{"product_id":"decoding-the-genomic-control-of-immune-reactions-isbn-9780470027554","title":"Decoding the Genomic Control of Immune Reactions","description":"This book explores existing and potential strategies for using the genome sequences of human, mouse, other vertebrates and human pathogens to solve key problems in the treatment of immunological diseases and chronic infections.  The assembled genome sequences now provide important opportunities for solving these problems, but a major bottleneck is the identification of key sequences and circuits controlling the relevant immune reactions. This will require innovative, interdisciplinary and collaborative strategies of a scale and complexity we are only now beginning to comprehend.  \u003cp\u003eSpecific problems addressed include the following:\u003c\/p\u003e \u003cul type=\"disc\"\u003e \u003cli\u003eWhat kinds of information are we lacking to understand how the genome sequence specifies the differentiation and response of immune system cells, and system behaviour such as immunological memory and tolerance?\u003c\/li\u003e \u003cli\u003eWhich genome sequences and cellular circuits cause or prevent pathological immune responses to foreign pathogens, allergens or self-tissues?\u003c\/li\u003e \u003cli\u003eWhich host and pathogen genome sequences and cellular circuits explain the failure of sterilizing immune responses to sophisticated human pathogens such as the agents of tuberculosis, malaria, metazoan parasites and chronic viruses?\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eContaining contributions from a range of leading experts in the field, this book provides an important new perspective for clinical immunologists and basic researchers alike.\u003c\/p\u003e  Introduction (\u003cb\u003eChris Goodnow)\u003c\/b\u003e.  \u003cp\u003eTranscriptional regulatory networks in macrophages. (\u003cb\u003eDavid A. Hume, Christine A. Wells\u003c\/b\u003e and \u003cb\u003eTimothy Ravasi)\u003c\/b\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eThe RIKEN mouse transcriptome: lessons learned and implications for the regulation of immune reactions (\u003cb\u003eChristian Schönbach)\u003c\/b\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eMolecular pathways for lymphangiogenesis and their role in human disease (\u003cb\u003eSteven A. Stacker, Rae H. Farnsworth, Tara Karnezis, Ramin Shayan,.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eDarrin P. Smith, Karri Paavonen, Natalia Davydova, Carol Caesar,.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eRachael Inder, Megan E. Baldwin, Bradley K. McColl, Sally Roufail,.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eRichard A. Williams, Richard A. Hughes, Kari Alitalo\u003c\/b\u003e and.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eMarc G. Achen)\u003c\/b\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eGeneral discussion I.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSpecifying the patterns of immune cell migration (\u003cb\u003eJason G. Cyster)\u003c\/b\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eHuman monogenic disorders that confer predisposition to specifi c infections (\u003cb\u003eCapucine Picard, Laurent Abel\u003c\/b\u003e and \u003cb\u003eJean-Laurent Casanova)\u003c\/b\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eThe genetic control of susceptibility to \u003ci\u003eMycobacterium tuberculosis (\u003c\/i\u003e\u003cb\u003eW. J. Britton, S. L. Fernando, B. M. Saunders, R. Sluyter\u003c\/b\u003e and \u003cb\u003eJ. S. Wiley)\u003c\/b\u003e\u003ci\u003e.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eTh2 lymphoproliferative disorders resulting from defective LAT signalosomes (\u003cb\u003eBernard Malissen, Ying Wang, Michael Mingueneau\u003c\/b\u003e and \u003cb\u003eMarie Malissen\u003c\/b\u003e).\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eGenetic analysis of systemic autoimmunity (\u003cb\u003eCarola G. Vinuesa\u003c\/b\u003e and \u003cb\u003eMatthew C. Cook)\u003c\/b\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eGenetic resistance to smallpox: lessons from mousepox (\u003cb\u003eGunasegaran Karupiah, Vijay Panchanathan, Isaac G. Sakala\u003c\/b\u003e and \u003cb\u003eGeeta Chaudhri)\u003c\/b\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eThe AcB\/BcA recombinant congenic strains of mice: strategies for phenotype dissection, mapping and cloning of quantitative trait genes (\u003cb\u003eAnny Fortin, Eduardo Diez, Janet E. Henderson, Jeffrey S. Mogil, Philippe Gros\u003c\/b\u003e and \u003cb\u003eEmil Skamene)\u003c\/b\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eGenetic control of host–pathogen interactions in mice (\u003cb\u003eGundula Min-Oo, Mary M. Stevenson, Anny Fortin\u003c\/b\u003e and \u003cb\u003ePhilippe Gros)\u003c\/b\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eMycobacterium tuberculosis\u003c\/i\u003e and its ability to resist immunity (\u003cb\u003eDouglas Young\u003c\/b\u003e and \u003cb\u003eAnne O’Garra)\u003c\/b\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSystems genetics: the next generation in genetics research? (\u003cb\u003eGrant Morahan\u003c\/b\u003e and \u003cb\u003eRobert W. Williams).\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eRegulation of the immune system in metazoan parasite infections (\u003cb\u003eRick Maizels)\u003c\/b\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eClosing remarks (\u003cb\u003eChris Goodnow)\u003c\/b\u003e.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eContributor Index.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSubject Index.\u003c\/b\u003e\u003c\/p\u003e \"…useful to…researchers and clinicians with a particular interest in pathways of regulation.\" (\u003ci\u003eDoody's Health Services\u003c\/i\u003e) The \u003cb\u003eNovartis Foundation\u003c\/b\u003e is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.  This book explores existing and potential strategies for using the genome sequences of human, mouse, other vertebrates and human pathogens to solve key problems in the treatment of immunological diseases and chronic infections.  The assembled genome sequences now provide important opportunities for solving these problems, but a major bottleneck is the identification of key sequences and circuits controlling the relevant immune reactions.  This will require innovative, interdisciplinary and collaborative strategies of a scale and complexity we are only now beginning to comprehend.  \u003cp\u003eSpecific problems addressed include the following:\u003c\/p\u003e \u003cul type=\"disc\"\u003e \u003cli\u003eWhat kinds of information are we lacking to understand how the genome sequence specifies the differentiation and response of immune system cells, and system behaviour such as immunological memory and tolerance?\u003c\/li\u003e \u003cli\u003eWhich genome sequences and cellular circuits cause or prevent pathological immune responses to foreign pathogens, allergens or self-tissues?\u003c\/li\u003e \u003cli\u003eWhich host and pathogen genome sequences and cellular circuits explain the failure of sterilizing immune responses to sophisticated human pathogens such as the agents of tuberculosis, malaria, metazoan parasites and chronic viruses?\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eContaining contributions from a range of leading experts in the field, this book provides an important new perspective for clinical immunologists and basic researchers alike.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989031403749,"sku":"NP9780470027554","price":211.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470027554.jpg?v=1761782514","url":"https:\/\/k12savings.com\/es\/products\/decoding-the-genomic-control-of-immune-reactions-isbn-9780470027554","provider":"K12savings","version":"1.0","type":"link"}