{"product_id":"biological-chemistry-of-arsenic-antimony-and-bismuth-isbn-9780470713907","title":"Biological Chemistry of Arsenic, Antimony and Bismuth","description":"Arsenic, antimony and bismuth, three related elements of group 15, are all found in trace quantities in nature and have interesting biological properties and uses. While arsenic is most well known as a poison - and indeed the contamination of groundwater by arsenic is becoming a major health problem in Asia - it also has uses for the treatment of blood cancer and has long been used in traditional chinese medicine. Antimony and bismuth compounds are used in the clinic for the treatment of parasitic and bacterial infections.  \u003cp\u003e\u003ci\u003eBiological Chemistry of Arsenic, Antimony and Bismuth\u003c\/i\u003e is an essential overview of the biological chemistry of these three elements, with contributions from an international panel of experts. Topics covered include:\u003c\/p\u003e \u003cul\u003e \u003cli\u003echemistry of As, Sb and Bi\u003c\/li\u003e \u003cli\u003ebiological chemistry of arsenic\u003c\/li\u003e \u003cli\u003ebiological chemistry of Sb and Bi\u003c\/li\u003e \u003cli\u003earsenic and antimony speciation in environmental and biological samples\u003c\/li\u003e \u003cli\u003earsenic in traditional chinese medicine\u003c\/li\u003e \u003cli\u003earsenic in aquifers\u003c\/li\u003e \u003cli\u003ebiomethylation of As, Sb and Bi\u003c\/li\u003e \u003cli\u003euptake of metalloids by cells\u003c\/li\u003e \u003cli\u003ebismuth complexes of porphyrins and their potential in medical applications\u003c\/li\u003e \u003cli\u003e\n\u003ci\u003eHelicobacter pylori\u003c\/i\u003e and bismuth\u003c\/li\u003e \u003cli\u003emetabolism of arsenic trioxide in blood of the acute promyelocytic leukemia patients\u003c\/li\u003e \u003cli\u003eanticancer properties of As, Sb and Bi\u003c\/li\u003e \u003cli\u003eradio-Bi in cancer therapy\u003c\/li\u003e \u003cli\u003egenotoxicity of As, Sb and Bi\u003c\/li\u003e \u003cli\u003emetallomics as a new technique for As, Sb and Bi\u003c\/li\u003e \u003cli\u003emetalloproteomics for As, Sb and Bi\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eBiological Chemistry of Arsenic, Antimony and Bismuth\u003c\/i\u003e conveys the essential aspects of the bioinorganic chemistry of these three elements, making this book a valuable complement to more general bioinorganic chemistry texts and more specialized topical reviews. It will find a place on the bookshelves of practitioners, researchers and students working in bioinorganic chemistry and medicinal chemistry.\u003c\/p\u003e  List of Contributors.  \u003cp\u003ePreface.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 The Chemistry of Arsenic, Antimony and Bismuth\u003c\/b\u003e (\u003ci\u003eNeil Burford, Yuen-ying Carpenter, Eamonn Conrad and Cheryl D.L. Saunders\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e1.1 Properties of the Elements.\u003c\/p\u003e \u003cp\u003e1.2 Allotropes.\u003c\/p\u003e \u003cp\u003e1.3 Bond Energies.\u003c\/p\u003e \u003cp\u003e1.4 Oxidation States.\u003c\/p\u003e \u003cp\u003e1.5 Relativistic Effects and Orbital Contraction.\u003c\/p\u003e \u003cp\u003e1.6 Structure and Bonding.\u003c\/p\u003e \u003cp\u003e1.7 Clusters and Extended Structures.\u003c\/p\u003e \u003cp\u003e1.8 Hybridization and Inversion.\u003c\/p\u003e \u003cp\u003e1.9 Coordination Chemistry.\u003c\/p\u003e \u003cp\u003e1.10 Geological Occurrence.\u003c\/p\u003e \u003cp\u003e1.11 Aqueous Chemistry and Speciation.\u003c\/p\u003e \u003cp\u003e1.12 Analytical Methods and Characterization.\u003c\/p\u003e \u003cp\u003e1.13 Conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Arsenic's Interactions with Macromolecules and its Relationship to Carcinogenesis\u003c\/b\u003e (\u003ci\u003eKirk T. Kitchin\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e2.1 Introduction.\u003c\/p\u003e \u003cp\u003e2.2 Arsenic's Interactions with DNA and Proteins.