{"product_id":"chemical-biology-isbn-9781118101186","title":"Chemical Biology","description":"\u003cp\u003e\u003cb\u003e\u003ci\u003eAn authoritative look at the application of chemical biology in drug discovery and development\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eBased on the award-winning \u003ci\u003eWiley Encyclopedia of Chemical Biology\u003c\/i\u003e published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases.\u003c\/p\u003e \u003cp\u003eComprising carefully selected reprints from the \u003ci\u003eEncyclopedia\u003c\/i\u003e as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease. Self-contained articles cover a variety of essential topics, including:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eThe design, development, and optimization of drug candidates\u003c\/li\u003e \u003cli\u003eThe pharmacokinetics and properties of drugs\u003c\/li\u003e \u003cli\u003eDrug transport and delivery\u003c\/li\u003e \u003cli\u003eNatural products and natural product models as pharmaceuticals\u003c\/li\u003e \u003cli\u003eBiological mechanisms underlying health and disease\u003c\/li\u003e \u003cli\u003eTreatment strategies for a range of diseases, from HIV to schizophrenia\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eChemical Biology\u003c\/i\u003e is a top-notch guide and reference for anyone working in the areas of drug discovery and development, including researchers in chemical biology and other fields such as biochemistry, medicine, and pharmaceutical sciences.\u003c\/p\u003e  \u003cp\u003eContributors xi\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART I DRUG DISCOVERY AND DEVELOPMENT 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 The Role of Chemical Biology in Drug Discovery 3\u003cbr\u003e \u003ci\u003eAndrew J. Pope\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Computational Approaches to Drug Discovery and Development 23\u003cbr\u003e \u003ci\u003eHonglin Li, Mingyue Zheng, Xiaomin Luo, Weiliang Zhu, and Hualiang Jiang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Design and Selection of Small Molecule Inhibitors 41\u003cbr\u003e \u003ci\u003eJianwei Che, Yi Liu, and Nathanael S. Gray\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Lead Optimization in Drug Discovery 65\u003cbr\u003e \u003ci\u003eCraig W. Lindsley, David Weaver, Thomas M. Bridges, and J. Phillip Kennedy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Pharmacokinetics of Drug Candidates 83\u003cbr\u003e \u003ci\u003eRonald E. White\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 ADME Properties of Drugs 101\u003cbr\u003e \u003ci\u003eLi Di and Edward H. Kerns\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Drug Transport in Living Systems 115\u003cbr\u003e \u003ci\u003eYael Elbaz and Shimon Schuldiner\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Blood-Brain Barrier: Considerations in Drug Development and Delivery 133\u003cbr\u003e \u003ci\u003eDavid S. Miller and Brian T. Hawkins\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Pharmacokinetic Considerations: Methods and Systems of Controlled Drug Delivery 147\u003cbr\u003e \u003ci\u003eZhong Zuo and Vincent H. L. Lee\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Pharmaceuticals: Natural Products and Natural Product Models 165\u003cbr\u003e \u003ci\u003eSheo B. Singh\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART II CHEMICAL BIOLOGY TO UNDERSTAND AND TARGET DISEASE 203\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11 The Role of Chemical Biology in Understanding and Treating\u003cbr\u003e Disease—Are Small Molecule “Correctors” the Way of the Future? 205\u003cbr\u003e \u003ci\u003eDavid Selwood\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Anxiety Disorders 215\u003cbr\u003e \u003ci\u003eMiklos Toth\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Chronic Obstructive Pulmonary Disease (COPD) 245\u003cbr\u003e \u003ci\u003ePeter J. Barnes\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Depression 267\u003cbr\u003e \u003ci\u003eGlen B. Baker and Nicholas D. Mitchell\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Osteoarthritis 293\u003cbr\u003e \u003ci\u003eMarjolaine Gosset, Jeremie Sellam, Claire Jacques, nd Francis Berenbaum\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Human Immunodeficiency Virus (HIV) 331\u003cbr\u003e \u003ci\u003eJoseph P. Vacca\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 Allergy and Asthma 341\u003cbr\u003e \u003ci\u003eGarry M. Walsh\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 Schizophrenia 357\u003cbr\u003e \u003ci\u003eFerenc Martenyi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19 Protein Misfolding and Disease 379\u003cbr\u003e \u003ci\u003eJohanna C. Scheinost, Grant E. Boldt, and Paul Wentworth\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20 Protein Trafficking Diseases 401\u003cbr\u003e \u003ci\u003eHeidi M. Sampson and David Y. Thomas\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21 Metabolic Diseases 419\u003cbr\u003e \u003ci\u003eCynthia M. Arbeeny\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22 Mitochondrial Medicine 445\u003cbr\u003e \u003ci\u003eRichard J. T. Rodenburg and Jan A. M. Smeitink\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23 Lysosomal Disorders 461\u003cbr\u003e \u003ci\u003eDoug A. Brooks and Maria Fuller\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 483\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eNATANYA CIVJAN, PhD,\u003c\/b\u003e is a freelance editor with a doctorate in biochemistry. Formerly with John Wiley \u0026amp; Sons, she developed and edited the \u003ci\u003eWiley Encyclopedia of Chemical Biology\u003c\/i\u003e and was part of the team responsible for the \u003ci\u003eWiley Interdisciplinary Reviews,\u003c\/i\u003e which won top prizes in publishing from the American Publishers Awards for Professional and Scholarly Excellence.\u003c\/p\u003e  \u003cp\u003e\u003cb\u003e\u003ci\u003eAn authoritative look at the application of chemical biology in drug discovery and development\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eBased on the award-winning \u003ci\u003eWiley Encyclopedia of Chemical Biology\u003c\/i\u003e published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases.\u003c\/p\u003e \u003cp\u003eComprising carefully selected reprints from the \u003ci\u003eEncyclopedia\u003c\/i\u003e as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease. Self-contained articles cover a variety of essential topics, including:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eThe design, development, and optimization of drug candidates\u003c\/li\u003e \u003cli\u003eThe pharmacokinetics and properties of drugs\u003c\/li\u003e \u003cli\u003eDrug transport and delivery\u003c\/li\u003e \u003cli\u003eNatural products and natural product models as pharmaceuticals\u003c\/li\u003e \u003cli\u003eBiological mechanisms underlying health and disease\u003c\/li\u003e \u003cli\u003eTreatment strategies for a range of diseases, from HIV to schizophrenia\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eChemical Biology\u003c\/i\u003e is a top-notch guide and reference for anyone working in the areas of drug discovery and development, including researchers in chemical biology and other fields such as biochemistry, medicine, and pharmaceutical sciences.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47988904853733,"sku":"NP9781118101186","price":153.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118101186.jpg?v=1761781995","url":"https:\/\/k12savings.com\/es\/products\/chemical-biology-isbn-9781118101186","provider":"K12savings","version":"1.0","type":"link"}