{"product_id":"biochemistry-isbn-9781119610557","title":"Biochemistry","description":"\u003cp\u003e\u003ci\u003eBiochemistry: An Integrative Approach with Expanded Topics\u003c\/i\u003e is addressed to premed, biochemistry, and life science majors taking a \u003cb\u003etwo-semester\u003c\/b\u003e biochemistry course. This version includes all 25 chapters, offering a holistic approach to learning biochemistry.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e\u003cbr\u003eAn integrated, skill-focused approach to the study of biochemistry and metabolism\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eBiochemistry\u003c\/i\u003e integrates subjects of interest to undergraduates majoring in premed, biochemistry, life science, and beyond, while preserving a chemical perspective. Respected biochemistry educator John Tansey takes a unique approach to the subject matter, emphasizing problem solving and critical thinking over rote memorization. Key concepts such as metabolism, are introduced and then revisited and cross-referenced throughout the text to establish pattern recognition and help students commit their new knowledge to long-term memory.\u003c\/p\u003e \u003cp\u003eAs part of WileyPLUS, \u003ci\u003eBiochemistry\u003c\/i\u003e includes access to video walkthroughs of worked problems, interactive elements, and expanded end-of-chapter problems with a wide range of subject matter and difficulty. Students will have access to both qualitative and quantitative worked problems, and videos model the biochemical reasoning students will need to master. This approach helps students learn to analyze data and make critical assessments of experiments—key skills for success across scientific disciplines.\u003c\/p\u003e \u003cul\u003e \u003cli\u003eIntroduces students in scientific majors to the basics of biochemistry and metabolism\u003c\/li\u003e \u003cli\u003eIntegrates and synthesizes topics throughout the text, allowing students to learn through repetition and pattern recognition\u003c\/li\u003e \u003cli\u003eEmphasizes problem solving and reasoning skills essential to life sciences, including data analysis and research assessment\u003c\/li\u003e \u003cli\u003eProvides access to video walkthroughs of worked problems, interactive features, and additional study material through WileyPLUS\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThis volume covers DNA, RNA, gene regulation, synthetic proteins, omics, plant biochemistry, and more. With this text, students studying a range of disciplines are empowered to develop a lasting foundation in biochemistry and metabolism that will serve them as they advance through their careers.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 \u003c\/b\u003e\u003cb\u003eThe Chemical Foundations of Biochemistry 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChemistry in Context 1\u003c\/p\u003e \u003cp\u003e1.1 General Chemical Principles 2\u003c\/p\u003e \u003cp\u003e1.2 Fundamental Concepts of Organic Chemistry 11\u003c\/p\u003e \u003cp\u003e1.3 The Chemistry of Water 15\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 \u003c\/b\u003e\u003cb\u003eNucleic Acids 26\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eNucleic Acids in Context 26\u003c\/p\u003e \u003cp\u003e2.1 Nucleic Acids Have Distinct Structures 27\u003c\/p\u003e \u003cp\u003e2.2 Nucleic Acids Have Many Cellular Functions 37\u003c\/p\u003e \u003cp\u003e2.3 The Manipulation of Nucleic Acids Has Transformed Biochemistry 45\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 \u003c\/b\u003e\u003cb\u003eProteins I: An Introduction to Protein Structure and Function 67\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eProteins