{"product_id":"crispr-isbn-9781683670377","title":"CRISPR","description":"\u003cp\u003e\u003cb\u003e“\u003ci\u003eAn excellent compendium of all things CRISPR from some of the leading minds in the field. With thorough coverage from every angle and beautifully detailed illustrations, this book is not to be missed!\u003c\/i\u003e” \u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eJennifer A. Doudna, \u003c\/b\u003e\u003cbr\u003eProfessor of Chemistry, Biochemistry \u0026amp; Molecular Biology, UC Berkeley; Founder, Innovative Genomics Institute; Nobel Laureate and coinventor of CRISPR technology\u003c\/p\u003e \u003cp\u003e\u003cb\u003e“\u003ci\u003eThis journey through CRISPR biology and several of its breakthrough applications offers an exciting glimpse into one of the most beautiful and compelling fields in the life sciences.\u003c\/i\u003e” \u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eDavid R. Liu,\u003c\/b\u003e\u003cbr\u003eDirector of the Merkin Institute at the Broad Institute of MIT and Harvard; Professor of Chemistry and Chemical Biology at Harvard University; coinventor of base editing and prime editing\u003c\/p\u003e \u003cp\u003e\u003cb\u003e“\u003ci\u003eA must read! The CRISPR topics, written by world-leading experts, span from the fascinating mechanistic underpinnings to the ingenious applications. One can read from start to finish or pick and choose themes. Either way, the book delivers utterly enjoyable learning!\u003c\/i\u003e” \u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eBonnie Bassler, \u003c\/b\u003e\u003cbr\u003eSquibb Professor and Chair, Princeton University Department of Molecular Biology; Howard Hughes Medical Institute Investigator\u003c\/p\u003e \u003cp\u003eCRISPR-Cas systems have revolutionized the science of gene editing and their possible applications continue to expand, from basic research to potentially groundbreaking medical and commercial uses.\u003c\/p\u003e \u003cp\u003eLed by a distinguished team of editors, \u003ci\u003eCRISPR: Biology and Applications\u003c\/i\u003e explores the subject matter needed to delve into this fascinating area. Topics covered include:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eClassification and molecular mechanisms of CRISPR-Cas systems\u003c\/li\u003e \u003cli\u003eCRISPR-Cas evolution, regulation, expression, and function\u003c\/li\u003e \u003cli\u003eUses for gene editing and modulation of gene expression\u003c\/li\u003e \u003cli\u003eCRISPR-based antimicrobials and phage resistance for medical and industrial purposes\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eWritten by internationally renowned authors, \u003ci\u003eCRISPR: Biology and Applications\u003c\/i\u003e serves as both an introductory guide for those new to the field and an authoritative reference for seasoned researchers whose work touches this evolving and headline- making science.\u003c\/p\u003e \u003cp\u003eContributors vii\u003cbr\u003e Preface xi\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection I\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eDiversity of CRISPR‐Cas Systems 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 CRISPR-Cas Systems: Core Features and Common Mechanisms 3\u003cbr\u003e \u003ci\u003eRodolphe Barrangou, Luciano A. Marraffini, and Erik J. Sontheimer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Evolutionary Classification of CRISPR-Cas Systems 13\u003cbr\u003e \u003ci\u003eKira S. Makarova, Yuri I. Wolf, and Eugene V. Koonin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Molecular Mechanisms of Type I CRISPR-Cas Systems 39\u003cbr\u003e \u003ci\u003eJohn van der Oost\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Molecular Mechanisms of Type II CRISPR‐Cas Systems 53\u003cbr\u003e \u003ci\u003eTautvydas Karvelis and Virginijus Siksnys\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Mechanism of Type III CRISPR‐Cas Immunity 71\u003cbr\u003e \u003ci\u003eLuciano A. Marraffini\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Type V CRISPR‐Cas Systems 85\u003cbr\u003e \u003ci\u003eMorgan Quinn Beckett, Anita Ramachandran, and Scott Bailey\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 CRISPR-Cas13: Biology, Mechanism, and Applications of RNA-Guided, RNA-Targeting CRISPR Systems 99\u003cbr\u003e \u003ci\u003eOmar O. Abudayyeh and Jonathan S. Gootenberg \u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection II\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eCRISPR‐Cas Biology 121\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8 CRISPR-Cas, Horizontal Gene Transfer, and the Flexible (Pan) Genome 123\u003cbr\u003e \u003ci\u003eUri Gophna\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Evasion Tactics Manifested by Bacteriophages against Bacterial Immunity 131\u003cbr\u003e \u003ci\u003eJenny Y. Zhang, Sutharsan Govindarajan, and Joseph Bondy-Denomy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Regulation of CRISPR‐Cas Expression and Function 145\u003cbr\u003e \u003ci\u003eLeah M. Smith, Aroa Rey Campa, and Peter C. Fineran\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection III\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eCRISPR‐Based Technologies and Applications 163\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11 Genome Editing with CRISPR‐Cas Systems 165\u003cbr\u003e \u003ci\u003ePeter Lotfy and Patrick D. Hsu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Genetic