{"product_id":"biomedical-mass-transport-and-chemical-reaction-isbn-9780471656326","title":"Biomedical Mass Transport and Chemical Reaction","description":"\u003cp\u003e\u003cb\u003eTeaches the fundamentals of mass transport with a unique approach emphasizing engineering principles in a biomedical environment\u003c\/b\u003e\u003c\/p\u003e \u003cul\u003e \u003cli\u003eIncludes a basic review of physiology, chemical thermodynamics, chemical kinetics, mass transport, fluid mechanics and relevant mathematical methods\u003c\/li\u003e \u003cli\u003eTeaches engineering principles and mathematical modelling useful in the broad range of problems that students will encounter in their academic programs as well as later on in their careers\u003c\/li\u003e \u003cli\u003eIllustrates principles with examples taken from physiology and medicine or with design problems involving biomedical devices\u003c\/li\u003e \u003cli\u003eStresses the simplification of problem formulations based on key geometric and functional features that permit practical analyses of biomedical applications\u003c\/li\u003e \u003cli\u003eOffers a web site of homework problems associated with each chapter and solutions available to instructors\u003c\/li\u003e \u003c\/ul\u003e Homework problems related to each chapter are available from a supplementary website (\u003chttp: these problems provide practice in basic computations model development and simulations using analytical numerical methods.\u003ePreface xvi \u003cp\u003eGuidance to Instructors xvii\u003c\/p\u003e \u003cp\u003eMethods for Solving Model Equations xix\u003c\/p\u003e \u003cp\u003eAcknowledgments xx\u003c\/p\u003e \u003cp\u003eAbout the Companion Website xxi\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart I Introduction 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Biological Structure and Function 3\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Cell Energy Related to Whole-Body Function 4\u003c\/p\u003e \u003cp\u003e1.2 Tissue and Organ Systems 8\u003c\/p\u003e \u003cp\u003e1.3 Cell Structure and Energy Metabolism 16\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Modeling Concepts for Biological Mass Transport 21\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Representation of Biological Media 21\u003c\/p\u003e \u003cp\u003e2.2 Mechanisms of Mass Transport 25\u003c\/p\u003e \u003cp\u003e2.3 Formulation of Material Balances 30\u003c\/p\u003e \u003cp\u003e2.4 Spatially Lumped and Distributed Models 32\u003c\/p\u003e \u003cp\u003eReferences 39\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II Thermodynamics of Biomedical Processes 41\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Basics of Equilibrium Thermodynamics 43\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Thermodynamic Systems and States 43\u003c\/p\u003e \u003cp\u003e3.2 Heat, Work, and the First Law 44\u003c\/p\u003e \u003cp\u003e3.3 Enthalpy and Heat Effects 45\u003c\/p\u003e \u003cp\u003e3.4 Entropy and the Second Law 46\u003c\/p\u003e \u003cp\u003e3.5 Gibbs Free Energy and Equilibrium 46\u003c\/p\u003e \u003cp\u003e3.6 Properties of the Chemical Potential 51\u003c\/p\u003e \u003cp\u003eReferences 53\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Interfacial and Membrane Equilibria 54\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Equilibrium Criterion 54\u003c\/p\u003e \u003cp\u003e4.2 Interfacial Equilibria 56\u003c\/p\u003e \u003cp\u003e4.3 Membrane Equilibria 62\u003c\/p\u003e \u003cp\u003e4.4 Electrical Double Layer 71\u003c\/p\u003e \u003cp\u003eReferences 75\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Chemical Reaction Equilibrium 76\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Equilibrium Criterion 76\u003c\/p\u003e \u003cp\u003e5.2 Equilibrium Coefficients 78\u003c\/p\u003e \u003cp\u003e5.3 Acid Dissociation 80\u003c\/p\u003e \u003cp\u003e5.4 Ligand–Receptor Binding 83\u003c\/p\u003e \u003cp\u003e5.5 Equilibrium Models of Blood Gas Content 90\u003c\/p\u003e \u003cp\u003eReferences 101\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III Fundamentals of Rate Processes 103\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Nonequilibrium Thermodynamics and Transport Rates 105\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Transport Velocities and Fluxes 105\u003c\/p\u003e \u003cp\u003e6.2 Stefan–Maxwell Equation 