\u003c\/p\u003e \u003cp\u003e2.3 Cancer – MOA.\u003c\/p\u003e \u003cp\u003e2.4 Arsenic's Many Connections to Carcinogenesis.\u003c\/p\u003e \u003cp\u003e2.5 Sources of Information on Arsenic's Mode of Action, Biochemical Effects, Carcinogenesis in Animals and Man, Metabolism and Analytical Chemistry.\u003c\/p\u003e \u003cp\u003e2.6 Conclusion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Biological Chemistry of Antimony and Bismuth\u003c\/b\u003e (\u003ci\u003eNan Yang and Hongzhe Sun\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e3.1 Introduction.\u003c\/p\u003e \u003cp\u003e3.2 Biorelevant Coordination Chemistry of Antimony and Bismuth.\u003c\/p\u003e \u003cp\u003e3.3 Antimony and Bismuth Compounds in Medicine.\u003c\/p\u003e \u003cp\u003e3.4 Interaction with Nucleic Acids.\u003c\/p\u003e \u003cp\u003e3.5 Interaction with Amino Acids and Peptides.\u003c\/p\u003e \u003cp\u003e3.6 Interaction with Proteins and Enzymes.\u003c\/p\u003e \u003cp\u003e3.7 Conclusion and Perspectives.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Metallomics Research Related to Arsenic\u003c\/b\u003e (\u003ci\u003eHiroki Haraguchi\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e4.1 Metallomics – Integrated Biometal Science.\u003c\/p\u003e \u003cp\u003e4.2 Analytical Feasibility of ICP-AES and ICP-MS.\u003c\/p\u003e \u003cp\u003e4.3 Chemical Speciation of Trace Elements in Biological Samples.\u003c\/p\u003e \u003cp\u003e4.4 Summary.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Arsenic in Traditional Chinese Medicine\u003c\/b\u003e (\u003ci\u003eKui Wang, Siwang Yu and Tianlan Zhang\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e5.1 Arsenic Bearing Minerals and their Clinical Applications.\u003c\/p\u003e \u003cp\u003e5.2 Metabolism and Pharmacokinetics of Arsenic Bearing Minerals.\u003c\/p\u003e \u003cp\u003e5.3 Pharmacological Activities and Mechanisms of Actions of ABMs.\u003c\/p\u003e \u003cp\u003e5.4 Perspectives.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Microbial Transformations of Arsenic in Aquifers\u003c\/b\u003e (\u003ci\u003eJonathan R. Lloyd\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e6.1 An Introduction to the Microbial Cycling of Arsenic.\u003c\/p\u003e \u003cp\u003e6.2 The Biochemistry of Microbial Arsenic Transformations.\u003c\/p\u003e \u003cp\u003e6.3 Microbially Driven Mobilization of Arsenic in Aquifers: a Humanitarian Disaster.\u003c\/p\u003e \u003cp\u003e6.4 Conclusions and Future Directions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Biomethylation of Arsenic, Antimony and Bismuth\u003c\/b\u003e (\u003ci\u003eRichard O. Jenkins\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e7.1 Introduction.\u003c\/p\u003e \u003cp\u003e7.2 Biomethylation of Arsenic.\u003c\/p\u003e \u003cp\u003e7.3 Biomethylation of Antimony.\u003c\/p\u003e \u003cp\u003e7.4 Biomethylation of Bismuth.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Metalloid Transport Systems\u003c\/b\u003e (\u003ci\u003eHsueh-Liang Fu, Xuan Jiang and Barry P. Rosen\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e8.1 Introduction.\u003c\/p\u003e \u003cp\u003e8.2 Metalloid Uptake Systems.\u003c\/p\u003e \u003cp\u003e8.3 Metalloid Efflux Systems.\u003c\/p\u003e \u003cp\u003e8.4 Summary and Conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Bismuth Complexes of Porphyrins and their Potential in Medical Applications\u003c\/b\u003e (\u003ci\u003eBernard Boitrel\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e9.1 Introduction.\u003c\/p\u003e \u003cp\u003e9.2 Early Work (1969-1994).\u003c\/p\u003e \u003cp\u003e9.3 Bismuth Complexes of Unfunctionalized Porphyrins.\u003c\/p\u003e \u003cp\u003e9.4 Bismuth Complexes of Functionalized Porphyrins.\u003c\/p\u003e \u003cp\u003e9.5 Future Strategies Towards Bifunctional Chelates (BFC) – Conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Helicobacter pylori and Bismuth\u003c\/b\u003e (\u003ci\u003eAruni H.W. Mendis and Barry J. Marshall\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e10.1 Introduction.