{"product_id":"click-chemistry-for-biotechnology-and-materials-science-isbn-9780470699706","title":"Click Chemistry for Biotechnology and Materials Science","description":"Mimicking natural biochemical processes, click chemistry is a modular approach to organic synthesis, joining together small chemical units quickly, efficiently and predictably. In contrast to complex traditional synthesis, click reactions offer high selectivity and yields, near-perfect reliability and exceptional tolerance towards a wide range of functional groups and reaction conditions. These ‘spring loaded’ reactions are achieved by using a high thermodynamic driving force, and are attracting tremendous attention throughout the chemical community. Originally introduced with the focus on drug discovery, the concept has been successfully applied to materials science, polymer chemistry and biotechnology. \u003cp\u003eThe first book to consider this topic\u003ci\u003e, Click Chemistry for Biotechnology and Materials Science\u003c\/i\u003e examines the fundamentals of click chemistry, its application to the precise design and synthesis of macromolecules, and its numerous applications in materials science and biotechnology. The book surveys the current research, discusses emerging trends and future applications, and provides an important nucleation point for research.\u003c\/p\u003e \u003cp\u003eEdited by one of the top 100 young innovators with the greatest potential to have an impact on technology in the 21st century according to Technology Review and with contributions from pioneers in the field, \u003ci\u003eClick Chemistry for Biotechnology and Materials Science\u003c\/i\u003e provides an ideal reference for anyone wanting to learn more about click reactions.\u003c\/p\u003e \u003cp\u003ePreface xiii\u003c\/p\u003e \u003cp\u003eList of Contributors xv\u003c\/p\u003e \u003cp\u003eAcknowledgments xix\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Click Chemistry: A Universal Ligation Strategy for Biotechnology and Materials Science 1\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eJoerg Lahann\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction 1\u003c\/p\u003e \u003cp\u003e1.2 Selected Examples of Click Reactions in Materials Science and Biotechnology 2\u003c\/p\u003e \u003cp\u003e1.3 Potential Limitations of Click Chemistry 5\u003c\/p\u003e \u003cp\u003e1.4 Conclusions 5\u003c\/p\u003e \u003cp\u003eReferences 6\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Common Synthons for Click Chemistry in Biotechnology 9\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eChristine Schilling, Nicole Jung and Stefan Bräse\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction – Click Chemistry 9\u003c\/p\u003e \u003cp\u003e2.2 Peptides and Derivatives 10\u003c\/p\u003e \u003cp\u003e2.3 Peptoids 12\u003c\/p\u003e \u003cp\u003e2.4 Peptidic Dendrimers 13\u003c\/p\u003e \u003cp\u003e2.5 Oligonucleotides 14\u003c\/p\u003e \u003cp\u003e2.6 Carbohydrates 18\u003c\/p\u003e \u003cp\u003e2.7 Conclusion 25\u003c\/p\u003e \u003cp\u003eReferences 26\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Copper-free Click Chemistry 29\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eJeremy M. Baskin and Carolyn R. Bertozzi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction 29\u003c\/p\u003e \u003cp\u003e3.2 Bio-orthogonal Ligations 30\u003c\/p\u003e \u003cp\u003e3.2.1 Condensations of Ketones and Aldehydes with Heteroatom-bound Amines 31\u003c\/p\u003e \u003cp\u003e3.2.2 Staudinger Ligation of Phosphines and Azides 32\u003c\/p\u003e \u003cp\u003e3.2.3 Copper-free Azide–Alkyne Cycloadditions 35\u003c\/p\u003e \u003cp\u003e3.2.4 Bioorthogonal Ligations of Alkenes 37\u003c\/p\u003e \u003cp\u003e3.3 Applications of Copper-free Click Chemistries 38\u003c\/p\u003e \u003cp\u003e3.3.1 Activity-based Profiling of Enzymes 38\u003c\/p\u003e \u003cp\u003e3.3.2 Site-specific Labeling of Proteins 39\u003c\/p\u003e \u003cp\u003e3.3.3 Metabolic Labeling of Glycans 41\u003c\/p\u003e \u003cp\u003e3.3.4 Metabolic Targeting of Other Biomolecules with Chemical Reporters 44\u003c\/p\u003e \u003cp\u003e3.4 Summary and Outlook 45\u003c\/p\u003e \u003cp\u003eReferences 46\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Protein and Peptide Conjugation to Polymers and Surfaces Using Oxime Chemistry 53\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eHeather D. Maynard, Rebecca M. Broyer and Christopher M. Kolodziej\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 53\u003c\/p\u003e \u003cp\u003e4.2 Protein\/Peptide–Polymer Conjugates 54\u003c\/p\u003e \u003cp\u003e4.3 Immobilization of Proteins and Peptides on Surfaces 60\u003c\/p\u003e \u003cp\u003e4.4 Conclusions 66\u003c\/p\u003e \u003cp\u003eReferences 67\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 The Role of Click Chemistry in Polymer Synthesis 69\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eJean-François Lutz and Brent S. Sumerlin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 69\u003c\/p\u003e \u003cp\u003e5.2 Polymerization via CuAAC 70\u003c\/p\u003e \u003cp\u003e5.3 Post-polymerization Modification via Click Chemistry 72\u003c\/p\u003e \u003cp\u003e5.4 Polymer–Biomacromolecule Conjugation 76\u003c\/p\u003e \u003cp\u003e5.5 Functional Nanomaterials 81\u003c\/p\u003e \u003cp\u003e5.6 Summary and Outlook 83\u003c\/p\u003e \u003cp\u003eReferences 85\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Blocks, Stars and Combs: Complex Macromolecular Architecture Polymers via Click Chemistry 89\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eSebastian Sinnwell, Andrew J. Inglis, Martina H. Stenzel and Christopher Barner-Kowollik\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 89\u003c\/p\u003e \u003cp\u003e6.2 Block Copolymers 91\u003c\/p\u003e \u003cp\u003e6.2.1 Preparing Polymers for Click Conjugations 92\u003c\/p\u003e \u003cp\u003e6.2.2 The Click Reaction: Methodologies and Isolation 96\u003c\/p\u003e \u003cp\u003e6.2.3 Polymer Characterization 99\u003c\/p\u003e \u003cp\u003e6.3 Star Polymers 101\u003c\/p\u003e \u003cp\u003e6.3.1 Star polymers A\u003csub\u003en\u003c\/sub\u003e 101\u003c\/p\u003e \u003cp\u003e6.3.2 Dentritic Star Polymers 107\u003c\/p\u003e \u003cp\u003e6.4 Graft Copolymers 107\u003c\/p\u003e \u003cp\u003e6.4.1 ‘Grafting-to’ Azide Main Chains 109\u003c\/p\u003e \u003cp\u003e6.4.2 ‘Grafting-to’ Alkyne Main Chains 111\u003c\/p\u003e \u003cp\u003e6.4.3 Non-CuAAC Routes 113\u003c\/p\u003e \u003cp\u003e6.5 Concluding Remarks 113\u003c\/p\u003e \u003cp\u003eReferences 113\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Click Chemistry on Supramolecular Materials 119\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eWolfgang H. Binder and Robert Sachsenhofer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 119\u003c\/p\u003e \u003cp\u003e7.2 Click Reactions on Rotaxanes, Cyclodextrines and Macrocycles 123\u003c\/p\u003e \u003cp\u003e7.2.1 Click with Rotaxanes 123\u003c\/p\u003e \u003cp\u003e7.2.2 Click on Cyclodextrines 126\u003c\/p\u003e \u003cp\u003e7.2.3 Click on Macrocycles 128\u003c\/p\u003e \u003cp\u003e7.3 Click Reactions on DNA 131\u003c\/p\u003e \u003cp\u003e7.4 Click Reactions on Supramolecular Polymers 138\u003c\/p\u003e \u003cp\u003e7.5 Click Reactions on Membranes 143\u003c\/p\u003e \u003cp\u003e7.6 Click Reactions on Dendrimers 147\u003c\/p\u003e \u003cp\u003e7.7 Click Reactions on Gels and Networks 147\u003c\/p\u003e \u003cp\u003e7.8 Click Reactions on Self-assembled Monolayers 153\u003c\/p\u003e \u003cp\u003eReferences 164\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Dendrimer Synthesis and Functionalization by Click Chemistry for Biomedical Applications 177\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eDaniel Q. McNerny, Douglas G. Mullen, Istvan J. Majoros, Mark M. Banaszak Holl and James R. Baker Jr\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 