in Context 67\u003c\/p\u003e \u003cp\u003e3.1 Amino Acid Chemistry 69\u003c\/p\u003e \u003cp\u003e3.2 Proteins Are Polymers of Amino Acids 74\u003c\/p\u003e \u003cp\u003e3.3 Proteins Are Molecules of Defined Shape and Structure 79\u003c\/p\u003e \u003cp\u003e3.4 Examples of Protein Structures and Functions 89\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 \u003c\/b\u003e\u003cb\u003eProteins II: Enzymes 101\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eEnzymes in Context 101\u003c\/p\u003e \u003cp\u003e4.1 Regarding Enzymes 103\u003c\/p\u003e \u003cp\u003e4.2 Enzymes Increase Reaction Rate 108\u003c\/p\u003e \u003cp\u003e4.3 The Mechanism of an Enzyme Can Be Deduced from Structural, Kinetic, and Spectral Data 117\u003c\/p\u003e \u003cp\u003e4.4 Examples of Enzyme Regulation 127\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 \u003c\/b\u003e\u003cb\u003eMembranes and an Introduction to Signal Transduction 138\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eBiochemistry in Context 138\u003c\/p\u003e \u003cp\u003e5.1 Membrane Structure and Function 139\u003c\/p\u003e \u003cp\u003e5.2 Signal Transduction 149\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 \u003c\/b\u003e\u003cb\u003eCarbohydrates I: Mono- and Disaccharides, Glycolysis, Gluconeogenesis, and the Fates of Pyruvate 161\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eCarbohydrates in Context 161\u003c\/p\u003e \u003cp\u003e6.1 Properties, Nomenclature, and Biological Functions of Monosaccharides 163\u003c\/p\u003e \u003cp\u003e6.2 Properties, Nomenclature, and Biological Functions of Complex Carbohydrates 170\u003c\/p\u003e \u003cp\u003e6.3 Glycolysis and an Introduction to Metabolic Pathways 177\u003c\/p\u003e \u003cp\u003e6.4 Gluconeogenesis 193\u003c\/p\u003e \u003cp\u003e6.5 The Fates of Pyruvate 196\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 \u003c\/b\u003e\u003cb\u003eThe Common Catabolic Pathway: Citric Acid Cycle, the Electron Transport Chain, and ATP Biosynthesis 209\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eElectron Transport in Context 209\u003c\/p\u003e \u003cp\u003e7.1 The Citric Acid Cycle 211\u003c\/p\u003e \u003cp\u003e7.2 The Electron Transport Chain 223\u003c\/p\u003e \u003cp\u003e7.3 ATP Biosynthesis 241\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 \u003c\/b\u003e\u003cb\u003eCarbohydrates II: Glycogen Metabolism, the Pentose Phosphate Pathway, Glycoconjugates, and Extracellular Matrices 253\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003ePolysaccharides in Context 253\u003c\/p\u003e \u003cp\u003e8.1 Glycogen Metabolism 255\u003c\/p\u003e \u003cp\u003e8.2 The Pentose Phosphate Pathway 264\u003c\/p\u003e \u003cp\u003e8.3 Carbohydrates in Glycoconjugates 273\u003c\/p\u003e \u003cp\u003e8.4 Extracellular Matrices and Biofilms 284\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 \u003c\/b\u003e\u003cb\u003eLipids I: Fatty Acids, Steroids, and Eicosanoids; Beta-Oxidation and Fatty Acid Biosynthesis 300\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eLipids in Context 300\u003c\/p\u003e \u003cp\u003e9.1 Properties, Nomenclature, and Biological Functions of Lipid Molecules 302\u003c\/p\u003e \u003cp\u003e9.2 Fatty Acid Catabolism 311\u003c\/p\u003e \u003cp\u003e9.3 Fatty Acid Biosynthesis 317\u003c\/p\u003e \u003cp\u003e9.4 Ketone Body Metabolism 329\u003c\/p\u003e \u003cp\u003e9.5 Steroid Metabolism 332\u003c\/p\u003e \u003cp\u003e9.6 Eicosanoid and Endocannabinoid Metabolism 339\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 \u003c\/b\u003e\u003cb\u003eLipids II: Metabolism and Transport of Complex Lipids 