{"product_id":"drug-resistance-in-epilepsy-isbn-9780470841464","title":"Drug Resistance in Epilepsy","description":"The object of this book is to gather together workers in the fields of epilepsy, those concerned with the basic science of resistance and the blood-brain barrier, and those with clinical experience of drug resistance in cancer, with a view to stimulating further work on drug resistance in epilepsy. Whilst resistance in cancer has been extensively studied, and trials of reversal of resistance have been undertaken, with some success, resistance in epilepsy has only just begun to be addressed. Chair's Introduction (V. Ling).\u003cbr\u003e \u003cbr\u003e The problem of the drug-resistant epilepsies (J. W. Sander).\u003cbr\u003e \u003cbr\u003e Drug resistance molecules: lessons from oncology (George L.Scheffer and Rik J. Scheper).\u003cbr\u003e \u003cbr\u003e Drug resistance in epilepsy: the role of the blood-brain barrier(N. Joan Abbott, et al.).\u003cbr\u003e \u003cbr\u003e P glycoprotein and the mechanism of multidrug resistance (A.Varadi, et al).\u003cbr\u003e \u003cbr\u003e Drug resistance caused by multidrug resistance-associated proteins(J. Wijnholds).\u003cbr\u003e \u003cbr\u003e Reversal of multidrug resistance: lessons from clinical oncology(S. E. Bates, et al.).\u003cbr\u003e \u003cbr\u003e Clinical development of P glycoprotein modulators in oncology (A.Oza).\u003cbr\u003e \u003cbr\u003e Gene expression profiling of epothilone A-resistant cells (P.Atadja, et al.).\u003cbr\u003e \u003cbr\u003e Imaging of P glycoprotein function in vivo with PET (N. H.Hendrikse and W. Vaalburg).\u003cbr\u003e \u003cbr\u003e Animal models of drug-resistant epilepsy (W. Loscher).\u003cbr\u003e \u003cbr\u003e Drug resistance in epilepsy: human epilepsy (S. M. Sisodiya, etal).\u003cbr\u003e \u003cbr\u003e Cellular mechanisms of pharmacoresistance in slices from epilepsysurgery (R. A. Deisz).\u003cbr\u003e \u003cbr\u003e Functional polymorphisms of the human multidrug resistance (MDR1)gene: correlation with P glycoprotein expression and activity invivo (U. Brinkmann).\u003cbr\u003e \u003cbr\u003e OC144-093, a novel P glycoprotein inhibitor for the enhancement ofanti-epileptic therapy (M. J. Newman, et al.).\u003cbr\u003e \u003cbr\u003e Closing remarks (V. Ling).\u003cbr\u003e \u003cbr\u003e Index of contributors.\u003cbr\u003e \u003cbr\u003e Subject Index.  The \u003cstrong\u003eNovartis Foundation\u003c\/strong\u003e is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.  Drug resistance in epilepsy is an important clinical problem. About 20% of patients diagnosed as having epilepsy fail to respond to prescribed antiepileptic drugs and continue to have seizures. But despite the size of the problem, remarkably little attention has been paid to the biological basis of refractory epilepsy. Recent work has shown that brain tissue from some patients with epilepsy shows increased expression of a protein that mediates drug resistance in cancer, P glycoprotein. But while resistance in cancer has been extensively studied, and trials of reversal of resistance have been undertaken with some success, resistance in epilepsy has only just begun to be addressed. This novel book brings together, for the first time, epilepsy researchers and oncologists, with a view to stimulating further work on drug resistance in epilepsy. Successfully bridging the two fields, the stimulating discussions contained in this book should be of great interest to those working on cancer resistance and refractory epilepsy alike.","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989088452837,"sku":"NP9780470841464","price":211.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470841464.jpg?v=1761782746","url":"https:\/\/k12savings.com\/es\/products\/drug-resistance-in-epilepsy-isbn-9780470841464","provider":"K12savings","version":"1.0","type":"link"}