\u003c\/p\u003e \u003cp\u003e10.2 Helicobacter pylori.\u003c\/p\u003e \u003cp\u003e10.3 Bismuth as an Antimicrobial Agent.\u003c\/p\u003e \u003cp\u003e10.4 Mechanism of Action of Bismuth Citrate and CBS on H. pylori and Ulcer Healing.\u003c\/p\u003e \u003cp\u003e10.5 In Vitro Susceptibility of H. pylori and other Bacteria to Bismuth Compounds and Antibiotics.\u003c\/p\u003e \u003cp\u003e10.6 The Effect of pH on Bactericidal Activity of Bismuth Compounds.\u003c\/p\u003e \u003cp\u003e10.7 Novel Preparations of Bismuth Compounds.\u003c\/p\u003e \u003cp\u003e10.8 Novel Delivery Systems for Bismuth Compounds and Other Antibiotics.\u003c\/p\u003e \u003cp\u003e10.9 The Biochemical Targets of Bismuth.\u003c\/p\u003e \u003cp\u003e10.10 Binding of Bismuth Compounds to Plasma Proteins.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Application of Arsenic Trioxide Therapy for Patients with Leukaemia\u003c\/b\u003e (\u003ci\u003eBo Yuan, Yuta Yoshino, Toshikazu Kaise and Hiroo Toyoda\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e11.1 Introduction.\u003c\/p\u003e \u003cp\u003e11.2 Cellular and Molecular Mechanisms of ATO Actions.\u003c\/p\u003e \u003cp\u003e11.3 Pharmacokinetics of ATO in APL Patients.\u003c\/p\u003e \u003cp\u003e11.4 Potential Combination Therapies with ATO.\u003c\/p\u003e \u003cp\u003e11.5 Potential ATO Application to Other Leukaemias.\u003c\/p\u003e \u003cp\u003e11.6 Conclusion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Anticancer Activity of Molecular Compounds of Arsenic, Antimony and Bismuth\u003c\/b\u003e (\u003ci\u003eEdward R.T. Tiekink\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e12.1 Introduction.\u003c\/p\u003e \u003cp\u003e12.2 Arsenic Compounds.\u003c\/p\u003e \u003cp\u003e12.3 Antimony Compounds.\u003c\/p\u003e \u003cp\u003e12.4 Bismuth Compounds.\u003c\/p\u003e \u003cp\u003e12.5 Conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Radiobismuth for Therapy\u003c\/b\u003e (\u003ci\u003eMartin W. Brechbiel and Ekaterina Dadachova\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e13.1 Introduction.\u003c\/p\u003e \u003cp\u003e13.2 Targeting Vectors.\u003c\/p\u003e \u003cp\u003e13.3 α-Emitters versus β\u003csup\u003e-\u003c\/sup\u003e-Emitters.\u003c\/p\u003e \u003cp\u003e13.4 Radionuclides.\u003c\/p\u003e \u003cp\u003e13.5 Radiolabeling – Chemistry.\u003c\/p\u003e \u003cp\u003e13.6 Preclinical Studies.\u003c\/p\u003e \u003cp\u003e13.7 Targeted α-Therapy versus Targeted β-Therapy.\u003c\/p\u003e \u003cp\u003e13.8 Clinical Studies.\u003c\/p\u003e \u003cp\u003e13.9 Alternate Delivery Methods and Uses.\u003c\/p\u003e \u003cp\u003e13.10 Prospects and Conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Genetic Toxicology of Arsenic and Antimony\u003c\/b\u003e (\u003ci\u003eToby G. Rossman and Catherine B. Klein\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e14.1 Introduction.\u003c\/p\u003e \u003cp\u003e14.2 DNA Damage in Cells Treated with Arsenicals.\u003c\/p\u003e \u003cp\u003e14.3 Mutagenesis in Cells Treated with Arsenicals.\u003c\/p\u003e \u003cp\u003e14.4 Other Genotoxic Events in Cells Treated with Arsenicals.\u003c\/p\u003e \u003cp\u003e14.5 Effects of Arsenicals on DNA Repair.\u003c\/p\u003e \u003cp\u003e14.6 Indirect Mechanisms of Mutagenicity and Comutagenicity by Arsenicals.\u003c\/p\u003e \u003cp\u003e14.7 Mutagenesis and Transformation as Secondary Effects of Genomic Instability.\u003c\/p\u003e \u003cp\u003e14.8 Antimony.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Metalloproteomics of Arsenic, Antimony and Bismuth Based Drugs\u003c\/b\u003e (\u003ci\u003eCheuk-Nam Tsang, Ruiguang Ge and Hongzhe Sun\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e15.1 Introduction.\u003c\/p\u003e \u003cp\u003e15.2 Chemical Speciation of Arsenic Based Drugs and their Metallometabolism.