177\u003c\/p\u003e \u003cp\u003e8.2 Dendrimer Synthesis 181\u003c\/p\u003e \u003cp\u003e8.2.1 Divergent Synthesis 181\u003c\/p\u003e \u003cp\u003e8.2.2 Convergent Synthesis 183\u003c\/p\u003e \u003cp\u003e8.3 Dendrimer Functionalization 184\u003c\/p\u003e \u003cp\u003e8.4 Conclusions and Future Directions 189\u003c\/p\u003e \u003cp\u003eReferences 191\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Reversible Diels–Alder Cycloaddition for the Design of Multifunctional Network Polymers 195\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eAmy M. Peterson and Giuseppe R. Palmese\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 195\u003c\/p\u003e \u003cp\u003e9.2 Design of Polymer Networks 198\u003c\/p\u003e \u003cp\u003e9.3 Application of Diels–Alder Linkages to Polymer Systems 199\u003c\/p\u003e \u003cp\u003e9.3.1 Molecular Weight Control of Linear Polymers 200\u003c\/p\u003e \u003cp\u003e9.3.2 Remoldable Crosslinked Materials 202\u003c\/p\u003e \u003cp\u003e9.3.3 Thermally Removable Encapsulants 203\u003c\/p\u003e \u003cp\u003e9.3.4 Reversibly Crosslinked Polymer–Solvent Gels 203\u003c\/p\u003e \u003cp\u003e9.3.5 Remendable Materials 204\u003c\/p\u003e \u003cp\u003e9.3.6 Recyclable Thermosets 206\u003c\/p\u003e \u003cp\u003e9.3.7 Smart Materials 207\u003c\/p\u003e \u003cp\u003e9.4 Conclusions 209\u003c\/p\u003e \u003cp\u003eReferences 209\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Click Chemistry in the Preparation of Biohybrid Materials 217\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eHeather J. Kitto, Jan Lauko, Floris P. J. T. Rutjes and Alan E. Rowan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 217\u003c\/p\u003e \u003cp\u003e10.2 Polymer-containing Biohybrid Materials 218\u003c\/p\u003e \u003cp\u003e10.2.1 Polymers from Controlled Techniques 218\u003c\/p\u003e \u003cp\u003e10.2.2 Bio-inspired Polymers via Click Chemistry 220\u003c\/p\u003e \u003cp\u003e10.3 Biohybrid Structures based on Protein Conjugates 228\u003c\/p\u003e \u003cp\u003e10.4 Biohybrid Amphiphiles 232\u003c\/p\u003e \u003cp\u003e10.5 Glycoconjugates 236\u003c\/p\u003e \u003cp\u003e10.5.1 Carbohydrate Clusters 236\u003c\/p\u003e \u003cp\u003e10.5.2 Glycopeptides 238\u003c\/p\u003e \u003cp\u003e10.5.3 Glycopolymers 244\u003c\/p\u003e \u003cp\u003e10.6 Conclusions 247\u003c\/p\u003e \u003cp\u003eReferences 247\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Functional Nanomaterials using the Cu-catalyzed Huisgen Cycloaddition Reaction 255\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eSander S. van Berkel, Arnold W.G. Nijhuis, Dennis W.P.M. Löwik and Jan C.M. van Hest\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction 255\u003c\/p\u003e \u003cp\u003e11.2 Inorganic Nanoparticles 256\u003c\/p\u003e \u003cp\u003e11.2.1 Silicon-based Nanoparticles 256\u003c\/p\u003e \u003cp\u003e11.2.2 Cadmium Selenide-based Nanoparticles 257\u003c\/p\u003e \u003cp\u003e11.2.3 Ferric Oxide-based Nanoparticles 257\u003c\/p\u003e \u003cp\u003e11.2.4 Gold-based Nanoparticles 261\u003c\/p\u003e \u003cp\u003e11.3 Carbon-based Nanomaterials 266\u003c\/p\u003e \u003cp\u003e11.3.1 Fullerenes 267\u003c\/p\u003e \u003cp\u003e11.3.2 Carbon Nanotubes 269\u003c\/p\u003e \u003cp\u003e11.4 Self-assembled Organic Structures 272\u003c\/p\u003e \u003cp\u003e11.4.1 Liposomes 274\u003c\/p\u003e \u003cp\u003e11.4.2 Polymersomes 275\u003c\/p\u003e \u003cp\u003e11.4.3 Micelles and Cross-linked Nanoparticles 278\u003c\/p\u003e \u003cp\u003e11.5 Virus Particles 281\u003c\/p\u003e \u003cp\u003e11.6 Conclusions 284\u003c\/p\u003e \u003cp\u003eReferences 285\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Copper-catalyzed ‘Click’ Chemistry for Surface Engineering 291\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eHimabindu Nandivada and Joerg Lahann\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 291\u003c\/p\u003e \u003cp\u003e12.2 Synthesis of Alkyne or Azide-functionalized Surfaces 