{"product_id":"drug-transporters-isbn-9781119737551","title":"Drug Transporters","description":"\u003cb\u003eDRUG TRANSPORTERS\u003c\/b\u003e  \u003cp\u003e\u003cb\u003eDrug transporter fundamentals and relevant principles and techniques, featuring new and expanded chapters\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003e\u003ci\u003eDrug Transporters: Molecular Characterization and Role in Drug Disposition\u003c\/i\u003e provides in-depth analysis of the conceptual evolution and technical development for studying drug transporters. Contributions by an international panel of leading researchers address advances in transporters as drug targets, transporters in pharmacotherapy, the impact of transporters on drug efficacy and safety, the development of sophisticated model systems and sensitive assay methods, and more. Divided into two parts, the book first provides a thorough overview of relevant drug transporters before detailing the principles of drug transport and associated techniques. \u003c\/p\u003e\u003cp\u003eThe updated and expanded third edition includes new chapters on in vitro-in vivo scale-up of drug transport activities, the ontogeny of drug transporters, the application of physiologically-based pharmacokinetic and pharmacodynamic modeling, and the use of transporters as therapeutic targets for diseases. \u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eReflects the current state of the field and offers perspectives on future directions\u003c\/li\u003e \u003cli\u003eCovers basic knowledge, clinical outcomes, and emerging discoveries in transporter science\u003c\/li\u003e \u003cli\u003eProvides up-to-date information on drug transporter families, mechanisms, and clinical implications\u003c\/li\u003e \u003cli\u003eIncludes extensive references and numerous figures and tables throughout\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003eUnderstandable for novices while offering sufficient depth for more experienced researchers, \u003ci\u003eDrug Transporters: Molecular Characterization and Role in Drug Disposition, Third Edition\u003c\/i\u003e is an excellent textbook for pharmacological or physiological science courses in drug\/membrane transport, and an invaluable reference for academic or industrial scientists working in the transporter field and related areas of drug metabolism, pharmacokinetics, and pharmacodynamics. \u003c\/p\u003e\u003cp\u003eList of Contributors\u003c\/p\u003e \u003cp\u003ePreface\u003c\/p\u003e \u003cp\u003eCHAPTER 1.  Overview of Drug Transporter Families\u003cbr\u003e\u003ci\u003eGuofeng You and Marilyn E. Morris\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 2. Organic Cation and Zwitterion Transporters\u003cbr\u003e\u003ci\u003eMegan L. Koleske, Xiaomin Liang, Osatohanmwen Jessica Enogieru, Dina Buitrago, and KathleenM. Giacomini\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 3. Multidrug and Toxin Extrusion Proteins\u003cbr\u003e\u003ci\u003eLauren M. Aleksunes, Victoria Woo, and Melanie S. Joy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 4. Organic Anion Transporters (OATs)\u003cbr\u003e\u003ci\u003eJeffry C. Granados, Jingui Zhang, Guofeng You, Sanjay K. Nigam\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 5. Organic Anion Transporting Polypeptides OATP\u003cbr\u003e\u003ci\u003eRommel G. Tirona and Richard B. Kim\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 6. Mammalian Oligopeptide Transporters\u003cbr\u003e\u003ci\u003eStephen M. Carl,  Dea Herrera-Ruiz, Rajinder K. Bhardwaj, Olafur Gudmundsson, Stephanie Mowery, and Gregory T. Knipp.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 7. Monocarboxylic Acid Transporters\u003cbr\u003e\u003ci\u003eMarilyn E. Morris and Nisha V. Kwatra\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 8. The Nucleoside Transporters CNTs and ENTs\u003cbr\u003e\u003ci\u003eRaj Govindarajan, Antonio López Quiñones, and Joanne Wang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 9. Bile Acid Transporters\u003cbr\u003e\u003ci\u003eEbehiremen N. Ayewoh and  Peter W. Swaan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 10. The P-glycoprotein Multidrug Transporter\u003cbr\u003e\u003ci\u003eAndaleeb Sajid, Sabrina Lusvarghi and Suresh V. Ambudkar\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 11. Multidrug Resistance Proteins of the ABCC Subfamily\u003cbr\u003e\u003ci\u003eAnne T. Nies and Franziska Klein\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 12. ABCG2, the Breast Cancer Resistance Protein (BCRP)\u003cbr\u003e\u003ci\u003eRobert W. Robey, Sabrina Lusvarghi, Cindy H. Chau, Agnes Basseville, William D. Figg, Suresh V. Ambudkar, and Susan E. Bates\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 13. Drug Transport in the Liver\u003cbr\u003e\u003ci\u003eNoora Sjöstedt, Jeffry Adiwidjaja, William A. Murphy, and Kim L.R. Brouwer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 14. Drug Transport in the Brain\u003cbr\u003e\u003ci\u003eVishal Sangha, Erica I. Williams, Patrick