and Epigenetic Modulation of Gene Expression by CRISPR-dCas Systems 195\u003cbr\u003e \u003ci\u003eJasprina N. Noordermeer, Crystal Chen, and Lei S. Qi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 CRISPR Screens 213\u003cbr\u003e \u003ci\u003eJonathan D. D’Gama, Joseph S. Park, and Matthew K. Waldor\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 CRISPR‐Based Antimicrobials 233\u003cbr\u003e \u003ci\u003eJusten Russell and David Bikard\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Exploiting CRISPR‐Cas Systems To Provide Phage Resistance in Industrial Bacteria 249\u003cbr\u003e \u003ci\u003eRodolphe Barrangou and Avery Roberts\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Recording Biological Information with CRISPR‐Cas Systems 267\u003cb\u003e\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eMariia Y. Cherepkova, Tanmay Tanna, and Randall J. Platt\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eAfterword 281\u003c\/p\u003e \u003cp\u003eIndex 283\u003c\/p\u003e \u003cp\u003e\u003cb\u003e ABOUT THE EDITORS \u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eRodolphe Barrangou\u003c\/b\u003e is the Todd R. Klaenhammer Distinguished Professor in the Department of Food, Bioprocessing and Nutrition Sciences at North Carolina State University; a member of the AAM, NAS, NAE, and NAI; a cofounder of Intellia Therapeutics, Locus Biosciences, Ancilia Biosciences, CRISPR Biotechnologies, and TreeCo; and Editor- in-Chief of \u003ci\u003eThe CRISPR Journal.\u003c\/i\u003e \u003c\/p\u003e\u003cp\u003e\u003cb\u003eErik J. Sontheimer\u003c\/b\u003e is the Pillar Chair in Biomedical Research and Professor in the RNA Therapeutics Institute at the University of Massachusetts Chan Medical School; an Associate Editor of \u003ci\u003eRNA\u003c\/i\u003e; a member of the AAM; a cofounder of Intellia Therapeutics; and a Scientific Advisory Board member at Tessera Therapeutics.  \u003c\/p\u003e\u003cp\u003e\u003cb\u003eLuciano A. Marraffini\u003c\/b\u003e is the Kayden Family Professor and Head of the Laboratory of Bacteriology at The Rockefeller University; a Howard Hughes Medical Institute Investigator; a member of the AAM, AAAS, and NAS; and a cofounder of Intellia Therapeutics, CRISPR Biotechnologies, and Eligo Biosciences.  \u003c\/p\u003e\u003cp\u003e\u003cb\u003eCRISPR: BIOLOGY AND APPLICATIONS \u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e\"An excellent compendium of all things CRISPR from some of the leading minds in the field. With thorough coverage from every angle and beautifully detailed illustrations, this book is not to be missed!\"\u003cbr\u003e—\u003c\/b\u003e\u003cb\u003eJennifer A. Doudna, \u003c\/b\u003eProfessor of Chemistry, Biochemistry \u0026amp; Molecular Biology, UC Berkeley; Founder, Innovative Genomics Institute; Nobel Laureate and coinventor of CRISPR technology\u003c\/p\u003e \u003cp\u003e\u003cb\u003e\"This journey through CRISPR biology and several of its breakthrough applications offers an exciting glimpse into one of the most beautiful and compelling fields in the life sciences.\"\u003cbr\u003e—\u003c\/b\u003e\u003cb\u003eDavid R. Liu, \u003c\/b\u003eDirector of the Merkin Institute at the Broad Institute of MIT and Harvard; Professor of Chemistry and Chemical Biology at Harvard University; coinventor of base editing and prime editing\u003c\/p\u003e \u003cp\u003e\u003cb\u003e\"A must read! The CRISPR topics, written by world-leading experts, span from the fascinating mechanistic underpinnings to the ingenious applications. One can read from start to finish or pick and choose themes. Either way, the book delivers utterly enjoyable learning!\"\u003cbr\u003e—\u003c\/b\u003e\u003cb\u003eBonnie Bassler, \u003c\/b\u003eSquibb Professor and Chair, Princeton University Department of Molecular Biology; Howard Hughes Medical Institute Investigator\u003c\/p\u003e \u003cp\u003eCRISPR-Cas systems have revolutionized the science of gene editing and their possible applications continue to expand, from basic research to potentially groundbreaking medical and commercial uses.\u003c\/p\u003e \u003cp\u003eLed by a distinguished team of editors, \u003ci\u003eCRISPR: Biology and Applications\u003c\/i\u003e explores the subject matter needed to delve into this fascinating area. Topics covered include:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eClassification and molecular mechanisms of CRISPR-Cas systems\u003c\/li\u003e \u003cli\u003eCRISPR-Cas evolution, regulation, expression, and function\u003c\/li\u003e \u003cli\u003eUses for gene editing and modulation of gene expression\u003c\/li\u003e \u003cli\u003eCRISPR-based antimicrobials and phage resistance for medical and industrial purposes\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eWritten by internationally renowned authors, \u003ci\u003eCRISPR: Biology and Applications\u003c\/i\u003e serves as both an introductory guide for those new to the field and an authoritative reference for seasoned researchers whose work touches this evolving and headline- making science.\u003c\/p\u003e","brand":"ASM Press","offers":[{"title":"Default Title","offer_id":47989005353189,"sku":"NP9781683670377","price":140.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781683670377.jpg?v=1761782399","url":"https:\/\/k12savings.com\/es\/products\/crispr-isbn-9781683670377","provider":"K12savings","version":"1.0","type":"link"}