\u003c\/p\u003e \u003cp\u003e15.3 Metalloproteomics and its Applications to As-, Sb- and Bi-Based Metallodrugs.\u003c\/p\u003e \u003cp\u003e15.4 Biological Regulation of Arsenic and Antimony.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003e15.5 Conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIndex.\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e\u003cstrong\u003eDr Hongzhe Sun\u003c\/strong\u003e, Department of Chemistry, The University of Hong Kong\u003cbr\u003eDr. Sun's research interests lie in the chemistry of metals in biology and medicine. He has been invited to deliver lectures in various international conferences including the prestigious \"Gordon Conference on Metals in Medicine\" and \"International Conference on Biological Inorganic Chemistry\". He has published over 80 papers in solid chemical and biochemical journals. He serves in the Editorial Advisory Board of \u003cem\u003eThe Journal of Biological Inorganic Chemistry\u003c\/em\u003e (Springer, 2007-2009) and \u003cem\u003eThe Open Medicinal Chemistry Journal\u003c\/em\u003e (Bentham Science Publisher).   Arsenic, antimony and bismuth, three related elements of group 15, are all found in trace quantities in nature and have interesting biological properties and uses. While arsenic is most well known as a poison, and indeed the contamination of groundwater by arsenic is becoming a major health problem in Asia, it also has uses for the treatment of blood cancer and has long been used in traditional Chinese medicine. Antimony and bismuth compounds are used in clinics for the treatment of parasitic and bacterial infections.  \u003c\/p\u003e\u003cp\u003e\u003ci\u003eBiological Chemistry of Arsenic, Antimony and Bismuth\u003c\/i\u003e is an essential overview of the biological chemistry of these three elements, with contributions from an international panel of experts. Topics covered include:\u003c\/p\u003e \u003cul\u003e \u003cli\u003ethe chemistry and biological chemistry of arsenic, antimony and bismuth\u003c\/li\u003e \u003cli\u003ethe interaction of arsenic with macromolecules and its relationship to carcinogenesis\u003c\/li\u003e \u003cli\u003emetallomics research related to arsenic\u003c\/li\u003e \u003cli\u003earsenic in traditional Chinese medicine\u003c\/li\u003e \u003cli\u003emicrobial transformations of arsenic in aquifers\u003c\/li\u003e \u003cli\u003ebiomethylation of arsenic, antimony and bismuth\u003c\/li\u003e \u003cli\u003emetalloid transport systems\u003c\/li\u003e \u003cli\u003ebismuth complexes of porphyrins and their potential in medical applications\u003c\/li\u003e \u003cli\u003eHelicobacter pylori and bismuth\u003c\/li\u003e \u003cli\u003eapplication of arsenic trioxide therapy for patients with leukaemia\u003c\/li\u003e \u003cli\u003eanti-cancer activity of molecular compounds of arsenic, antimony, and bismuth\u003c\/li\u003e \u003cli\u003eradiobismuth for therapy\u003c\/li\u003e \u003cli\u003egenetic toxicology of arsenic and antimony\u003c\/li\u003e \u003cli\u003emetalloproteomics of arsenic-, antimony- and bismuth-based drugs\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eBiological Chemistry of Arsenic, Antimony and Bismuth\u003c\/i\u003e conveys the essential aspects of the bioinorganic chemistry of these three elements, providing a valuable complement to more general bioinorganic chemistry texts and more specialized topical reviews. It will find a place on the bookshelves of practitioners, researchers and students working in bioinorganic chemistry, medicinal chemistry and biochemistry.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47988823458021,"sku":"NP9780470713907","price":184.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470713907.jpg?v=1761781711","url":"https:\/\/k12savings.com\/es\/products\/biological-chemistry-of-arsenic-antimony-and-bismuth-isbn-9780470713907","provider":"K12savings","version":"1.0","type":"link"}