109\u003c\/p\u003e \u003cp\u003e6.3 Diffusion of Uncharged Substances 111\u003c\/p\u003e \u003cp\u003e6.4 Diffusion of Electrolytes 116\u003c\/p\u003e \u003cp\u003e6.5 Transport across Membranes 117\u003c\/p\u003e \u003cp\u003eReferences 123\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Mechanisms and Models of Diffusion 124\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Transport Rates in Homogeneous Materials 125\u003c\/p\u003e \u003cp\u003e7.2 Diffusion Coefficients in Gases 125\u003c\/p\u003e \u003cp\u003e7.3 Diffusion Coefficients in Liquids 128\u003c\/p\u003e \u003cp\u003e7.4 Transport in Porous Media Models of Tissue 134\u003c\/p\u003e \u003cp\u003e7.5 Transport in Suspension Models of Tissue 144\u003c\/p\u003e \u003cp\u003eReferences 151\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Chemical Reaction Rates 152\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 General Kinetic Models 152\u003c\/p\u003e \u003cp\u003e8.2 Basis of Reaction Rate Equations 154\u003c\/p\u003e \u003cp\u003e8.3 Multi-Step Reactions 158\u003c\/p\u003e \u003cp\u003e8.4 Ligand–Receptor Kinetics 161\u003c\/p\u003e \u003cp\u003e8.5 Enzyme Kinetics 166\u003c\/p\u003e \u003cp\u003e8.6 Urea Cycle as a Reaction Network 173\u003c\/p\u003e \u003cp\u003eReferences 178\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart IV Transport Models in Fluids and Membranes\u003c\/b\u003e \u003cb\u003e179\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Unidirectional Transport 181\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Unidirectional Transport Equations 181\u003c\/p\u003e \u003cp\u003e9.2 Steady-State Diffusion 186\u003c\/p\u003e \u003cp\u003e9.3 Diffusion with Parallel Convection 191\u003c\/p\u003e \u003cp\u003e9.4 Diffusion with Chemical Reaction 194\u003c\/p\u003e \u003cp\u003e9.5 Unsteady-State Diffusion 201\u003c\/p\u003e \u003cp\u003eReferences 203\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Membrane Transport I: Convection and Diffusion Processes 204\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 Ordinary Diffusion 204\u003c\/p\u003e \u003cp\u003e10.2 Diffusion with Parallel Convection 211\u003c\/p\u003e \u003cp\u003e10.3 Cell Membrane Channels 216\u003c\/p\u003e \u003cp\u003eReferences 223\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Membrane Transport II: Carrier-Mediated Processes 224\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11.1 Facilitated Transport of a Single Substance 224\u003c\/p\u003e \u003cp\u003e11.2 Cotransport of Two Substrates 227\u003c\/p\u003e \u003cp\u003e11.3 Simulation of Tracer Experiments 230\u003c\/p\u003e \u003cp\u003e11.4 Primary Active Transport 237\u003c\/p\u003e \u003cp\u003e11.5 Electrical Effects on Ion Transport 242\u003c\/p\u003e \u003cp\u003eReferences 244\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Mass Transfer Coefficients and Chemical Separation Devices 245\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e12.1 Transport Through a Single Phase 245\u003c\/p\u003e \u003cp\u003e12.2 Transport Through Multiple Phases 256\u003c\/p\u003e \u003cp\u003e12.3 Design and Performance of Separation Devices 265\u003c\/p\u003e \u003cp\u003eReferences 279\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart V Multidimensional Processes of Molecules and Cells 281\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Fluid Mechanics I: Basic Concepts 283\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e13.2 Mechanical Properties and Rheology of Fluids 289\u003c\/p\u003e \u003cp\u003e13.3 Model Formulation and Scaling of Fluid Flow 293\u003c\/p\u003e \u003cp\u003e13.4 Steady Flow Through A Tube 299\u003c\/p\u003e \u003cp\u003eReferences 306\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Fluid Mechanics II: Complex Flows 307\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e14.1 Boundary Layer Flows 307\u003c\/p\u003e \u003cp\u003e14.2 Creeping Flow Through a Leaky Tube 319\u003c\/p\u003e \u003cp\u003e14.3 Periodic Flow Along a Tube 323\u003c\/p\u003e \u003cp\u003eReference 329\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Mass Transport I: Basic Concepts and Nonreacting Systems 330\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e15.1 Three-Dimensional Mass Balances 330\u003c\/p\u003e \u003cp\u003e15.2 Special Cases 332\u003c\/p\u003e \u003cp\u003e15.3 One-Dimensional Transport