{"product_id":"cyclic-nucleotide-phosphodiesterases-in-the-central-nervous-system-isbn-9780470566688","title":"Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System","description":"This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these, then focus on the areas of greatest scientific and medical interest to provide more detailed coverage. Therapeutic and drug discovery applications are covered for diseases including Alzheimer's, Parkinson's, schizophrenia, erectile dysfunction, and spinal cord injuries. There is also a chapter on drug discovery tools such as in vitro assays and X-ray structures for medicinal chemistry studies.  \u003cp\u003e\u003ci\u003ePREFACE vii\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eCONTRIBUTORS ix\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 PHOSPHODIESTERASES AND CYCLIC NUCLEOTIDE SIGNALING IN THE CNS 1\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eMarco Conti and Wito Richter\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 PUTTING TOGETHER THE PIECES OF PHOSPHODIESTERASE DISTRIBUTION PATTERNS IN THE BRAIN: A JIGSAW PUZZLE OF CYCLIC NUCLEOTIDE REGULATION 47\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eMichy P. Kelly\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 COMPARTMENTALIZATION AND REGULATION OF CYCLIC NUCLEOTIDE SIGNALING IN THE CNS 59\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eManuela Zaccolo and Alessandra Stangherlin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 PHARMACOLOGICAL MANIPULATION OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE SIGNALING FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS IN THE BRAIN 77\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eFrank S. Menniti, Niels Plath, Niels Svenstrup, and Christopher J. Schmidt\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 RECENT RESULTS IN PHOSPHODIESTERASE INHIBITOR DEVELOPMENT AND CNS APPLICATIONS 115\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eDavid P. Rotella\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 CRYSTAL STRUCTURES OF PHOSPHODIESTERASES AND IMPLICATION ON DISCOVERY OF INHIBITORS 145\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eHengming Ke, Huanchen Wang, Mengchun Ye, and Yingchun Huang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 INHIBITION OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASES TO REGULATE MEMORY 171\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eHan-Ting Zhang, Ying Xu, and James O’Donnell\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 EMERGING ROLE FOR PDE4 IN NEUROPSYCHIATRIC DISORDERS: TRANSLATING ADVANCES FROM GENETIC STUDIES INTO RELEVANT THERAPEUTIC STRATEGIES 211\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eSandra P. Zoubovsky, Nicholas J. Brandon, and Akira Sawa\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 BEYOND ERECTILE DYSFUNCTION: UNDERSTANDING PDE5 ACTIVITY IN THE CENTRAL NERVOUS SYSTEM 223\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eEva P.P. Bollen, Kris Rutten, Olga A.H. Reneerkens, Harry M.W. Steinbusch, and Jos Prickaerts\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 MOLECULAR AND CELLULAR UNDERSTANDING OF PDE10A: A DUAL-SUBSTRATE PHOSPHODIESTERASE WITH THERAPEUTIC POTENTIAL TO MODULATE BASAL\u003c\/b\u003e \u003cb\u003eGANGLIA FUNCTION 247\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eErik I. Charych and Nicholas J. Brandon\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 ROLE OF CYCLIC NUCLEOTIDE SIGNALING AND PHOSPHODIESTERASE ACTIVATION IN THE\u003c\/b\u003e\u003cbr\u003e \u003cb\u003eMODULATION OF ELECTROPHYSIOLOGICAL ACTIVITY OF CENTRAL NEURONS 269\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eSarah Threlfell and Anthony R. West\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 THE ROLE OF PHOSPHODIESTERASES IN DOPAMINE SYSTEMS GOVERNING MOTIVATED BEHAVIOR 303\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eGretchen L. Snyder, Joseph P. Hendrick, and Akinori Nishi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 INHIBITION OF PHOSPHODIESTERASES AS A STRATEGY FOR TREATMENT OF SPINAL CORD INJURY 353\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eElena Nikulina and Marie T. Filbin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eINDEX 375\u003c\/i\u003e\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eNICHOLAS BRANDON\u003c\/b\u003e works at AstraZeneca within the Neuroscience Innovative Medicines Group. He has spent his career in drug discovery with a strong interest in developing phosphodiesterase inhibitors for neuropsychiatric disorders and understanding the basic mechanisms of phosphodiesterase function.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eANTHONY WEST\u003c\/b\u003e is an Associate Professor in the Department of Neuroscience at Rosalind Franklin University. He has studied PDE function in the basal ganglia for over fifteen years, focusing on neurochemical and electrophysiological changes induced by PDE inhibitors in the healthy brain and in animal models of Parkinson’s disease and Huntington’s disease.\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eMethods and advances for understanding phosphodiesterases (PDEs), a hot area of drug and therapeutic research\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eCyclic-nucleotide phosphodiesterases (PDEs) are critical for the regulation of processes from cell birth to cell death, but diseases of the central nervous system (CNS) often disrupt these essential functions. \u003ci\u003eCyclic-Nucleotide Phosphodiesterases in the Central Nervous System: From Biology to Drug Discovery\u003c\/i\u003e helps scientists understand the concepts to develop more selective and potent inhibitors and modulators as treatments for neurological diseases. A number of expert authors from both academia and industry capture these principles by focusing on the areas of greatest scientific and medical interest.\u003c\/p\u003e \u003cp\u003eWhile explaining the science behind PDEs, this book provides readers with:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eAnalytical tools for translating biological knowledge and developing inhibitors and modulators of PDE\u003c\/li\u003e \u003cli\u003eThe expertise of leading researchers from both basic and applied sciences\u003c\/li\u003e \u003cli\u003eDiscussion about PDE biology and enzymology with respect to the brain and spinal cord\u003c\/li\u003e \u003cli\u003eKnowledge for developing treatments for specific CNS diseases like schizophrenia, Alzheimer’s, Parkinson’s, depression, and spinal cord injuries\u003c\/li\u003e \u003cli\u003eInformation about drug discovery tools, such as in vitro assays and X-ray structures, for medicinal chemistry\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eAs a comprehensive and advanced guide that applies to both academic and industry research, this book helps readers discover strategies and insights into PDE biology and chemistry, therapeutic approaches and opportunities, and novel medicines.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989020000485,"sku":"NP9780470566688","price":144.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470566688.jpg?v=1761782466","url":"https:\/\/k12savings.com\/es\/products\/cyclic-nucleotide-phosphodiesterases-in-the-central-nervous-system-isbn-9780470566688","provider":"K12savings","version":"1.0","type":"link"}