{"product_id":"biomarkers-isbn-9780470452240","title":"Biomarkers","description":"This book provides an introduction to the field of biomarkers, how they have been and can be used, and how different approaches can be used to identify, characterize, and monitor biomarkers. The book has chapters on topics including HIV, Cancer, Parkinson’s, vascular injury, environmental exposure. A following section discusses the technologies (diagnostics and assays) to detect biomarkers and authors have emphasized the preclinical and clinical manifestation of the injury\/disease process. \u003cp\u003ePreface xxii\u003c\/p\u003e \u003cp\u003eContributors xxv\u003c\/p\u003e \u003cp\u003e1 Biomarkers: An Evolutionary Perspective 1\u003cbr\u003e\u003ci\u003eMichael Ferguson and Vishal Vaidya\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection I: Tools for Biomarker Discovery 5\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2 Genomics 7\u003cbr\u003e\u003ci\u003eWeida Tong and Donna L. Mendrick\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Proteomics for Biomarker Discovery 25\u003cbr\u003e\u003ci\u003eTimothy D. Veenstra\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Metabolic Profiling for Biomarker Discovery 47\u003cbr\u003e\u003ci\u003eHector C. Keun\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 The Bittersweet Promise of Glycobiology 75\u003cbr\u003e\u003ci\u003ePadmaparna Chaudhuri, Rania Harfouche, and Shiladitya Sengupta\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection II: Biomarkers of Injury\/Disease 89\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6 Biomarkers of Alzheimer's and Parkinson's Disease 91 \u003cbr\u003e\u003ci\u003eWalter Maetzler and Daniela Berg\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Biomarkers of Cardiac Injury 119\u003cbr\u003e\u003ci\u003eAnthony S. McLean and Stephen J. Huang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Lung Injury Biomarkers 157\u003cbr\u003e\u003ci\u003eUrmila P. Kodavanti\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Translational Biomarkers of Acute Drug-Induced Liver Injury: The Current State, Gaps and Future Opportunities 203\u003cbr\u003e\u003ci\u003eJosef Ozer, William Reagan, Sheli Schomaker, Joe Palandra, Mike Baratta and Shashi Ramaiah\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Biomarkers of Acute Kidney Injury 237\u003cbr\u003e\u003ci\u003eFrank Dieterle and Frank Sistare\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 In Search of Biomarkers for Drug-Induced Vascular Injury 281\u003cbr\u003e\u003ci\u003eJames R. Turk\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Biomarkers of Immunotoxicity 307\u003cbr\u003e\u003ci\u003eRodney R. Dietert\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Biomarkers in Obstetric Medicine 323\u003cbr\u003e\u003ci\u003eManish Maski, Sarosh Rana and S. Ananth Karumanchi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Biomarkers in Cancer 355 \u003cbr\u003e\u003ci\u003eRoopali Roy, Christine M. Coticchia, Jiang Yang and Marsha A. Moses\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Biomarkers of HIV 381\u003cbr\u003e\u003ci\u003eLewis Kaufman and Michael J Ross\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Biomarkers of in Vitro Drug-Induced Mitochondrial Dysfunction 401\u003cbr\u003e\u003ci\u003eJames A. Dykens and Yvonne Will\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection III: Technology for Biomarker Detection 423\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e17 Immunoassay-Based Technologies for the Measurement of Biological Materials Used for Biomarkers Discovery and Translational Research 425\u003cbr\u003e\u003ci\u003eVincent Ricchiuti\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 Nanoscale Techniques for Biomarker Quantification 457\u003cbr\u003e\u003ci\u003eMadhukar Varshney, and Harold G. Craighead\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19 Immunodiagnostics with a Focus on Lateral Flow Point-of-Care Devices 495\u003cbr\u003e\u003ci\u003eRoy R. Mondesire, Glen M. Ford, Hannie F. Ford, and Stephen C. Mefferd\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection IV: Hot Topics In Biomarker Research 517\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e20 Biomarkers for Environmental Exposure 519\u003cbr\u003e\u003ci\u003eJane E. Gallagher, Elaine A. Cohen Hubal and Stephen W. Edwards\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21 Clinical Study Design in Biomarker Research 549\u003cbr\u003e\u003ci\u003eOrfeas Liangos and Bertrand L. Jaber\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22 Statistical Issues in Biomarker Research 561\u003cbr\u003e\u003ci\u003eDaniel Holder and Matthew Schipper\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23 Regulatory Perspective for Biomarker Qualification from U.S. FDA 581\u003cbr\u003e\u003ci\u003eFederico Goodsaid\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e24 The European Medicines Agency Approach 589\u003cbr\u003e\u003ci\u003eMarisa Papaluca Amati and Spiros Vamvakas\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 595\u003c\/p\u003e \"In summary, this book provides an excellent introduction and overview of discovery and application of biomarkers in medicine and drug discovery and development. The chapters are well structured, with plenty of literature references for further reading, and supplemented with links to web-based resources.