Equations 334\u003c\/p\u003e \u003cp\u003e15.4 Model Formulation and Scaling of Mass Transport 339\u003c\/p\u003e \u003cp\u003e15.5 Diffusion and Convection in Nonreacting Systems 344\u003c\/p\u003e \u003cp\u003eReferences 357\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 Mass Transport II: Chemical Reacting Systems 358\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e16.1 Single-Phase Processes 358\u003c\/p\u003e \u003cp\u003e16.2 Multiphase Processes 368\u003c\/p\u003e \u003cp\u003e16.3 Processes with Interfacial Reaction 380\u003c\/p\u003e \u003cp\u003eReferences 387\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 Cell Population Dynamics 388\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e17.1 Cell Number Balances 388\u003c\/p\u003e \u003cp\u003e17.2 Cell Transport and Fate Processes 389\u003c\/p\u003e \u003cp\u003e17.3 Single Cell Population Dynamics 394\u003c\/p\u003e \u003cp\u003e17.4 Multiple Cell Population Dynamics 399\u003c\/p\u003e \u003cp\u003eReference 409\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart VI Compartmental Modeling 411\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18 Compartment Models I: Basic Concepts and Tracer Analysis 413\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e18.1 Compartmental Modeling Concepts 413\u003c\/p\u003e \u003cp\u003e18.2 Multiple-Compartment Models 421\u003c\/p\u003e \u003cp\u003e18.3 Nonideal Inputs and Moment Analysis 430\u003c\/p\u003e \u003cp\u003eReference 438\u003c\/p\u003e \u003cp\u003e\u003cb\u003e19 Compartment Models II: Analysis of Physiological Systems 439\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e19.1 Open-Loop Models 439\u003c\/p\u003e \u003cp\u003e19.1.1 Multipool Model of Glucose Metabolism 439\u003c\/p\u003e \u003cp\u003e19.2 Models with Feedback and Recirculation 452\u003c\/p\u003e \u003cp\u003eReferences 466\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart VII Advanced Biomedical Applications 467\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e20 Therapies for Tissue and Organ Dysfunction 469\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e20.1 Dynamics of Urea Clearance in a Patient During Hemodialysis 469\u003c\/p\u003e \u003cp\u003e20.2 Hemodialyzer Performance with Varying Filtration 474\u003c\/p\u003e \u003cp\u003e20.3 Gas Exchange in an Intravascular Lung Device 480\u003c\/p\u003e \u003cp\u003e20.4 Separation of Blood Components by Apheresis 486\u003c\/p\u003e \u003cp\u003e20.5 Epidermal Regeneration in Tissue-Engineered Skin 490\u003c\/p\u003e \u003cp\u003eReferences 497\u003c\/p\u003e \u003cp\u003e\u003cb\u003e21 Drug Release, Delivery, and Distribution 498\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e21.1 Drug Release From an Agglomerated Tablet 498\u003c\/p\u003e \u003cp\u003e21.2 Drug Release From an Osmotic Pump Device 504\u003c\/p\u003e \u003cp\u003e21.3 Intestinal Drug Transport 509\u003c\/p\u003e \u003cp\u003e21.4 Drug Distribution in Ablated Tissues 515\u003c\/p\u003e \u003cp\u003e21.5 Intracranial Drug Delivery and Distribution 520\u003c\/p\u003e \u003cp\u003e21.6 Whole-Body Methotrexate Distribution 526\u003c\/p\u003e \u003cp\u003eReferences 534\u003c\/p\u003e \u003cp\u003e\u003cb\u003e22 Diagnostics and Sensing 535\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e22.1 Chemical Monitoring of Tissue by Microdialysis 535\u003c\/p\u003e \u003cp\u003e22.2 Dual-Electrode Measurement of Blood Flow and Oxygen 541\u003c\/p\u003e \u003cp\u003e22.3 Detection of Ethanol in Blood from Exhaled Gas 546\u003c\/p\u003e \u003cp\u003e22.4 Oxygen Uptake and Utilization in Exercising Muscle 552\u003c\/p\u003e \u003cp\u003e22.5 Tracer Analysis with Pet Imaging 562\u003c\/p\u003e \u003cp\u003e22.6 Cancer Cell Migration with Cell–Cell Interaction 569\u003c\/p\u003e \u003cp\u003eReferences 576\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAppendix A Units and Property Data 577\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eA.1 American National Standard for SI Units 577\u003c\/p\u003e \u003cp\u003eA.2 Definitions of Concentration 579\u003c\/p\u003e \u003cp\u003eA.3 Thermodynamic Properties 580\u003c\/p\u003e \u003cp\u003eA.4 Transport Properties 583\u003c\/p\u003e \u003cp\u003eReferences 586\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAppendix B Representing Transport Processes in Complex Systems 