{"product_id":"cholesterol-regulation-of-ion-channels-and-receptors-isbn-9780470874325","title":"Cholesterol Regulation of Ion Channels and Receptors","description":"\u003cp\u003e\u003cb\u003eExamines new research on the role of cholesterol in regulating ion channels and receptors and its effect on health\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eDrawing together and analyzing all the latest research findings, this book explores the role of cholesterol in the regulation of ion channels and receptors, including its pathological effects. It is the first book to comprehensively describe the complex mechanisms by which cholesterol regulates two major classes of membrane proteins. Moreover, it sheds new light on how cholesterol affects essential cellular functions such as the contraction of the heart, propagation of nerve impulses, and regulation of blood pressure and kidney function.\u003c\/p\u003e \u003cp\u003eWritten and edited by leading pioneers in the field, \u003ci\u003eCholesterol Regulation of Ion Channels and Receptors\u003c\/i\u003e is divided into three parts:\u003c\/p\u003e \u003cul\u003e \u003cli\u003ePart I, \u003ci\u003eCholesterol Regulation of Membrane Properties\u003c\/i\u003e, introduces the heterogeneity of cholesterol distribution in biological membranes and the physical and biological implications of the formation of cholesterol-rich membrane domains.\u003c\/li\u003e \u003cli\u003ePart II, \u003ci\u003eCholesterol Regulation of Ion Channels\u003c\/i\u003e, examines the mechanisms underlying cholesterol sensitivities of ion channels, including the regulation of ion channels by cholesterol as a boundary lipid.\u003c\/li\u003e \u003cli\u003ePart III, \u003ci\u003eCholesterol Regulation of Receptors\u003c\/i\u003e, explores the latest discoveries concerning how cholesterol regulates distinct types of receptors, including G-protein coupled receptors, LDL and scavenger receptors, and innate immune system receptors.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eIncreased levels of cholesterol represent a major health risk. Understanding cholesterol regulation of ion channels and receptors is essential for facilitating the development of new therapeutic strategies to alleviate the impact of pathological cholesterol conditions. With this book as their guide, readers have access to the most current knowledge in the field.\u003c\/p\u003e  \u003cp\u003eFOREWORD vii\u003c\/p\u003e \u003cp\u003ePREFACE ix\u003c\/p\u003e \u003cp\u003eCONTRIBUTORS xi\u003c\/p\u003e \u003cp\u003e\u003cb\u003eI CHOLESTEROL REGULATION OF MEMBRANE PROPERTIES 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 CHOLESTEROL TRAFFICKING AND DISTRIBUTION BETWEEN CELLULAR MEMBRANES 3\u003cbr\u003e \u003ci\u003eDaniel Wu¨ stner, Lukasz Michael Solanko, and Frederik W. Lund\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 CHOLESTEROL REGULATION OF MEMBRANE PROTEIN FUNCTION BY CHANGES IN BILAYER PHYSICAL PROPERTIES—AN ENERGETIC PERSPECTIVE 27\u003cbr\u003e \u003ci\u003eJens A. Lundbæk and Olaf S. Andersen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eII CHOLESTEROL REGULATION OF ION CHANNELS 45\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3 INSIGHTS INTO STRUCTURAL DETERMINANTS OF CHOLESTEROL SENSITIVITY OF KIR CHANNELS 47\u003cbr\u003e \u003ci\u003eAvia Rosenhouse-Dantsker and Irena Levitan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 ROLE OF LIPID RAFTS IN THE REGULATION OF STORE-OPERATED CA2+ CHANNELS 69\u003cbr\u003e \u003ci\u003eHwei L. Ong and Indu S. Ambudkar\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 CHOLESTEROL REGULATION OF CARDIAC ION CHANNELS 91\u003cbr\u003e \u003ci\u003eElise Balse, Ste´ phane Hatem, and Stanley Nattel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 DIFFERENTIAL CONTRIBUTION OF BK SUBUNITS TO NONGENOMIC REGULATION OF CHANNEL FUNCTION BY STEROIDS 109\u003cbr\u003e \u003ci\u003eAlex M. Dopico, Anna N. Bukiya, and Aditya K. Singh\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 REGULATION OF K+ CHANNELS BY CHOLESTEROL-RICH MEMBRANE DOMAINS IN THE IMMUNE SYSTEM 135\u003cbr\u003e \u003ci\u003eNu´ ria Comes and Antonio Felipe\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 INDIRECT CHANNEL REGULATION BY CHOLESTEROL: THE ROLE OF CAVEOLAE AND CAVEOLINS IN REGULATING KATP CHANNEL FUNCTION 161\u003cbr\u003e \u003ci\u003eCaroline Dart\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIII CHOLESTEROL REGULATION