Chemical Weapons Convention Chemicals Analysis

Describes the procedures for collection of samples, sample preparation, and analysis of CWC-related chemicals. It deals with analytical procedures that can be followed in well-equipped off-site laboratories (designated laboratories), as well as the on-site analytical procedures that the OPCW inspectors use in sample collection and preliminary analysis of the samples in field conditions.

• A one-of-a-kind, highly topical handbook for every expert in the chemical weapons field
• Outlines the methods for analysing chemical weapons both on and off site
• Authored by international experts in the field from top laboratories in both government and academic institutions

List of Contributors.

Preface.

Chapter 1: Introduction (Markku Mesilaakso).

Chapter 2: Sampling and Analysis in the Chemical Weapons Convention and the OPCW Mobile Laboratory (Stefan Mogl).

Chapter 3: On-site Analysis by the Inspection Team. Sampling, Analysis, Equipment, Procedures and Strategies (Sabine Kruger).

Chapter 4: The OPCW Gas Chromatograph/Mass Spectrometer for On-site Analysis. Instrumentation, AMDIS Software and Preparations for Use (Mieczyslaw Sokolowski).

Chapter 5: Hazardous Environment Monitoring (George M. Murray and David S. Lawrence).

Chapter 6: A Comprehensive Review of the Official OPCW Proficiency Test (Jeanet Hendrikse).

Chapter 7: The OPCW Central Analytical Database (Charles Nyanyira).

Chapter 8: Analysis Strategy for Analysis of Chemicals Related to the Chemical Weapons Convention in an Off-site Laboratory (Markku Mesilaakso).

Chapter 9: Sample Preparation for Analysis of Chemicals Related to the Chemical Weapons Convention in an Off-site Laboratory (Marja-Leena Kuitunen).

Chapter 10: Gas Chromatography in Screening of Chemicals Related to the Chemical Weapons Convention (Olli Kostiainen).

Chapter 11: Gas Chromatography/MassSpectrometry in Analysis of Chemicals Related to the Chemical Weapons Convention (Eric R. J. Wils).

Chapter 12: Liquid Chromatography / Mass Spectrometry in Analysis of Chemicals Related to the Chemical Weapons Convention (R. M. Black and R. W. Read).

Chapter 13: Nuclear Magnetic Resonance Spectroscopy in Analysis of Chemicals Related to the Chemical Weapons Convention (Markku Mesilaakso and Andreas Niederhauser).

Chapter 14: Fourier Transform Infrared Spectroscopy in Analysis of Chemicals Related to the Chemical Weapons Convention (Martin T. Soderstrom).

Chapter 15: Capillary Electrophoresis in Analysis of Chemicals Related to the Chemical Weapons Convention (Jeremy E. Melanson and Camille A. Boulet).

Chapter 16: Methods for the Retrospective Detection of Exposure to Toxic Scheduled Chemicals.
Part A: Analysis of Free Metabolites (R. M. Black and D. Noort).

Chapter 17: Methods for Retrospective Detection of Exposure to Toxic Scheduled Chemicals.
Part B: Mass Spectrometric and Immunochemical Analysis of Covalent Adducts to Proteins and DNA (D. Noort and R. M. Black).

Index.

"…this book would be a significant addition to collections serving analytical and environmental chemistry research and teaching, as well as to...those interested in weapons proliferation issues." (E-STREAMS, June 2006) Markku Mesilaakso, VERIFIN, Finland. The States Parties to the Chemical Weapons Convention (CWC) have established the Organization for the Prohibition of Chemical Weapons (OPCW) in order to achieve the object and purpose of the Convention. It aims to ensure the implementation of the CWC’s provisions, including those for international verification of compliance with it, and to provide a forum for consultation and cooperation among States Parties. The aim of this book is to give a comprehensive view of how to internationally verify compliance with the CWC, in principle, using analytical chemistry and related strategies and methods.

There are currently eighteen analytical laboratories that have established capability, and obtained recognized competence in, the analysis of samples for CWC-related chemicals; these laboratories are the OPCW designated laboratories. The majority of the chapters in this book discuss the analytical methods used in these off-site laboratories. The methods discussed are for the identification of target chemicals from environmental and human origin samples. The procedures and strategies for on-site sampling and analysis are also discussed.

A variety of topics are covered, including:

• the requirements of the CWC for verification, sampling, mobile laboratories and their equipment and software;
• sample preparation from environmental samples;
• official inter-laboratory proficiency tests arranged by the OPCW;
• the OPCW Central Analytical Database (OCAD);
• monitoring of hazardous chemicals;
• analysis strategies and quality assurance;
• analytical methods including gas and liquid chromatography hyphenated with mass spectrometry or other detectors, nuclear magnetic resonance spectroscopy, infrared spectroscopy and capillary electrophoresis, and the detection of exposure to toxic scheduled chemicals.

This book is aimed at researchers from the fields of environmental and analytical chemistry, and researchers in civil and military laboratories. The National Authorities of the States Parties to the CWC will find the book useful as it covers developments in the area of CWC chemicals analysis. The approaches are practical and the chapters are particularly useful for those people responsible for developing their laboratory analysis methods and work instructions.