{"product_id":"encyclopedia-of-drug-metabolism-and-interactions-6-volume-set-isbn-9780470450154","title":"Encyclopedia of Drug Metabolism and Interactions, 6 Volume Set","description":"\u003cp\u003e\u003ci\u003e“This one-stop reference brings together information scattered throughout the literature, and it involved the efforts of 270 expert authors from 16 countries — a global endeavor accomplished under the leadership of editor Alexander Lyubimov.”\u003c\/i\u003e –Book News Inc., February 2013\u003c\/p\u003e \u003cp\u003e\u003cbr\u003e \u003cbr\u003e The \u003ci\u003eEncyclopedia of Drug Metabolism and Interactions\u003c\/i\u003e provides essential support during all phases of drug development, from drug design to drug action and interaction in patients.\u003c\/p\u003e \u003cp\u003eThis multivolume work covers both preclinical and clinical aspects of drug metabolism and interactions. It also provides a wealth of toxicological, regulatory, and marketing information, all written by leading international experts in the field. Using this reference you’ll discover:\u003c\/p\u003e \u003cp\u003e• Enzymes that can be inhibited or induced and their impact on drug toxicity and altered response in both animal and human models\u003cbr\u003e • Effect of genetic differences and non-genetic factors on drug metabolism\u003cbr\u003e • Balance among drug metabolism, its inactivation\/activation, and its potential toxicity\u003cbr\u003e • Examples demonstrating all aspects of drug metabolism and interactions in silico, in laboratory animals, and in humans\u003cbr\u003e • Methods and detailed protocols enabling you to perform seamless studies of metabolism and drug interactions\u003c\/p\u003e \u003cp\u003eThis reference is essential for researchers interested in all aspects of drug development, and chemists, pharmacologists, pharmaceutical specialists, toxicologists, molecular toxicologists, and clinicians, including practitioners and physicians.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eEnjoy the Online Advantage...\u003cbr\u003e \u003c\/b\u003eThe \u003ci\u003eEncyclopedia of Drug Metabolism and Interactions\u003c\/i\u003e is available online now. For further information visit \u003ca title=\"Encyclopedia of Drug Metabolism and Interactions\" href=\"http:\/\/onlinelibrary.wiley.com\/book\/10.1002\/9780470921920\" target=\"_blank\"\u003ewileyonlinelibrary.com\/ref\/lyubimov\u003c\/a\u003e\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\u003cb\u003eVOLUME I\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 1: Basics Overview of Drug Metabolism\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 1 Review of Drug Metabolism in Drug Discovery and Development\u003c\/p\u003e \u003cp\u003eChapter 2 Reactions and Models of Drug Metabolism\u003c\/p\u003e \u003cp\u003eChapter 3 Enzyme kinetics of drug metabolism reactions and drug-drug interactions\u003c\/p\u003e \u003cp\u003eChapter 4 Developmental changes in drug metabolizing enzymes\u003c\/p\u003e \u003cp\u003eChapter 5 Species differences in drug metabolizing enzymes\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II: Enzyme systems involved in drug metabolism and interactions in animals and humans\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 6 Structure and function of cytochrome P450 enzymes\u003c\/p\u003e \u003cp\u003eChapter 7 Mechanism of cytochrome P450 mediated reactions\u003c\/p\u003e \u003cp\u003eChapter 8 Transcriptional regulation of cytochrome P450 enzymes\u003c\/p\u003e \u003cp\u003eChapter 9 Cytochrome P450 polymorphisms\u003c\/p\u003e \u003cp\u003eChapter 10 Flavin monooxygenase\u003c\/p\u003e \u003cp\u003eChapter 11 Molybdenum containing enzymes\u003c\/p\u003e \u003cp\u003eChapter 12 Amine odidases and reductases\u003c\/p\u003e \u003cp\u003eChapter 13 Epoxide hydrolase\u003c\/p\u003e \u003cp\u003eChapter 14 Esterases and amidases\u003c\/p\u003e \u003cp\u003eChapter 15 UDP- glucuronosyltransferases\u003c\/p\u003e \u003cp\u003eChapter 16 Sulfotransferases\u003c\/p\u003e \u003cp\u003eChapter 17 Glutathione S- transferases\u003c\/p\u003e \u003cp\u003eChapter 18 Amino acid conjugation\u003c\/p\u003e \u003cp\u003e\u003cb\u003eVOLUME II\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III: General principals of ADME. Drug transporters and other mechanisms of transport\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 1 Introduction to ADME. Overview\u003c\/p\u003e \u003cp\u003eChapter 2 Anatomical and Physiological Parameters that Influence Gastrointestinal Absorption\u003c\/p\u003e \u003cp\u003eChapter 3 Absorption of drugs into the body\u003c\/p\u003e \u003cp\u003eChapter 4 General principles of drug distribution\u003c\/p\u003e \u003cp\u003eChapter 5 ABC drug transporters and their impact on drug disposition\/drug sensitivity and resistance\u003c\/p\u003e \u003cp\u003eChapter 6 SLC family transporters\u003c\/p\u003e \u003cp\u003eChapter 7 General principles of drug metabolism\u003c\/p\u003e \u003cp\u003eChapter 8 Systems where drug metabolism occurs\u003c\/p\u003e \u003cp\u003eChapter 9 Mass balance studies in animals and humans\u003c\/p\u003e \u003cp\u003eChapter 10 Bioavailability and bioequivalence\u003c\/p\u003e \u003cp\u003eChapter 11 Allometric scaling\u003c\/p\u003e \u003cp\u003eChapter 12 Effect of protein binding in ADME\u003c\/p\u003e \u003cp\u003eChapter 13 Excretion systems\u003c\/p\u003e \u003cp\u003eChapter 14 Pharmacokinetics (PK) and toxicokinetics (TK)\u003c\/p\u003e \u003cp\u003eChapter 15 Experimental design\/mathematical models and data analysis\/interpretation for PK \/TK studies\u003c\/p\u003e \u003cp\u003eChapter 16 Physiologically-Based Pharmacokinetic Modeling\u003c\/p\u003e \u003cp\u003eChapter 17 Pharmacodynamics\u003c\/p\u003e \u003cp\u003eChapter 18 Interrelationships between Pharmacokinetics \/ Pharmacodynamics and metabolism\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart IV: ADME of some specific groups of drugs and delivery systems\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 19 ADME of herbal and dietary constituents\u003c\/p\u003e \u003cp\u003eChapter 20 ADME of anticancer drugs\u003c\/p\u003e \u003cp\u003eChapter 21 ADME of cardiovascular drugs\u003c\/p\u003e \u003cp\u003eChapter 22 ADME of biological drugs\u003c\/p\u003e \u003cp\u003eChapter 23 ADME of natural toxins\u003c\/p\u003e \u003cp\u003eChapter 24 Metabolism and drug-drug interactions in pregnant mother\/placenta\/fetus\u003c\/p\u003e \u003cp\u003e\u003cb\u003eVOLUME III\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart V: Drug Design and development\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 1 Where and when does drug metabolism enter as a concern?\u003c\/p\u003e \u003cp\u003eChapter 2 Challenges in frontloading toxicity testing of anti- cancer drugs in drug discovery\u003c\/p\u003e \u003cp\u003eChapter 3 Role of ADME for selection of new drug candidates\u003c\/p\u003e \u003cp\u003eChapter 4 Efficient drug development. How to speed up the development process\u003c\/p\u003e \u003cp\u003eChapter 5 Metabolite profiling and identification\u003c\/p\u003e \u003cp\u003eChapter 6 Bioactivation and oxidative stress\u003c\/p\u003e \u003cp\u003eChapter 7 Metabolism in drug safety evaluation\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart VI: Methods and protocols for prediction and evaluation of drug metabolism and drug interaction studies\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 8 In silico models of drug metabolism and drug interactions\u003c\/p\u003e \u003cp\u003eChapter 9 Methods for determination of enzyme kinetics and metabolic rates\u003c\/p\u003e \u003cp\u003eChapter 10 Assays and microarrays for metabolic pathways\u003c\/p\u003e \u003cp\u003eChapter 11 Applications using Caco-2 cells and TC7 cells for drug metabolism studies\u003c\/p\u003e \u003cp\u003eChapter 12 In vitro liver systems to study induction\/inhibition. Prediction of in vivo metabolism and drug-drug interactions\u003c\/p\u003e \u003cp\u003eChapter 13 Assessing the Hepatic Disposition and Toxicity of Xenobiotics Using Primary Hepatocytes\u003c\/p\u003e \u003cp\u003eChapter 14 Monoclonal Antibody Based Analyses of Human Drug Metabolism and Multifuctional Cytochromes P450\u003c\/p\u003e \u003cp\u003eChapter 15 Validation of precision- cut slices as a tool to study induction of