\" (ChemMedChem, 2011)  \u003cp\u003e \"They cover tools for discovering biomarkers, biomarkers for injury or disease, technology for detecting biomarkers, and hot topics in biomarker research.\" (\u003ci\u003eSciTech Book News\u003c\/i\u003e, December 2010)\"This book provides an introduction to the field of biomarkers, how they have been and can be used, and how different approaches can be used to identify, characterize, and monitor biomarkers.\" (News Blaze, 1 November 2010)\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eVISHAL S. VAIDYA, P\u003csmall\u003eH\u003c\/small\u003eD,\u003c\/b\u003e is an Assistant Professor of Medicine at Harvard Medical School in the Renal Division of Brigham and Women's Hospital. He directs the Laboratory of Kidney Toxicology and Regeneration with a research emphasis on discovery and evaluation of biomarkers and biosensors for early detection of kidney injury and investigates the molecular mechanisms of kidney tissue repair. Dr. Vaidya has authored more than thirty-five original research articles and twelve chapters and reviews. He serves as a councilor for the northeast chapter of the Society of Toxicology and is an elected member of Harvard School of Public Health's Center for Environmental Health. He is the recipient of the Pathway to Independence grant by the National Institute of Environmental Health Sciences. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eJOSEPH V. BONVENTRE, MD, P\u003csmall\u003eH\u003c\/small\u003eD,\u003c\/b\u003e is the Samuel A. Levine Professor of Medicine at Harvard Medical School. He is also Chief of the Renal Division and Director of the Biomedical Engineering Division of Brigham and Women's Hospital and is President-elect of the American Society of Nephrology. He has authored more than 250 original papers and 120 chapters and reviews. His research focuses primarily on the study of kidney injury and repair and signal transduction, with special emphasis on the role of inflammation, biomarkers, and stem cells. Bonventre has received a MERIT award from the National Institute of Diabetes and Digestive and Kidney Diseases.   \u003c\/p\u003e\u003cp\u003e\u003cb\u003eThe quintessential introductory guide to the study and application of biomarkers\u003c\/b\u003e  \u003c\/p\u003e\u003cp\u003eMost commonly associated with medical diagnostics, biomarkers indicate the presence of disease as well as determine its stage of progression. However, in addition to their role in detecting illness, biomarkers have important roles to play in other important biological and biochemical functions that are directly relevant to health, including predicting a drug's toxicity or effectiveness, and providing a reliable parameter with which to measure one's exposure to hazards in the environment. \u003c\/p\u003e\u003cp\u003eA robust introduction to these versatile tools, this book covers the basic fundamentals of biomarkers with discussion of their various uses, then explores the different approaches that can be applied in identifying, characterizing, and monitoring them. A solid foundation for examining the principles, advantages, disadvantages, and applications of methods for biomarker discovery techniques, this book: \u003c\/p\u003e\u003cul\u003e \u003cli\u003eDescribes classical and novel biomarkers for different organ damage and disease states including HIV, cancer, neurodegenerative disease, kidney and vascular injury\u003c\/li\u003e \u003cli\u003eEmphasizes the preclinical and clinical manifestations of injury and disease processes and how these can be predicted and monitored with biomarkers\u003c\/li\u003e \u003cli\u003eCovers the approaches, diagnostics, and assays for detecting biomarkers\u003c\/li\u003e \u003cli\u003eProvides information on the U.S. FDA's Critical Path Initiative, which has placed a high priority on the identification and qualification of additional biomarkers\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eBiomarkers offers a wealth of material that will aid researchers in choosing the correct biomarker for a given case, teach them how to accurately analyze and interpret their results, and guide them in making informed decisions concerning diagnoses and monitoring of tissue injury. For these reasons, students and professionals from many scientific fields will find Biomarkers a valuable addition to their reference library.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47988836761829,"sku":"NP9780470452240","price":203.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470452240.jpg?v=1761781718","url":"https:\/\/k12savings.com\/es\/products\/biomarkers-isbn-9780470452240","provider":"K12savings","version":"1.0","type":"link"}