OF RECEPTORS 181\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9 REGULATION OF THE NICOTINIC ACETYLCHOLINE RECEPTOR BY CHOLESTEROL AS A BOUNDARY LIPID 183\u003cbr\u003e \u003ci\u003eFrancisco J. Barrantes\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 SPECIFIC AND NONSPECIFIC REGULATION OF GPCR FUNCTION BY CHOLESTEROL 205\u003cbr\u003e \u003ci\u003eGerald Gimpl and Katja Gehrig-Burger\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 STRUCTURAL INSIGHTS INTO CHOLESTEROL INTERACTIONS WITH G-PROTEIN-COUPLED RECEPTORS 231\u003cbr\u003e \u003ci\u003eJeremiah S. Joseph, Enrique E. Abola, and Vadim Cherezov\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 MEMBRANE CHOLESTEROL: IMPLICATIONS IN RECEPTOR FUNCTION 255\u003cbr\u003e \u003ci\u003eSandeep Shrivastava and Amitabha Chattopadhyay\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 THE ROLE OF CHOLESTEROL AND LIPID RAFTS IN REGULATION OF TLR RECEPTORS 273\u003cbr\u003e \u003ci\u003eRuxana T. Sadikot\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eINDEX 281\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eIRENA LEVITAN, PhD\u003c\/b\u003e, is Associate Professor of Medicine at the University of Illinois College of Medicine at Chicago. Her research interests focus on the impact of dyslipidemia on K+ channels and endothelial biomechanics.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eFRANCISCO J. BARRANTES\u003c\/b\u003e is the former head of the National Research Council (CONICET) – Bahia Blanca and UNESCO Chair of Biophysics and Molecular Neurobiology. Currently, he is Director of the Laboratory of Molecular Neurobiology and Professor at the Faculty of Medical Sciences, Pontifical Catholic University of Argentina. His current research interests focus on the understanding of nicotinic acetylcholine receptor-membrane cross-talk.\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eExamines new research on the role of cholesterol in regulating ion channels and receptors and its effect on health\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eDrawing together and analyzing all the latest research findings, this book explores the role of cholesterol in the regulation of ion channels and receptors, including its pathological effects. It is the first book to comprehensively describe the complex mechanisms by which cholesterol regulates two major classes of membrane proteins. Moreover, it sheds new light on how cholesterol affects essential cellular functions such as the contraction of the heart, propagation of nerve impulses, and regulation of blood pressure and kidney function.\u003c\/p\u003e \u003cp\u003eWritten and edited by leading pioneers in the field, \u003ci\u003eCholesterol Regulation of Ion Channels and Receptors\u003c\/i\u003e is divided into three parts:\u003c\/p\u003e \u003cul\u003e \u003cli\u003ePart I, \u003ci\u003eCholesterol Regulation of Membrane Properties\u003c\/i\u003e, introduces the heterogeneity of cholesterol distribution in biological membranes and the physical and biological implications of the formation of cholesterol-rich membrane domains.\u003c\/li\u003e \u003cli\u003ePart II, \u003ci\u003eCholesterol Regulation of Ion Channels\u003c\/i\u003e, examines the mechanisms underlying cholesterol sensitivities of ion channels, including the regulation of ion channels by cholesterol as a boundary lipid.\u003c\/li\u003e \u003cli\u003ePart III, \u003ci\u003eCholesterol Regulation of Receptors\u003c\/i\u003e, explores the latest discoveries concerning how cholesterol regulates distinct types of receptors, including G-protein coupled receptors, LDL and scavenger receptors, and innate immune system receptors.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eIncreased levels of cholesterol represent a major health risk. Understanding cholesterol regulation of ion channels and receptors is essential for facilitating the development of new therapeutic strategies to alleviate the impact of pathological cholesterol conditions. With this book as their guide, readers have access to the most current knowledge in the field.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47988918354149,"sku":"NP9780470874325","price":153.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470874325.jpg?v=1761782047","url":"https:\/\/k12savings.com\/es\/products\/cholesterol-regulation-of-ion-channels-and-receptors-isbn-9780470874325","provider":"K12savings","version":"1.0","type":"link"}