drug metabolism\u003c\/p\u003e \u003cp\u003eChapter 16 Practical aspects of high throughput solubility and dissolution assessment in preformulation\u003c\/p\u003e \u003cp\u003eChapter 17 Integrated Approaches to Blood Brain Barrier and its role for drug metabolism and interactions\u003c\/p\u003e \u003cp\u003eChapter 18 In vivo models (not genetically modified)\u003c\/p\u003e \u003cp\u003eChapter 19 Using mouse knockout and transgenic models to study metabolism\u003c\/p\u003e \u003cp\u003e\u003cb\u003eVOLUME IV\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart VII: Pharmacology and toxicology\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 1 Introduction. Overview. Role of metabolism in drug toxicity\u003c\/p\u003e \u003cp\u003eChapter 2 Bioactivation I: Phase I (P450)\u003c\/p\u003e \u003cp\u003eChapter 3 Bioactivation II: Phase I (non P450)\u003c\/p\u003e \u003cp\u003eChapter 4 Bioactivation III: Phase II\u003c\/p\u003e \u003cp\u003eChapter 5 Covalent Binding\u003c\/p\u003e \u003cp\u003eChapter 6 MIST\u003c\/p\u003e \u003cp\u003eChapter 7 Cell- based predictors for Toxicities of Metabolites\u003c\/p\u003e \u003cp\u003eChapter 8 Toxicogenomics\u003c\/p\u003e \u003cp\u003eChapter 9 Metabonomics\u003c\/p\u003e \u003cp\u003eChapter 10 Proteomics\u003c\/p\u003e \u003cp\u003eChapter 11 Stereoselectivity in drug metabolism\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART VIII: Influence of physiological conditions, diseases, drug- food interactions, age, sex, and other factors on drug metabolism and effect\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 12 Genetic influence on metabolism\u003c\/p\u003e \u003cp\u003eChapter 13 Drug- Drug interactions 1: Inhibition\u003c\/p\u003e \u003cp\u003eChapter 14 Drug- Drug Interactions 2: Induction\u003c\/p\u003e \u003cp\u003eChapter 15 Ontogeny and Metabolism\u003c\/p\u003e \u003cp\u003eChapter 16 Natural Modulators of Human Drug Metabolism: Dietary supplements and their Clinical Relevance (Food Effects on Toxicity and Pharmacology)\u003c\/p\u003e \u003cp\u003eChapter 17 Idiosyncratic drug interactions\u003c\/p\u003e \u003cp\u003eChapter 18 Influence of inflammatory stress on drug (or xenobiotic) hepatotoxicity\u003c\/p\u003e \u003cp\u003eChapter 19 Regulation of Drug-Metabolizingnzymes and Transporters in Infection, Inflammation, and Cancer\u003c\/p\u003e \u003cp\u003e\u003cb\u003eVOLUME V\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart IX: Bioanalytical methods of studying metabolism\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 1 Introduction. Importance of in vivo\/in vitro analytical results in drug development Walter\u003c\/p\u003e \u003cp\u003eChapter 2 General principles of mass spectrometry: LC-MS, LC-MS\/MS, and GC-MS\u003c\/p\u003e \u003cp\u003eChapter 3 Electrospray and Infusion nanospray ionization\u003c\/p\u003e \u003cp\u003eChapter 4 Emerging Atmospheric pressure ionization\u003c\/p\u003e \u003cp\u003eChapter 5 Matrix assisted laser desorption ionization (MALDI)\u003c\/p\u003e \u003cp\u003eChapter 6 Ion trap and quadrupole MS\u003c\/p\u003e \u003cp\u003eChapter 7 Hybrid LTQ- FTMS for Drug Metabolism Applications\u003c\/p\u003e \u003cp\u003eChapter 8 Mass Spectrometry Imaging (MSI)\u003c\/p\u003e \u003cp\u003eChapter 9 Ion Mobility Spectrometry and High Performance Tandem MS for metabolism studies and identification\u003c\/p\u003e \u003cp\u003eChapter 10 Inductively coupled plasma mass spectrometry (ICP MS) for element- containing drug metabolism analysis\u003c\/p\u003e \u003cp\u003eChapter 11 Online Electrochemical LC- MS Techniques for Profiling\u003c\/p\u003e \u003cp\u003eChapter 12 NMR\u003c\/p\u003e \u003cp\u003eChapter 13 Whole body autography and radioactive and non- radioactive isotope assays\u003c\/p\u003e \u003cp\u003eChapter 14 Ligand binding assays (immunoassays)\u003c\/p\u003e \u003cp\u003eChapter 16 Direct plasma analysis systems\u003c\/p\u003e \u003cp\u003eChapter 17 Analytical method development and validation in accordance to the regulatory guidelines\u003c\/p\u003e \u003cp\u003eChapter 18 Leveraging advances in HPLC to maximize DMPK data quality\u003c\/p\u003e \u003cp\u003eChapter 