351\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eComplex Lipids in Context 351\u003c\/p\u003e \u003cp\u003e10.1 Phospholipid Metabolism 353\u003c\/p\u003e \u003cp\u003e10.2 Digestion of Triacylglycerols 361\u003c\/p\u003e \u003cp\u003e10.3 Transport of Lipids in the Circulation 367\u003c\/p\u003e \u003cp\u003e10.4 Entry of Lipids into the Cell 377\u003c\/p\u003e \u003cp\u003e10.5 Neutral Lipid Biosynthesis 380\u003c\/p\u003e \u003cp\u003e10.6 Lipid Storage Droplets, Fat Storage, and Mobilization 384\u003c\/p\u003e \u003cp\u003e10.7 Lipid Rafts as a Biochemical Entity 388\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 \u003c\/b\u003e\u003cb\u003eAmino Acid and Amine Metabolism 397\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAmine Metabolism in Context 397\u003c\/p\u003e \u003cp\u003e11.1 Digestion of Proteins 399\u003c\/p\u003e \u003cp\u003e11.2 Transamination and Oxidative Deamination 404\u003c\/p\u003e \u003cp\u003e11.3 The Urea Cycle 409\u003c\/p\u003e \u003cp\u003e11.4 Pathways of Amino Acid Carbon Skeleton Scavenging 414\u003c\/p\u003e \u003cp\u003e11.5 The Detoxification of Other Amines and Xenobiotics 423\u003c\/p\u003e \u003cp\u003e11.6 The Biochemistry of Renal Function 429\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 \u003c\/b\u003e\u003cb\u003eRegulation and Integration of Metabolism 440\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMetabolism in Context 440\u003c\/p\u003e \u003cp\u003e12.1 A Review of the Pathways and Crossroads of Metabolism 442\u003c\/p\u003e \u003cp\u003e12.2 Organ Specialization and Metabolic States 446\u003c\/p\u003e \u003cp\u003e12.3 Communication between Organs 455\u003c\/p\u003e \u003cp\u003e12.4 Metabolic Disease 463\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 \u003c\/b\u003e\u003cb\u003eNucleotide and Deoxynucleotide Metabolism 477\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eNucleotides and Deoxynucleotides in Context 477\u003c\/p\u003e \u003cp\u003e13.1 Purine Biosynthesis 478\u003c\/p\u003e \u003cp\u003e13.2 Pyrimidine Biosynthesis 484\u003c\/p\u003e \u003cp\u003e13.3 Deoxyribonucleotide Biosynthesis 489\u003c\/p\u003e \u003cp\u003e13.4 Catabolism of Nucleotides 495\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 \u003c\/b\u003e\u003cb\u003eDNA Replication, Damage, and Repair 506\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eDNA in Context 506\u003c\/p\u003e \u003cp\u003e14.1 Challenges of DNA Replication 507\u003c\/p\u003e \u003cp\u003e14.2 DNA Replication in Prokaryotes 512\u003c\/p\u003e \u003cp\u003e14.3 DNA Replication in Eukaryotes 517\u003c\/p\u003e \u003cp\u003e14.4 DNA Damage and Repair 523\u003c\/p\u003e \u003cp\u003e14.5 Homologous Recombination 534\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 \u003c\/b\u003e\u003cb\u003eRNA Synthesis and Processing 546\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eRNA Synthesis in Context 546\u003c\/p\u003e \u003cp\u003e15.1 Transcription: RNA Synthesis 548\u003c\/p\u003e \u003cp\u003e15.2 Processing of Nascent Eukaryotic RNA Messages 557\u003c\/p\u003e \u003cp\u003e15.3 RNA Export from the Nucleus 566\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 \u003c\/b\u003e\u003cb\u003eProtein Synthesis 576\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eProtein Synthesis in Context 576\u003c\/p\u003e \u003cp\u003e16.1 The Genetic Code 577\u003c\/p\u003e \u003cp\u003e16.2 RNA Structure Function in Protein Biosynthesis 580\u003c\/p\u003e \u003cp\u003e16.3 Protein Biosynthesis 585\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 \u003c\/b\u003e\u003cb\u003eControl and Regulation of Gene Expression 606\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eGene