292\u003c\/p\u003e \u003cp\u003e12.2.1 Self-assembled Monolayers of Alkanethiolates 292\u003c\/p\u003e \u003cp\u003e12.2.2 Self-assembled Monolayers of Silanes and Siloxanes 292\u003c\/p\u003e \u003cp\u003e12.2.3 Block Copolymers 294\u003c\/p\u003e \u003cp\u003e12.2.4 Layer-by-layer Films 296\u003c\/p\u003e \u003cp\u003e12.2.5 Chemical Vapor Deposition Polymerization 297\u003c\/p\u003e \u003cp\u003e12.2.6 Fiber Networks 298\u003c\/p\u003e \u003cp\u003e12.3 Spatially Controlled Click Chemistry 299\u003c\/p\u003e \u003cp\u003e12.4 Copper-catalyzed Click Chemistry for Bioimmobilization 300\u003c\/p\u003e \u003cp\u003e12.5 Summary 305\u003c\/p\u003e \u003cp\u003eReferences 305\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Click Chemistry in Protein Engineering, Design, Detection and Profiling 309\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eDaniela C. Dieterich and A. James Link\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction 309\u003c\/p\u003e \u003cp\u003e13.2 Posttranslational Functionalization of Proteins with Azides and Alkynes 310\u003c\/p\u003e \u003cp\u003e13.3 Cotranslational Functionalization of Proteins with Azides and Alkynes 314\u003c\/p\u003e \u003cp\u003e13.4 BONCAT: Identification of Newly Synthesized Proteins via Noncanonical Amino Acid Tagging 318\u003c\/p\u003e \u003cp\u003e13.5 Conclusions and Future Prospects 321\u003c\/p\u003e \u003cp\u003eReferences 322\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Fluorogenic Copper(I)-catalyzed Azide–Alkyne Cycloaddition Reactions Reactions and their Applications in Bioconjugation 327\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eCéline Le Droumaguet and Qian Wang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Click Reaction for Bioconjugation Applications 327\u003c\/p\u003e \u003cp\u003e14.2 Significance of Fluorogenic Reactions in Bioconjugation 328\u003c\/p\u003e \u003cp\u003e14.3 CuAAC-based Fluorogenic Reaction 332\u003c\/p\u003e \u003cp\u003e14.4 Applications of CuAAC in Bioconjugation 337\u003c\/p\u003e \u003cp\u003e14.4.1 Fluorogenic Probing of Cellular Components 339\u003c\/p\u003e \u003cp\u003e14.4.2 Fluorogenic Conjugation of DNA 341\u003c\/p\u003e \u003cp\u003e14.4.3 Fluorogenic Conjugation of Viruses 344\u003c\/p\u003e \u003cp\u003e14.4.4 Fluorogenic Conjugation of Nanoparticles\/Polymers 345\u003c\/p\u003e \u003cp\u003e14.5 Conclusions 348\u003c\/p\u003e \u003cp\u003eReferences 349\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Synthesis and Functionalization of Biomolecules via Click Chemistry 355\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eChristine Schilling, Nicole Jung and Stefan Bräse\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15.1 Introduction 355\u003c\/p\u003e \u003cp\u003e15.2 Labeling of Macromolecular Biomolecules 356\u003c\/p\u003e \u003cp\u003e15.2.1 Fluorescent Labeling 356\u003c\/p\u003e \u003cp\u003e15.2.2 Labeling of Bovine Serum Albumin 360\u003c\/p\u003e \u003cp\u003e15.2.3 Biotin-labeling of Biomolecules: ABPP 361\u003c\/p\u003e \u003cp\u003e15.2.4 Fluorine Labeling 364\u003c\/p\u003e \u003cp\u003e15.3 Syntheses of Natural Products and Derivatives 365\u003c\/p\u003e \u003cp\u003e15.4 Enzymes and Click Chemistry 368\u003c\/p\u003e \u003cp\u003e15.5 Synthesis of Glycosylated Molecular Architectures 371\u003c\/p\u003e \u003cp\u003e15.6 Synthesis of Nitrogen-rich Compounds: Polyazides and Triazoles 373\u003c\/p\u003e \u003cp\u003e15.7 Conclusions 374\u003c\/p\u003e \u003cp\u003eReferences 375\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 Unprecedented Electro-optic Properties in Polymers and Dendrimers Enabled by Click Chemistry Based on the Diels–Alder Reactions 379\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eJingdong Luo, Tae-Dong Kim and Alex K.