{"product_id":"developmental-neurotoxicology-research-isbn-9780470426722","title":"Developmental Neurotoxicology Research","description":"This book describes how systems biology, pharmacogenomic and behavioral approaches, as applied to neurodevelopmental toxicology, provide a structure to arrange information in a biological model. Authors review and discuss approaches that can be used as effective tools to dissect mechanisms underlying pharmacological and toxicological phenomena associated with the exposure to drugs or environmental toxicants during development. This book presents cross-cutting research tools and animal models, along with applications to the studies associated with potential anesthetic-induced developmental neurotoxicity; the developmental basis of adolescent or adult onset of disease; risk assessment of methyl mercury and its effects on neurodevelopment; challenges in the field to identify environmental factors of relevance to autism; and the strategy and progress of epilepsy research.  PREFACE.  \u003cp\u003eCONTRIBUTORS.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eI MODELS, APPROACHES, AND CHALLENGES IN NEUROTOXICITY RESEARCH DURING DEVELOPMENT\u003c\/b\u003e (\u003ci\u003eTucker A. Patterson\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e1 APPROACHES AND MODELS FOR EVALUATING THE TOXIC EFFECTS OF ANESTHETICS IN THE DEVELOPING NERVOUS SYSTEM (\u003ci\u003eWilliam Slikker, Jr., Xuan Zhang, Fang Liu, Merle G. Paule, and Cheng Wang\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e2 SYSTEMS BIOLOGY APPROACHES TO NEUROTOXICITY STUDIES DURING DEVELOPMENT (\u003ci\u003eTucker A. Patterson, Bradley J. Schnackenberg, William Slikker, Jr., and Cheng Wang\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e3 BEHAVIORAL APPROACHES FOR ASSESSING NERVOUS SYSTEM FUNCTION DURING DEVELOPMENT IN ANIMAL MODELS (\u003ci\u003eMerle G. Paule\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e4 APPLICATIONS OF UNBIASED STEREOLOGY TO NEURODEVELOPMENTAL TOXICOLOGY (\u003ci\u003ePeter R. Mouton\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003eII EFFECTS OF ANESTHETICS AND THEIR POTENTIAL NEUROTOXICITY DURING DEVELOPMENT\u003c\/b\u003e (\u003ci\u003eXuan Zhang and William Slikker, Jr.\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e5 NEUROTOXIC EFFECTS OF ANESTHETICS AND POTENTIAL PROTECTIVE AGENTS (\u003ci\u003eXuan Zhang, Tucker A. Patterson, Merle G. Paule, William Slikker, Jr., and Cheng Wang\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e6 PERINATAL RHESUS MONKEY MODELS AND ANESTHETIC-INDUCED NEURONAL CELL DEATH (\u003ci\u003eWilliam Slikker, Jr., Fang Liu, Xuan Zhang, Xiaoju Zou, Tucker A. Patterson, Merle G. Paule and Cheng Wang\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e7 EFFECTS OF GASEOUS ANESTHETIC COMBINATIONS DURING DEVELOPMENT (\u003ci\u003eVesna Jevtovic-Todorovic\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e8 PERINATAL ANESTHETIC ADMINISTRATION AND SHORT\/ LONG-TERM BEHAVIORAL DEFICITS (\u003ci\u003eVesna Jevtovic-Todorovic\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIII THE DEVELOPMENTAL BASIS OF ADOLESCENT OR ADULT DISEASE\u003c\/b\u003e (\u003ci\u003eJerrold J. Heindel\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e9 DEVELOPMENTAL LEAD EXPOSURE, EPIGENTICS AND LATE ONSET ALZHEIMER'S DISEASE (\u003ci\u003eNasser H. Zawia and Md. Riyaz Basha\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e10 DEVELOPMENTAL TRAJECTORIES OF AUTISM AND ENVIRONMENTAL EXPOSURES—WHAT WE KNOW AND WHERE WE NEED TO GO (\u003ci\u003eCindy P. Lawler and Alycia Halladay\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e11 ACTIONS OF MANGANESE ON PUBERTAL DEVELOPMENT (\u003ci\u003eW. Les Dees, Jill K. Hiney, and Vinod K. Srivastava\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e12 EXPOSURE OF THE DEVELOPING BRAIN TO POLYCHLORINATED BIPHENYLS INFLUENCES THE SUSCEPTIBILITY OF THE ADULT BRAIN TO STRESS (\u003ci\u003ePamela J. Lein, Kyung Ho Kim, Robert F. Berman, and Isaac N. Pessah\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e13 A NEURODEVELOPMENTAL ORIGIN FOR PAKINSON'S DISEASE: A LINK TO THE FETAL BASIS FOR ADULT DISEASE HYPOTHESIS (\u003ci\u003eD. Urbach-Ross and M. Thiruchelvam\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e14 GENETIC AND ENVIRONMENTAL FACTORS IN ATTENTION-DEFICIT HYPERACTIVITY DISORDER (\u003ci\u003eAngela Baker, Michele M. Taylor, and Jason R. Richardson\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIV RISK ASSESSMENT OF METHYL MERCURY AND ITS EFFECTS ON NEURODEVELOPMENT\u003c\/b\u003e (\u003ci\u003eMichael Aschner\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e15 FISH NUTRIENTS AND METHYLMERCURY: A VIEW FROM THE LABORATORY (\u003ci\u003eM. Christopher Newland\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e16 NEURODEVELOPMENTAL EFFECTS OF MATERNAL NUTRITION STATUS AND EXPOSURE TO METHYL MERCURY FROM EATING FISH DURING PREGNANCY: EVIDENCE FROM THE SEYCHELLES CHILD DEVELOPMENT STUDY (\u003ci\u003ePhilip W. Davidson, J.J. Strain, Gary J. Myers, Conrad F. Shamlaye, Sally Thurston, Maxine P. Bonham, Emeir M. Duffy, Julie M.W. Wallace, Gene Watson, and Thomas W. Clarkson\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e17 METHYLMERCURY NEUROTOXICOLOGY: FROM RARE POISONINGS TO SILENT PANDEMIC (\u003ci\u003ePhilippe Grandjean, Anna L. Choi, Pal Weihe, and Katsuyuki Murata\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e18 