Regulation in Context 606\u003c\/p\u003e \u003cp\u003e17.1 DNA–Protein Interactions 607\u003c\/p\u003e \u003cp\u003e17.2 Regulation of Expression in Prokaryotes 613\u003c\/p\u003e \u003cp\u003e17.3 Regulation of Expression in Eukaryotes 623\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18 \u003c\/b\u003e\u003cb\u003eDetermination of Macromolecular Structure 649\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMacromolecular Structure in Context 649\u003c\/p\u003e \u003cp\u003e18.1 An Introduction to Structure Determination 650\u003c\/p\u003e \u003cp\u003e18.2 Electron Microscopy 654\u003c\/p\u003e \u003cp\u003e18.3 X-Ray Diffraction and Neutron Scattering 658\u003c\/p\u003e \u003cp\u003e18.4 Nuclear Magnetic Resonance 668\u003c\/p\u003e \u003cp\u003e\u003cb\u003e19 \u003c\/b\u003e\u003cb\u003eAllosterism and Receptor–Ligand Interactions 679\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAllosterism in Context 679\u003c\/p\u003e \u003cp\u003e19.1 Allosterism and Cooperativity 680\u003c\/p\u003e \u003cp\u003e19.2 Hemoglobin 686\u003c\/p\u003e \u003cp\u003e19.3 Receptor–Ligand Interactions 696\u003c\/p\u003e \u003cp\u003e\u003cb\u003e20 \u003c\/b\u003e\u003cb\u003eDesigner Proteins and Protein Folding 706\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eProtein Engineering and Folding in Context 706\u003c\/p\u003e \u003cp\u003e20.1 Protein Production 707\u003c\/p\u003e \u003cp\u003e20.2 Protein Engineering 714\u003c\/p\u003e \u003cp\u003e20.3 Protein Folding 724\u003c\/p\u003e \u003cp\u003e\u003cb\u003e21 \u003c\/b\u003e\u003cb\u003eBiomolecule Purification 736\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eProtein Purification in Context 736\u003c\/p\u003e \u003cp\u003e21.1 Protein Purification Basics 737\u003c\/p\u003e \u003cp\u003e21.2 Size-Exclusion Chromatography 745\u003c\/p\u003e \u003cp\u003e21.3 Affinity Chromatography 751\u003c\/p\u003e \u003cp\u003e\u003cb\u003e22 \u003c\/b\u003e\u003cb\u003eBioinformatics and Omics 764\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eBioinformatics in Context 764\u003c\/p\u003e \u003cp\u003e22.1 Introduction to Bioinformatics 765\u003c\/p\u003e \u003cp\u003e22.2 Generating Bioinformatic Data 769\u003c\/p\u003e \u003cp\u003e22.3 Analyzing Bioinformatic Data 778\u003c\/p\u003e \u003cp\u003e\u003cb\u003e23 \u003c\/b\u003e\u003cb\u003eSignal Transduction 790\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eCell Signaling in Context 790\u003c\/p\u003e \u003cp\u003e23.1 A Review of Signal Transduction 791\u003c\/p\u003e \u003cp\u003e23.2 An Overview of Regulation of Signal Transduction 797\u003c\/p\u003e \u003cp\u003e23.3 Six New Signal Transduction Pathways 800\u003c\/p\u003e \u003cp\u003e\u003cb\u003e24 \u003c\/b\u003e\u003cb\u003eProtein Trafficking 821\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eProtein Trafficking in Context 821\u003c\/p\u003e \u003cp\u003e24.1 Molecular Aspects of Protein Trafficking 822\u003c\/p\u003e \u003cp\u003e24.2 Molecular Motors 827\u003c\/p\u003e \u003cp\u003e24.3 Vesicular Fusion 834\u003c\/p\u003e \u003cp\u003e\u003cb\u003e25 \u003c\/b\u003e\u003cb\u003ePhotosynthesis and Nitrogen Fixation 841\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003ePhotosynthesis and Nitrogen Fixation in Context 841\u003c\/p\u003e \u003cp\u003e25.1 Photosynthesis 842\u003c\/p\u003e \u003cp\u003e25.2 Nitrogen Fixation 859\u003c\/p\u003e \u003cp\u003eTechniques T-1\u003c\/p\u003e \u003cp\u003esolutions A-1\u003c\/p\u003e \u003cp\u003eGlossary G-1\u003c\/p\u003e \u003cp\u003eIndex I-1\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default 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