-Y. Jen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16.1 Introduction 379\u003c\/p\u003e \u003cp\u003e16.2 Diels–Alder Click Chemistry for Highly Efficient Side-chain E-O Polymers 380\u003c\/p\u003e \u003cp\u003e16.3 Diels–Alder Click Chemistry for Crosslinkable E-O Polymers Containing Binary NLO Chromophores 388\u003c\/p\u003e \u003cp\u003e16.4 Diels–Alder Click Chemistry for NLO Dendrimers 392\u003c\/p\u003e \u003cp\u003e16.5 Conclusions 394\u003c\/p\u003e \u003cp\u003eReferences 397\u003c\/p\u003e \u003cp\u003eIndex 399\u003c\/p\u003e  \"This book is a high-quality reference for people working in the field or for people interested in using click chemistry in biotechnology and\/or materials science.\" (\u003ci\u003eAngewandte Chemie\u003c\/i\u003e, 2010)\u003cbr\u003e \u003cbr\u003e   \u003cp\u003e \u003c\/p\u003e \"This book should remain an essential reference source for many years.\" (\u003ci\u003eChemistry World\u003c\/i\u003e, April 2010)  \u003cp\u003e\u003cstrong\u003eJoerg Lahann\u003c\/strong\u003e is Dow Corning Assistant Professor in the Chemical Engineering Department at the University of Michigan (USA). He was educated at the University of Saarland (Germany) and obtained his PhD at RWTH Aachen (Germany) in Macromolecular Chemistry. From 1999 to 2001, Joerg Lahann was a postdoctoral associate in the Chemical Engineering Department of Massachusetts Institute of Technology (USA) and he then spent one year at Harvard University and Massachusetts Institute of Technology (HMST). He joined the Chemical Engineering Department at the University of Michigan in 2003. Professor Lahann has received a number of honors and awards including Technology Review TR100 Young Innovator Award, NSF CAREER Award, the Justus-Liebig Fellowship of the Fonds of the German Industry, Sigma XI - Full Membership, German Science Foundation Postdoctoral Grant, Borchers Prize of the RWTH Aachen (given to graduate students for an outstanding performance), and the Young Student Achievement Award of the Fonds of the German Industry. His research interests are broadly related to surface engineering as well as biomedical engineering and nanotechnology.  Mimicking natural biochemical processes, click chemistry is a modular approach to organic synthesis, joining together small chemical units quickly, efficiently and predictably. In contrast to complex traditional synthesis, click reactions offer high selectivity and yields, near-perfect reliability and exceptional tolerance towards a wide range of functional groups and reaction conditions. These ‘spring loaded’ reactions are achieved by using a high thermodynamic driving force, and are attracting tremendous attention throughout the chemical community. Originally introduced with the focus on drug discovery, the concept has been successfully applied to materials science, polymer chemistry and biotechnology. \u003c\/p\u003e\u003cp\u003eThe first book to consider this topic\u003ci\u003e, Click Chemistry for Biotechnology and Materials Science\u003c\/i\u003e examines the fundamentals of click chemistry, its application to the precise design and synthesis of macromolecules, and its numerous applications in materials science and biotechnology. The book surveys the current research, discusses emerging trends and future applications, and provides an important nucleation point for research.\u003c\/p\u003e \u003cp\u003eEdited by one of the top 100 young innovators with the greatest potential to have an impact on technology in the 21st century according to Technology Review and with contributions from pioneers in the field, \u003ci\u003eClick Chemistry for Biotechnology and Materials Science\u003c\/i\u003e provides an ideal reference for anyone wanting to learn more about click reactions.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47988928119013,"sku":"NP9780470699706","price":209.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470699706.jpg?v=1761782087","url":"https:\/\/k12savings.com\/es\/products\/click-chemistry-for-biotechnology-and-materials-science-isbn-9780470699706","provider":"K12savings","version":"1.0","type":"link"}