OXIDATIVE STRESS AND METHYLMERCURY-INDUCED NEUROTOXICITY (\u003ci\u003eMarcelo Farina, Joa ~o Batista Teixeira Rocha, and Michael Aschner\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e19 LEARNING DEFICITS AND DEPRESSION-LIKE BEHAVIORS ASSOCIATED WITH DEVELOPMENTAL METHYLMERCURY EXPOSURES (\u003ci\u003eNatalia Onishchenko and Sandra Ceccatelli\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e20 METHYLMERCURY EFFECTS ON NEURAL DEVELOPMENTAL SIGNALING PATHWAYS (\u003ci\u003eMatthew D. Rand\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003eV AUTISM SPECTRUM DISORDERS\u003c\/b\u003e (\u003ci\u003eIsaac N. Pessah\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e21 NEURODEVELOPMENTAL TOXICOLOGY AND AUTISM SPECTRUM DISORDERS (\u003ci\u003eRobert F. Berman, Claire M. Koenig, Michael R. Hunsaker, Isaac N. Pessah, and Janine M. Lasalle\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e22 REDOX IMBALANCE AND THE METABOLIC PATHOLOGY OF AUTISM (\u003ci\u003eRichard C. Deth, Mostafa Waly, Christina Muratore, and Nathaniel Hodgson\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e23 NEUROINFLAMMATION AND AUTISM (\u003ci\u003eG. Jean Harry\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e24AUTISM, PERIPHERAL IMMUNITY, AND POLYBROMINATED DIPHENYL ETHERS (\u003ci\u003ePaula Goines, Paul Ashwood, and Judy Van de Water\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e25 AN EMERGING GENE–ENVIRONMENT INTERACTION MODEL: AUTISM SPECTRUM DISORDER PHENOTYPES RESULTING FROM EXPOSURE TO ENVIRONMENTAL CONTAMINANTS DURING GESTATION (\u003ci\u003eDarryl B. Hood, Daniel Campbell, and Pat Levitt\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eSTRATEGIES AND PROGRESS IN EPILEPSY RESEARCH (\u003ci\u003eMerle G. Paule\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eVI STRATEGIES AND PROGRESS IN EPILEPSY RESEARCH (\u003ci\u003eMerle G. Paule\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eNEONATAL SEIZURES (\u003ci\u003eRenee A. Shellhaas\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e27 EXPERIMENTAL MODELS OF EPILEPTOGENESIS (\u003ci\u003eHana Kubova\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e28 EFFECT OF SEIZURES ON THE DEVELOPING BRAIN: LESSONS FROM THE LABORATORY (\u003ci\u003eShaun Hussain and Raman Sankar\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eINDEX.\u003c\/p\u003e  \u003cb\u003eCheng Wang\u003c\/b\u003e is Senior Neurobiologist in the Division of Neurotoxicology at the National Center for Toxicological Research, U.S. Food and DrugAdministration. He is the author of over fifty-five peer-reviewed publications and book chapters. Dr. Wang was awarded the Outstanding Performance Award at the Society of Toxicology 44th Annual Meeting and the 2007 FDA Scientific Achievement Award for Excellence in Laboratory Science.  \u003cp\u003e\u003cb\u003eWilliam Slikker, Jr.\u003c\/b\u003e, is the Director of the National Center for Toxicological Research, U.S. Food and Drug Administration. He has over 260 peer-reviewed scientific publications. Dr. Slikker has served as coeditor of several books and is an Associate Editor of the journals \u003ci\u003eNeuroToxicology\u003c\/i\u003e and \u003ci\u003eToxicological Sciences\u003c\/i\u003e.\u003c\/p\u003e  \u003cp\u003eHow preclinical research approaches can inform clinical interventions—and vice versa\u003c\/p\u003e \u003cp\u003eBecause of the complexity and temporal features of the developing brain, the developing nervous system may be more susceptible to neurotoxic insults. The study of neurodevelopmental toxicology has great potential for helping to advance the understanding of brain-related biological processes, including neuronal plasticity, neurodegeneration\/regeneration, toxicity, and effectiveness of many products. Developmental Neurotoxicology Research delineates how systems biology, pharmacogenomic, and behavioral approaches, as applied to neurodevelopmental toxicology, provide a structure to arrange information in a biological model.\u003c\/p\u003e \u003cp\u003eThe book presents:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003eCross-cutting research tools and animal models along with applications to the studies associated with potential anesthetic-induced developmental neurotoxicity\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eThe developmental basis of adolescent or adult onset of disease\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eRisk assessment of methyl mercury and its effects on neurodevelopment\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eChallenges in the field to identify environmental factors of relevance to autism\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eThe strategy and progress of epilepsy research\u003c\/p\u003e \u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eIncorporating new, post-genomic techniques, this book provides researchers with effective tools for dissecting the mechanisms underlying pharmacological and toxicological phenomena associated with the exposure to drugs or environmental toxicants during development.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989055095013,"sku":"NP9780470426722","price":203.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470426722.jpg?v=1761782608","url":"https:\/\/k12savings.com\/es\/products\/developmental-neurotoxicology-research-isbn-9780470426722","provider":"K12savings","version":"1.0","type":"link"}