587\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eB.1 Vector and Tensor Operations 587\u003c\/p\u003e \u003cp\u003eB.2 Nonequilibrium Thermodynamics 592\u003c\/p\u003e \u003cp\u003eB.3 Spatially Averaged Balances for Heterogeneous Tissue 596\u003c\/p\u003e \u003cp\u003eB.4 Tables for Fluid Motion in Common Coordinate Systems 602\u003c\/p\u003e \u003cp\u003eReferences 604\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAppendix C Mathematical Methods 605\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eC.1 Dimensionless Forms and Scaling 605\u003c\/p\u003e \u003cp\u003eC.2 Inversion of Square Matrices 608\u003c\/p\u003e \u003cp\u003eC.3 Initial-value Problems 609\u003c\/p\u003e \u003cp\u003eC.4 Laplace Transforms 613\u003c\/p\u003e \u003cp\u003eC.5 Alternative Representation of a Point Source 614\u003c\/p\u003e \u003cp\u003eC.6 Similarity Transform of a Partial Differential Equation 615\u003c\/p\u003e \u003cp\u003eNomenclature 619\u003c\/p\u003e \u003cp\u003eIndex 624\u003c\/p\u003e \u003cp\u003e\u003cb\u003eJames S. Ultman, PhD,\u003c\/b\u003e is a Professor Emeritus of Chemical Engineering and Biomedical Engineering at the Pennsylvania State University.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eHarihara Baskaran, PhD,\u003c\/b\u003e is a Professor of Chemical and Biomolecular Engineering at Case Western Reserve University.\u003c\/p\u003e \u003cb\u003eGerald M. Saidel, PhD,\u003c\/b\u003e is a Professor of Biomedical Engineering at Case Western Reserve University. \u003cp\u003e\u003cb\u003eTeaches the fundamentals of mass transport and chemical reaction with a unique approach emphasizing engineering principles in a biomedical environment\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe impact of engineering on medicine and biology has grown significantly. Not only has this resulted in an impressive world-wide increase in educational biomedical engineering programs, but many traditional chemical and agricultural engineering departments have changed their names to include \"bio-\" recognizing the importance of biomedical engineering research and development to human welfare and the global economy.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eBiomedical Mass Transport and Chemical Reaction \u003c\/i\u003eis designed for students whose educational emphasis involves physicochemical aspects of biomedical systems. A major objective of this textbook is to integrate engineering principles with relevant biomedical applications at the cellular, tissue, organ, and whole-body levels.  These applications incorporate basic as well as more sophisticated and complex concepts, which are appropriate for graduate as well as advanced undergraduate engineering students.\u003c\/p\u003e \u003cp\u003eDivided into seven parts\u003ci\u003e Biomedical Mass Transport and Chemical Reaction \u003c\/i\u003efeatures:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eBasic biological and modelling concepts\u003c\/li\u003e \u003cli\u003eAn overview of the thermodynamics that relate to interfacial, membrane and chemical reaction equilibria\u003c\/li\u003e \u003cli\u003eRate equations to analyze mass diffusion and chemical reactions\u003c\/li\u003e \u003cli\u003eBasic transport models in fluids and membranes\u003c\/li\u003e \u003cli\u003eMulti-dimensional transport of molecules and cell population dynamics\u003c\/li\u003e \u003cli\u003eCompartment models and analyses\u003c\/li\u003e \u003cli\u003eDetailed models related to treatment of tissue and organ dysfunction, delivery and distribution of drugs, and interpretation of biomedical measurements\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThe approach is unique in that it is organized by engineering principles rather than by specific types of applications.  Learning is reinforced with diverse example problems of increasing complexity.  This empowers students with the self-confidence necessary to successfully tackle new problems throughout their careers.\u003c\/p\u003e\u003c\/http:\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47988839121125,"sku":"NP9780471656326","price":167.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780471656326.jpg?v=1761781726","url":"https:\/\/k12savings.com\/es\/products\/biomedical-mass-transport-and-chemical-reaction-isbn-9780471656326","provider":"K12savings","version":"1.0","type":"link"}