T. Ronaldson, and Reina Bendayan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 15. Drug Transport in the Kidney\u003cbr\u003e\u003ci\u003eDouglas H. Sweet\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 16. Drug transporters in the human intestine\u003cbr\u003e\u003ci\u003eStefan Oswald\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 17. Drug Transport in the Placenta\u003cbr\u003e\u003ci\u003eQingcheng Mao, Vadivel Ganapathy, and Jashvant D. Unadkat\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 18. Polymorphisms of drug transporters and clinical relevance\u003cbr\u003e\u003ci\u003eTore B. Stage and Deanna L. Kroetz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 19. Ontogeny of Drug Transporters\u003cbr\u003e\u003ci\u003eMelanie A. Felmlee and Qing Zhang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 20.  Experimental Approaches for Studying Drug Transporters\u003cbr\u003e\u003ci\u003eYusuke Masuo, Azusa Futatsugi, and Yukio Kato\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 21. Transporters mediated drug disposition – Physiochemistry and in silico approaches\u003cbr\u003e\u003ci\u003eManthena V. S. Varma, Ayman El-Kattan, and Yurong Lai\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 22. In vitro-in vivo scale-up of drug transport activities\u003cbr\u003e\u003ci\u003eKazuya Maeda and Yuichi Sugiyama\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 23. Application of Physiologically Based Pharmacokinetic and Pharmacodynamic (PBPK\/PD) Modeling Comprising Transporters: Delineating the Role of Various Factors in Drug Disposition and Toxicity\u003cbr\u003e\u003ci\u003eMatthew D. Harwood, Amin Rostami-Hodjegan,  and Sibylle Neuhoff\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 24. Transporters as therapeutic targets in human diseases\u003cbr\u003e\u003ci\u003eRobert S. Jones and Eugene C. Chen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 25. Diet\/Nutrient Interactions with Drug Transporters\u003cbr\u003e\u003ci\u003eMarilyn E. Morris and Tianjing Ren\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex\u003c\/p\u003e \u003cp\u003e\u003cb\u003eGuofeng You, PhD, \u003c\/b\u003eDistinguished Professor of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, New Jersey, USA.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eMarilyn E. Morris, PhD,\u003c\/b\u003e SUNY Distinguished Professor and Chair, Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, USA.  \u003c\/p\u003e\u003cp\u003e\u003cb\u003eDrug transporter fundamentals and relevant principles and techniques, featuring new and expanded chapters\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDrug Transporters: Molecular Characterization and Role in Drug Disposition\u003c\/i\u003e provides in-depth analysis of the conceptual evolution and technical development for studying drug transporters. Contributions by an international panel of leading researchers address advances in transporters as drug targets, transporters in pharmacotherapy, the impact of transporters on drug efficacy and safety, the development of sophisticated model systems and sensitive assay methods, and more. Divided into two parts, the book first provides a thorough overview of relevant drug transporters before detailing the principles of drug transport and associated techniques. \u003c\/p\u003e\u003cp\u003eThe updated and expanded third edition includes new chapters on in vitro-in vivo scale-up of drug transport activities, the ontogeny of drug transporters, the application of physiologically-based pharmacokinetic and pharmacodynamic modeling, and the use of transporters as therapeutic targets for diseases. \u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eReflects the current state of the field and offers perspectives on future directions\u003c\/li\u003e \u003cli\u003eCovers basic knowledge, clinical outcomes, and emerging discoveries in transporter science\u003c\/li\u003e \u003cli\u003eProvides up-to-date information on drug transporter families, mechanisms, and clinical implications\u003c\/li\u003e \u003cli\u003eIncludes extensive references and numerous figures and tables throughout\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003eUnderstandable for novices while offering sufficient depth for more experienced researchers, \u003ci\u003eDrug Transporters: Molecular Characterization and Role in Drug Disposition, Third Edition\u003c\/i\u003e is an excellent textbook for pharmacological or physiological science courses in drug\/membrane transport, and an invaluable reference for academic or industrial scientists working in the transporter field and related areas of drug metabolism, pharmacokinetics, and pharmacodynamics.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989088846053,"sku":"NP9781119737551","price":269.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781119737551.jpg?v=1761782749","url":"https:\/\/k12savings.com\/es\/products\/drug-transporters-isbn-9781119737551","provider":"K12savings","version":"1.0","type":"link"}