19 Methodologies to Increase Analytical Throughput\u003c\/p\u003e \u003cp\u003eChapter 20 Biomarkers to enable PK\/PD\u003c\/p\u003e \u003cp\u003eChapter 21 Bioanalytics for Human Microdosing\u003c\/p\u003e \u003cp\u003eChapter 22 Bioactivation and Reactive Metabolite Assays\u003c\/p\u003e \u003cp\u003eChapter 23 Plasma protein binding\u003c\/p\u003e \u003cp\u003e\u003cb\u003eVOLUME VI\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart X: Clinical aspects of drug metabolism and interactions\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 1 Overview and introduction. Role of drug metabolism and drug interactions in humans\u003c\/p\u003e \u003cp\u003eChapter 2 Human cytochrome P450 enzymes\u003c\/p\u003e \u003cp\u003eChapter 3 DDI Risk Assessment and Evaluation in Clinical Development: Interfacing Drug Metabolism and Clinical Pharmacology\u003c\/p\u003e \u003cp\u003eChapter 4 Current and future tools for predicting clinical drug interactions\u003c\/p\u003e \u003cp\u003eChapter 5 Predicting human biotransformation pathways\u003c\/p\u003e \u003cp\u003eChapter 6 Conjugation, transport, and elimination of drugs in humans\u003c\/p\u003e \u003cp\u003eChapter 7 Role and clinical consequences of human UDP- Glucuronosyltransferases\u003c\/p\u003e \u003cp\u003eChapter 8 Drug\/food and drug\/herb interactions\u003c\/p\u003e \u003cp\u003eChapter 9 Effects of disease on metabolism of drugs in humans\u003c\/p\u003e \u003cp\u003eChapter 10 Role of Phase I metabolism in drug activation and clinical treatment outcomes\u003c\/p\u003e \u003cp\u003eChapter 11 Role of metabolism in toxicity of drugs in humans\u003c\/p\u003e \u003cp\u003eChapter 12 Idiosyncratic drug reactions and the potential role of metabolism\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart XI Metabolism of specific drug groups and patient populations\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 13 Metabolism of psychotropic drugs\u003c\/p\u003e \u003cp\u003eChapter 14 Metabolic-based consequences of polytherapy with AED\u003c\/p\u003e \u003cp\u003eChapter 15 Oral chemotherapeutic agents: Understanding mechanisms of action and drug interactions\u003c\/p\u003e \u003cp\u003eChapter 16 Drug metabolism and interactions in pediatric patients\u003c\/p\u003e \u003cp\u003eChapter 17 Population- based pharmacokinetic modeling and simulation\u003c\/p\u003e \u003cp\u003eChapter 18 Clinical Pharmacology in drug labeling. The impact of drug metabolism and clinical pharmacology on recommended dose of drugs\u003c\/p\u003e  \u003cp\u003e“This one-stop reference brings together information scattered throughout the literature, and it involved the efforts of 270 expert authors from 16 countries — a global endeavor accomplished under the leadership of editor Alexander Lyubimov (pharmacology, The U. of Illinois, Chicago).”  (\u003ci\u003eBook News\u003c\/i\u003e, 1 February 2013)\u003c\/p\u003e \u003cp\u003e\"Summing Up: Recommended.  Graduate students through professionals\/practitioners.”   (\u003ci\u003eChoice\u003c\/i\u003e, 1 March 2013)\u003c\/p\u003e \u003cp\u003e\u003cb\u003eALEXANDER V. LYUBIMOV, MD, PhD, DABT,\u003c\/b\u003e is Director of the Toxicology Research Laboratory and Associate Professor of Pharmacology at the University of Illinois at Chicago. He has more than thirty years of experience in the fields of toxicology, bioanalytical chemistry, and drug efficacy. He has presented his research results at more than fifty national and international scientific conferences. In addition, he has published more than 140 scientific publications in peer-reviewed journals, books, and conference proceedings. Dr. Lyubimov has served as chair or president of several international conferences, including \"Frontiers of Pharmacology and Toxicology,\" which he also organized.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989129248997,"sku":"NP9780470450154","price":2206.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470450154.jpg?v=1761782914","url":"https:\/\/k12savings.com\/es\/products\/encyclopedia-of-drug-metabolism-and-interactions-6-volume-set-isbn-9780470450154","provider":"K12savings","version":"1.0","type":"link"}