. coli\u003c\/i\u003e and \u003ci\u003eStreptomyces\u003c\/i\u003e to yeast and microalgae, this book explains current trends and developments in engineering industrial strains for the production of bulk chemicals and biofuels from renewable biomass. The authors guide readers through tested and proven tools and methodologies, providing plenty of examples that enable readers to engineer the complex traits and phenotypes needed for particular biocatalysts and bioprocesses.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eEngineering Complex Phenotypes in Industrial Strains\u003c\/i\u003e features contributions from pioneers and leading international experts in the field. These authors offer insights into their thought processes as they initiate and develop a commercial biocatalyst engineering project. The first five chapters describe the current tools and technologies available for engineering and characterizing a complex phenotype in an industrial strain. The next four chapters feature detailed case studies:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eClavulanic acid strain improvement program\u003c\/li\u003e \u003cli\u003eMetabolic engineering of recombinant \u003ci\u003eE. coli\u003c\/i\u003e for the production of 3-hydroxypropionate\u003c\/li\u003e \u003cli\u003eComplex system engineering: case study for an unsequenced microalga\u003c\/li\u003e \u003cli\u003eMeiotic recombination-based genome shuffling of \u003ci\u003eSaccharomyces cerevisiae\u003c\/i\u003e and \u003ci\u003eScheffersomyces stipitis\u003c\/i\u003e for increased inhibitor tolerance to lignocellulosic substrate toxicity\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThese case studies underscore the many disciplines that underlie the engineering of biocatalysts as well as illustrate in detail the application of the tools and methodologies discussed in the first half of the book.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eEngineering Complex Phenotypes in Industrial Strains\u003c\/i\u003e is ideal for students and professionals in chemical engineering who need to understand the science and practice of engineering biocatalysts for a broad range of industrial applications.\u003c\/p\u003e","brand":"Wiley-AIChE","offers":[{"title":"Default Title","offer_id":47989136457957,"sku":"NP9780470610756","price":124.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470610756.jpg?v=1761782944","url":"https:\/\/k12savings.com\/es\/products\/engineering-complex-phenotypes-in-industrial-strains-isbn-9780470610756","provider":"K12savings","version":"1.0","type":"link"}