{"product_id":"comparative-pharmacokinetics-isbn-9780813829937","title":"Comparative Pharmacokinetics","description":"Now in a revised edition, \u003ci\u003eComparative Pharmacokinetics: Principles, Techniques, and Applications\u003c\/i\u003e presents the principles and techniques of comparative and veterinary pharmacokinetics in a detailed yet practical manner. Developed as a tool for ensuring that pharmacokinetics studies are properly designed and correctly interpreted, the book provides complete coverage of the conceptual basis of pharmacokinetics as used for quantifying biological processes from the perspectives of physiology and medicine.  New chapters have been added on quantitative structure permeability relationships and bioequivalence, and a number of existing chapters have been significantly revised and expanded to provide a current resource for veterinary and comparative pharmacokinetics.  \u003ci\u003eCoauthors.\u003c\/i\u003e  \u003cp\u003e\u003ci\u003ePreface.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1 Introduction.\u003c\/p\u003e \u003cp\u003e2 Principles of Drug Movement in the Body.\u003c\/p\u003e \u003cp\u003e3 Quantitative Structure–Permeability Relationships \u003ci\u003e(Xin-Rui Xia).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Absorption.\u003c\/p\u003e \u003cp\u003e5 Distribution \u003ci\u003e(with Jennifer Buur).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Renal Elimination.\u003c\/p\u003e \u003cp\u003e7 Hepatic Biotransformation and Biliary Excretion \u003ci\u003e(Ronald Baynes).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Compartmental Models.\u003c\/p\u003e \u003cp\u003e9 Noncompartmental Models.\u003c\/p\u003e \u003cp\u003e10 Nonlinear Models.\u003c\/p\u003e \u003cp\u003e11 Physiological Models \u003ci\u003e(Teresa Leavens).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Dosage Regimens.\u003c\/p\u003e \u003cp\u003e13 Simultaneous Pharmacokinetic–Pharmacodynamic Modeling \u003ci\u003e(Pierre-Louis Toutain).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Study Design and Data Analysis. \u003ci\u003e(Jason Chittenden).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Bioequivalence Studies \u003ci\u003e(Marilyn Martinez).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Population Pharmacokinetic Models \u003ci\u003e(Jason Chittenden).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 Dosage Adjustments in Disease States \u003ci\u003e(Jennifer Davis).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 Interspecies Extrapolations.\u003c\/p\u003e \u003cp\u003e19 Tissue Residues and Withdrawal Times \u003ci\u003e(Sharon Mason).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex.\u003c\/p\u003e  \"This book is helpful in understanding and designing pharmacokinetic studies, illustrating basic concepts and noting the species differences. . . The book does a good job of explaining a concept and then expands with more specific examples. It provides a good base for pharmacokinetic modeling and illustrates the pitfalls with interspecies extrapolation.\" (Doody's, 21 October 2011)  \u003cp\u003e \u003c\/p\u003e \u003cb\u003eJim Riviere\u003c\/b\u003e, DVM, PhD, DSc (\u003ci\u003ehon\u003c\/i\u003e), ATS, is the Burroughs Wellcome Fund Distinguished Professor of Pharmacology, Alumni Distinguished Graduate Professor, and Director of the Center for Chemical Toxicology Research and Pharmacokinetics at North Carolina State University, and Editor of the Journal of Veterinary Pharmacology and Therapeutics. \u003cp\u003eNow in a revised edition, \u003ci\u003eComparative Pharmacokinetics: Principles, Techniques, and Applications\u003c\/i\u003e presents the principles and techniques of comparative and veterinary pharmacokinetics in a detailed yet practical manner. Designed as a tool for ensuring that pharmacokinetics studies are properly designed and correctly interpreted, the book provides complete coverage of the conceptual basis of pharmacokinetics as used for quantifying biological processes from the perspectives of physiology and medicine. New chapters have been added on quantitative structure permeability relationships and bioequivalence, and a number of existing chapters have been significantly revised and expanded to provide a current resource for veterinary and comparative pharmacokinetics.\u003c\/p\u003e \u003cp\u003eThe second edition retains the structure of the first, beginning with the basic principles of physiology and then moving into the primary approaches used in pharmacokinetic modeling, including extensive coverage of dosage regimens and adjustments, interspecies extrapolation, experimental design, data collection and analysis, and residues and withdrawal times. With broad human and animal species coverage, \u003ci\u003eComparative Pharmacokinetics\u003c\/i\u003e is essential reading for those working in drug research and development, as well as those with advanced interest in pharmacology and toxicology in veterinary or comparative medicine.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eKey features\u003c\/b\u003e\u003c\/p\u003e \u003cul\u003e \u003cli\u003eProvides a detailed but understandable reference on the conceptual basis of veterinary and comparative pharmacokinetics\u003c\/li\u003e \u003cli\u003eCovers practical applications to both animal and human medicine\u003c\/li\u003e \u003cli\u003eOffers essential information for ensuring that pharmacokinetics studies are correctly designed and interpreted\u003c\/li\u003e \u003cli\u003eIncludes new chapters on quantitative structure permeability relationships and bioequivalence, as well as fully revised and expanded chapters throughout\u003c\/li\u003e \u003cli\u003ePresents a fully rewritten chapter on simultaneous pharmacokinetic-pharmacodynamic modeling to reflect its newly widespread role in comparative medicine\u003c\/li\u003e \u003cli\u003eFacilitates the reader in making conceptual linkages between theory and applications with expanded cross-referencing between topics\u003c\/li\u003e \u003c\/ul\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47988956135653,"sku":"NP9780813829937","price":203.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780813829937.jpg?v=1761782201","url":"https:\/\/k12savings.com\/es\/products\/comparative-pharmacokinetics-isbn-9780813829937","provider":"K12savings","version":"1.0","type":"link"}