{"product_id":"drug-discovery-for-the-treatment-of-addiction-isbn-9780470614167","title":"Drug Discovery for the Treatment of Addiction","description":"\u003cp\u003e\u003cbr\u003e With addiction a key target for drug discovery efforts, this book fills an important and timely need for medicinal chemists who need to understand complex neuroscience issues. The author illustrates medicinal chemistry's prominent role in treating addiction and covers specific drugs of abuse including narcotics, stimulants, depressants, nicotine, and marijuana.\u003c\/p\u003e \u003cp\u003e• Interprets complex neuro- biological and pharmacological information, like the drug-reward system, for medicinal chemists\u003cbr\u003e • Emphasizes neurotransmitters and neurochemical mechanisms of addictive drugs\u003cbr\u003e • Pulls together information on the many potential drug targets for treating addiction\u003cbr\u003e • Stresses unique medicinal chemistry problems when describing pharmacology testing methods and drug development\u003c\/p\u003e  \u003cp\u003ePreface xiii\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 What Is Drug Addiction? 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Definitions 2\u003c\/p\u003e \u003cp\u003e1.2 The Drugs of Abuse 4\u003c\/p\u003e \u003cp\u003e1.3 Schedule of Controlled Substances 5\u003c\/p\u003e \u003cp\u003e1.4 Some Facts From 2012 NSDUH Study 6\u003c\/p\u003e \u003cp\u003e1.5 The Addictive State 8\u003c\/p\u003e \u003cp\u003e1.6 Theories of Addiction 12\u003c\/p\u003e \u003cp\u003e1.7 Comorbidity 13\u003c\/p\u003e \u003cp\u003e1.8 Genetic Aspects of Addiction 13\u003c\/p\u003e \u003cp\u003e1.9 Approved Medications for the Treatment of Substance Abuse and Addiction 16\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Physiological Basis of Addiction—A Chemist's Interpretation 18\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 The Reward System 19\u003c\/p\u003e \u003cp\u003e2.2 Neuroanatomy of the Reward System 21\u003c\/p\u003e \u003cp\u003e2.3 Brief Review of the Central Nervous System and Addiction 22\u003c\/p\u003e \u003cp\u003e2.4 Neurotransmitters and Their Targets 25\u003c\/p\u003e \u003cp\u003e2.5 Neurocircuitry and Neurotransmitters in Addiction 32\u003c\/p\u003e \u003cp\u003e2.6 Location of Receptors 62\u003c\/p\u003e \u003cp\u003e2.7 An Example 64\u003c\/p\u003e \u003cp\u003e2.8 Use of Biological Markers 65\u003c\/p\u003e \u003cp\u003e2.9 Memories and Addiction 68\u003c\/p\u003e \u003cp\u003e2.10 Stress the HPA Axis and Addiction 72\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Behavioral Pharmacology and Addiction 76\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Animal Models of Addiction 76\u003c\/p\u003e \u003cp\u003e3.2 Self-Administration 80\u003c\/p\u003e \u003cp\u003e3.3 Conditioned Place Preference 85\u003c\/p\u003e \u003cp\u003e3.4 Tolerance 86\u003c\/p\u003e \u003cp\u003e3.5 Extinction\/Withdrawal 87\u003c\/p\u003e \u003cp\u003e3.6 Reinstatement (Animal Models of Relapse) 87\u003c\/p\u003e \u003cp\u003e3.7 Drug Discrimination 89\u003c\/p\u003e \u003cp\u003e3.8 Operant Sensation Seeking Model 92\u003c\/p\u003e \u003cp\u003e3.9 Use of Animal Behavioral Models 92\u003c\/p\u003e \u003cp\u003eAcknowledgments 93\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Medication Development for the Treatment of Drug Addiction 94\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Lead Discovery 95\u003c\/p\u003e \u003cp\u003e4.1.1 NIDA Addiction Treatment Discovery Program 96\u003c\/p\u003e \u003cp\u003e4.2 Pharmacological Assays 103\u003c\/p\u003e \u003cp\u003e4.3 Partial Agonist Approach 110\u003c\/p\u003e \u003cp\u003e4.4 Allosteric Modulators 110\u003c\/p\u003e \u003cp\u003e4.5 Functional Interactions Between Receptors 114\u003c\/p\u003e \u003cp\u003e4.6 Multi-Target Drugs 121\u003c\/p\u003e \u003cp\u003e4.7 Physicochemical Properties of CNS Drugs and Blood-Brain Barrier 124\u003c\/p\u003e \u003cp\u003e4.8 Brain Imaging Agents 131\u003c\/p\u003e \u003cp\u003e4.9 QT Prolongation 135\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Medication Development for Narcotic Addiction 137\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Pharmacology of Narcotic Addiction and Pain 138\u003c\/p\u003e \u003cp\u003e5.2 Prescription Drug Addiction 139\u003c\/p\u003e \u003cp\u003e5.3 Approved Medications 140\u003c\/p\u003e \u003cp\u003e5.4 Medication Development 151\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Medication Development for Stimulant Addiction 160\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Pharmacology of Cocaine Addiction 160\u003c\/p\u003e \u003cp\u003e6.2 Pharmacology of Methamphetamine Addiction 