Bone Marrow Diagnosis

Bone Marrow Diagnosis, Third Edition, is an essential resource for pathologists and haematologists who need to report bone marrow trephine biopsies.

Practical and highly illustrated this edition has been comprehensively updated whilst remaining succinct and concentrating on the core information necessary to make an accurate diagnosis.

The text provides comparisons of the common methods of sample collection, fixation and staining, and a clear description of how to examine a trephine section. Applying a consistent approach, the chapters cover the range of disorders of bone marrow, discussing the clinical features, histopathology of bone marrow and diagnostic problems of each condition. Each chapter closes with a summary of key points and each diagnostic entity is accompanied by high quality images, over 900 in all, showing typical and more unusual examples of histological features.

This compact text, oriented at diagnosis and comprehensively accompanied by usable illustrations, is an invaluable reference tool for the trainee and practicing histopathologists, pathologists and haematologists.

• A practical guide aimed at allowing a busy pathologist to easily find the essential description and illustration of the most common bone marrow diseases seen in trephines
• Covers new treatment for chronic myeloid leukaemia, B-cell lymphoma and antibody treatments
• High quality colour images accompany each diagnostic entity
• Coverage of cytology in sections relating to myeloid dysplasias and acute leukaemias
• Addresses lymphoma categorization and individual lymphoma entities
• Incorporates new WHO classifications of lymphomas and leukaemias

Preface to the third edition vi

Preface to the first edition vii

1 Introduction 1

2 The normal bone marrow 4

3 Infections including human immunodeficiency virus 18

4 Anaemias and aplasias 32

5 The myelodysplastic syndromes 42

6 Myeloproliferative neoplasms 49

7 Acute leukaemia 69

8 Lymphomas: an overview 89

9 Precursor B and T lymphoblastic leukaemia (acute lymphoblastic leukaemia) and lymphoblastic lymphoma 101

10 Mature B cell neoplasms 108

11 Mature T and NK cell neoplasms 161

12 Hodgkin lymphoma 179

13 Metastatic disease 188

14 Bone stroma and miscellaneous changes 196

15 Technical considerations 209

Index 215

Kevin C Gatter, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, UKKevin Gatter is Professor of Pathology and Head of the Nuffield Department of Clinical Laboratory Sciences at the John Radcliffe Hospital. He has published textbooks on bone marrow diagnosis, skin lymphoma and lymphoma classification. His research interests include lymphoma diagnosis, medical informatics and angiogenesis in malignancy.
He is honorary director of the ICRF Tumour Pathology Unit and Honorary Consultant in Pathology at the John Radcliffe Hospital.

Bone Marrow Diagnosis, Third Edition, is an essential resource for pathologists and haematologists who need to report bone marrow trephine biopsies.

Practical and highly illustrated this edition has been comprehensively updated whilst remaining succinct and concentrating on the core information necessary to make an accurate diagnosis.

The text provides comparisons of the common methods of sample collection, fixation and staining, and a clear description of how to examine a trephine section. Applying a consistent approach, the chapters cover the range of disorders of bone marrow, discussing the clinical features, histopathology of bone marrow and diagnostic problems of each condition. Each chapter closes with a summary of key points and each diagnostic entity is accompanied by high quality images, over 900 in all, showing typical and more unusual examples of histological features.

This compact text, oriented at diagnosis and comprehensively accompanied by usable illustrations, is an invaluable reference tool for the trainee and practicing histopathologists, pathologists and haematologists.

• A practical guide aimed at allowing a busy pathologist to easily find the essential description and illustration of the most common bone marrow diseases seen in trephines
• Covers new treatment for chronic myeloid leukaemia, B-cell lymphoma and antibody treatments
• High quality colour images accompany each diagnostic entity
• Coverage of cytology in sections relating to myeloid dysplasias and acute leukaemias
• Addresses lymphoma categorization and individual lymphoma entities
• Incorporates new WHO classifications of lymphomas and leukaemias