Catalytic Asymmetric Radical Reactions

Strategies to develop catalytic asymmetric radical reactions, from metal-based methods to organocatalytic systems

Catalytic Asymmetric Radical Reactions systematically and comprehensively summarizes the development of different strategies to realize asymmetric radical reactions, from metal-based methods to organocatalytic systems.

The book starts with the background introduction of this topic and emphasizes the significance and challenge of the stereocontrol over the radical intermediates. Subsequently, it describes the detailed strategies to realize the asymmetric radical reactions, demonstrating how the design of chiral catalysts and substrates helps to achieve the asymmetric induction. Finally, it summarizes the developed strategies and presents a perspective in future development of asymmetric radical reactions.

Catalytic Asymmetric Radical Reactions includes information on:

• Earth-abundant transition metal (e.g., iron, cobalt, nickel, copper, and manganese)-catalyzed asymmetric radical reactions
• Photoredox/earth-abundant metal-catalyzed asymmetric radical reactions and precious transition metal-catalyzed asymmetric radical reactions
• Chiral Lewis acid-catalyzed asymmetric radical transformations and chiral-at-metal complex-catalyzed asymmetric radical reactions
• Organocatalysis via covalent bonds and hydrogen bonding for asymmetric radical transformations
• Covalent interaction (S/Sn/B-centered radical)-induced asymmetric radical reactions

Catalytic Asymmetric Radical Reactions is a timely reference for researchers in academia and industry working in the fields of organic synthesis, drug discovery, and materials science.

Preface

1. Introduction

Part I Transition metal catalysis

2. Iron catalyzed asymmetric radical reactions

3. Cobalt catalyzed asymmetric radical reactions

4. Nickel-catalyzed electrophile-nucleophile and related asymmetric radical cross-coupling

5. Nickel-catalyzed electrophile-electrophile reductive and related asymmetric radical cross-coupling

6. Copper-catalyzed cross-coupling and related asymmetric radical reactions

7. Copper-catalyzed asymmetric radical alkene difunctionalization reactions

8. Precious transition metal-catalyzed asymmetric radical reactions

Part II Lewis Acid Catalysis

9. Metal/chiral ligand-catalyzed asymmetric radical reactions

10. Lewis acid catalyzed asymmetric radical [n+2] reactions

11. Chiral metal complex-catalyzed asymmetric radical reactions

Part III Organocatalysis

12. chiral amine catalysis for asymmetric radical transformations

13. Application of chiral phosphoric acids in asymmetric radical transformations

14. Hydrogen bonding and other interactions-induced asymmetric radical transformations

Part IV Enzyme and biomimetic asymmetric radical transformation

15. Enzyme and biomimetic asymmetric radical transformation

Xin-Yuan Liu is a Chair Professor in the Department of Chemistry at Southern University of Science and Technology, China. He focuses on developing novel chiral anionic ligands in realizing the copper-catalyzed asymmetric radical reactions Currently, he is an associated editor of Synthesis. He has received numerous scientific awards, including the National Distinguished Young Scholar (NSFC), XPLORER prize, Boehringer Ingelheim Lectureship (Boston College), CAPA Distinguished Faculty Award, the Distinguished Lectureship Award from the Chemical Society of Japan, and The 12th CCS-BASF Youth Knowledge Innovation Award.

Guosheng Liu is a Professor in Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences (CAS), China. His research focuses on the highly selective functionalization of alkenes and alkanes, particularly on the site- and enantioselective sp³ C-H functionalization via metal-catalyzed radical relay. Currently, he is an associated editor of Organic Letters. He has received many scientific awards, including the National Distinguished Young Scholar (NSFC), New Cornerstone Investigator Program, Friedrich Wilhelm Bessel Research Award (Alexander von Humboldt Foundation), and The 9th CCS-BASF Youth Knowledge Innovation Award.

Strategies to develop catalytic asymmetric radical reactions, from metal-based methods to organocatalytic systems

Catalytic Asymmetric Radical Reactions systematically and comprehensively summarizes the development of different strategies to realize asymmetric radical reactions, from metal-based methods to organocatalytic systems.

The book starts with the background introduction of this topic and emphasizes the significance and challenge of the stereocontrol over the radical intermediates. Subsequently, it describes the detailed strategies to realize the asymmetric radical reactions, demonstrating how the design of chiral catalysts and substrates helps to achieve the asymmetric induction. Finally, it summarizes the developed strategies and presents a perspective in future development of asymmetric radical reactions.

Catalytic Asymmetric Radical Reactions includes information on:

• Earth-abundant transition metal (e.g., iron, cobalt, nickel, copper, and manganese)-catalyzed asymmetric radical reactions
• Photoredox/earth-abundant metal-catalyzed asymmetric radical reactions and precious transition metal-catalyzed asymmetric radical reactions
• Chiral Lewis acid-catalyzed asymmetric radical transformations and chiral-at-metal complex-catalyzed asymmetric radical reactions
• Organocatalysis via covalent bonds and hydrogen bonding for asymmetric radical transformations
• Covalent interaction (S/Sn/B-centered radical)-induced asymmetric radical reactions

Catalytic Asymmetric Radical Reactions is a timely reference for researchers in academia and industry working in the fields of organic synthesis, drug discovery, and materials science.