163\u003c\/p\u003e \u003cp\u003e6.3 Medication Development 166\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Medication Development for Depressant Addiction 213\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Pharmacology of Alcohol Addiction 213\u003c\/p\u003e \u003cp\u003e7.2 Approved Medications 214\u003c\/p\u003e \u003cp\u003e7.3 Medication Development 219\u003c\/p\u003e \u003cp\u003e7.4 Benzodiazepines 228\u003c\/p\u003e \u003cp\u003e7.5 Barbiturates 229\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Medication Development for Nicotine Addiction 230\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 Pharmacology of Nicotine Addiction 230\u003c\/p\u003e \u003cp\u003e8.2 Approved Medications 232\u003c\/p\u003e \u003cp\u003e8.3 Medication Development 237\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Medication Development for Marijuana Addiction 240\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Pharmacology of Marijuana Addiction 241\u003c\/p\u003e \u003cp\u003e9.2 CB1 Antagonist: Rimonabant 243\u003c\/p\u003e \u003cp\u003e9.3 Medication Development 244\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Designer Drugs 252\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 Cathinone Drugs 253\u003c\/p\u003e \u003cp\u003e10.2 MDMA—ECSTASY 256\u003c\/p\u003e \u003cp\u003e10.3 Cannabinoid Designer Drugs 257\u003c\/p\u003e \u003cp\u003eConclusion 259\u003c\/p\u003e \u003cp\u003eAppendix A Further Reading for Chemists Interested in a More Detailed Understanding of Addiction and the Central Nervous System 261\u003c\/p\u003e \u003cp\u003eAppendix B Public Databases and Sources of Information of Interest to Medicinal Chemistry Addiction Researchers 262\u003c\/p\u003e \u003cp\u003eAppendix C Glossary of Terms Used in Addiction Research 263\u003c\/p\u003e \u003cp\u003eAppendix D Glossary of Terms Used in Medicinal Chemistry 271\u003c\/p\u003e \u003cp\u003eReferences 290\u003c\/p\u003e \u003cp\u003eIndex 335\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eBrian S. Fulton\u003c\/b\u003e is a Visiting Lecturer in the Department of Chemistry and Chemical Biology at Northeastern University and has taught courses in organic chemistry, spectroscopy, and pharmaceutical sciences and has taught a one-semester course, Medicinal Chemistry of Psychiatric Drugs, at Harvard University Extension School. From 1987 – 2005, Dr. Fulton worked as an industrial organic chemist in the US and Europe. He obtained his B.S. in Chemistry at Missouri State University and his Ph.D. in Organic Chemistry at Iowa State University. He has written 17 peer-reviewed publications and given 8 presentations at scientific meetings.\u003c\/p\u003e \u003cp\u003eReveals the prominent role of medicinal chemistry in treating addiction\u003c\/p\u003e \u003cp\u003eWith addiction a key target for drug discovery efforts, this book fills an important and timely need for medicinal chemists who need to understand complex neuroscience issues. The author illustrates medicinal chemistry's prominent role in treating addiction and covers specific drugs of abuse including narcotics, stimulants, depressants, nicotine, and marijuana. Divided into two broad sections, the book first deals with general aspects of addiction, neuropharmacology, behavioural pharmacology, and drug development; and then delves more deeply into medication development. The book:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eInterprets complex neuro- biological and pharmacological information, like the drug-reward system, for medicinal chemists\u003c\/li\u003e \u003cli\u003eEmphasizes neurotransmitters and neurochemical mechanisms of addictive drugs\u003c\/li\u003e \u003cli\u003ePulls together information on the many potential drug targets for treating addiction\u003c\/li\u003e \u003cli\u003eStresses unique medicinal chemistry problems when describing pharmacology testing methods and drug development\u003c\/li\u003e \u003c\/ul\u003e A fascinating field of research with very real therapeutic outcomes, addiction deserves the attention of medicinal chemists. The author reduces this complex subject to where it is understandable to non-specialists and helps foster the kind of close working relationship between chemists and behavioural pharmacologists that is critical to effective drug development.","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989087699173,"sku":"NP9780470614167","price":133.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470614167.jpg?v=1761782745","url":"https:\/\/k12savings.com\/es\/products\/drug-discovery-for-the-treatment-of-addiction-isbn-9780470614167","provider":"K12savings","version":"1.0","type":"link"}