{"product_id":"bio-glasses-isbn-9780470711613","title":"Bio-Glasses","description":"\u003cp\u003eThis new work is dedicated to glasses and their variants which can be used as biomaterials to repair diseased and damaged tissues. Bio-glasses are superior to other biomaterials in many applications, such as healing bone by signaling stem cells to become bone cells.\u003c\/p\u003e \u003cp\u003e \u003cb\u003e Key features:\u003c\/b\u003e \u003c\/p\u003e \u003cul\u003e \u003cli\u003eFirst book on biomaterials to focus on bio-glasses\u003c\/li\u003e \u003cli\u003eEdited by a leading authority on bio-glasses trained by one of its inventors, Dr Larry Hench\u003c\/li\u003e \u003cli\u003eSupported by the International Commission on Glass (ICG)\u003c\/li\u003e \u003cli\u003eAuthored by members of the ICG Biomedical Glass Committee, with the goal of creating a seamless textbook\u003c\/li\u003e \u003cli\u003eWritten in an accessible style to facilitate rapid absorption of information\u003c\/li\u003e \u003cli\u003eCovers all types of glasses, their properties and applications, and demonstrates how glass is an attractive improvement to current procedures\u003c\/li\u003e \u003cli\u003eOf interest to the biomedical as well as the materials science community.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e \u003cbr\u003e The book covers all types of glasses: traditional glasses, bioactive glasses, sol-gel glasses, phosphate glasses, glass-ceramics, composites and hybrids. Alongside discussion on how bio-glasses are made, their properties, and the reasons for their use, the authors also cover their applications in dentistry, bone regeneration and tissue engineering and cancer treatment. Its solid guidance describes the steps needed to take a new material from concept to clinic, covering the essentials of patenting, scale-up, quality assurance and FDA approval.\u003c\/p\u003e \u003cp\u003eList of Contributors xi\u003c\/p\u003e \u003cp\u003eForeword xiii\u003c\/p\u003e \u003cp\u003ePreface xvii\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 The Unique Nature of Glass 1\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eAlexis G. Clare\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 What is Glass? 1\u003c\/p\u003e \u003cp\u003e1.2 Making Glass 5\u003c\/p\u003e \u003cp\u003e1.3 Homogeneity and Phase Separation 8\u003c\/p\u003e \u003cp\u003e1.4 Forming 9\u003c\/p\u003e \u003cp\u003e1.5 Glasses that are not ‘‘Melted’’ 10\u003c\/p\u003e \u003cp\u003e1.6 Exotic Glass 11\u003c\/p\u003e \u003cp\u003e1.7 Summary 11\u003c\/p\u003e \u003cp\u003eFurther Reading 12\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Melt-Derived Bioactive Glass 13\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eMatthew D. O’Donnell\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Bioglass 13\u003c\/p\u003e \u003cp\u003e2.1.1 Introduction to Bioglass 13\u003c\/p\u003e \u003cp\u003e2.1.2 The Materials Properties of Bioglass 15\u003c\/p\u003e \u003cp\u003e2.1.3 Mechanism of Bioactivity and Effect of Glass Composition 15\u003c\/p\u003e \u003cp\u003e2.2 Network Connectivity and Bioactivity 18\u003c\/p\u003e \u003cp\u003e2.3 Alternative Bioactive Glass Compositions 19\u003c\/p\u003e \u003cp\u003e2.4 In Vitro Studies 22\u003c\/p\u003e \u003cp\u003e2.5 In Vivo Studies and Commercial Products 22\u003c\/p\u003e \u003cp\u003e2.5.1 Animal Studies 22\u003c\/p\u003e \u003cp\u003e2.5.2 Human Clinical Studies and Commercial Products 24\u003c\/p\u003e \u003cp\u003eReferences 26\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Sol-Gel Derived Glasses for Medicine 29\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eJulian R. Jones\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction 29\u003c\/p\u003e \u003cp\u003e3.2 Why Use the Sol-Gel Process? 30\u003c\/p\u003e \u003cp\u003e3.3 Sol-Gel Process Principles 31\u003c\/p\u003e \u003cp\u003e3.4 Steps in a Typical Sol-Gel Process 32\u003c\/p\u003e \u003cp\u003e3.4.1 Stage 1: Mixing 33\u003c\/p\u003e \u003cp\u003e3.4.2 Stage 2: Casting 34\u003c\/p\u003e \u003cp\u003e3.4.3 Stage 3: Gelation 34\u003c\/p\u003e \u003cp\u003e3.4.4 Stage 4: Ageing 34\u003c\/p\u003e \u003cp\u003e3.4.5 Stage 5: Drying 35\u003c\/p\u003e \u003cp\u003e3.4.6 Stage 6: Stabilisation 35\u003c\/p\u003e \u003cp\u003e3.4.7 Stage 7: Densification 35\u003c\/p\u003e \u003cp\u003e3.5 Evolution of Nanoporosity 36\u003c\/p\u003e \u003cp\u003e3.6 Making Sol-Gel Monoliths 37\u003c\/p\u003e \u003cp\u003e3.7 Making Particles 38\u003c\/p\u003e \u003cp\u003e3.8 Sol-Gel Derived Bioactive Glasses 40\u003c\/p\u003e \u003cp\u003e3.9 Summary 42\u003c\/p\u003e \u003cp\u003eReferences 43\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Phosphate Glasses 45\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eDelia S. Brauer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 45\u003c\/p\u003e \u003cp\u003e4.2 Making Phosphate Glasses 46\u003c\/p\u003e \u003cp\u003e4.3 Phosphate Glass Structure 46\u003c\/p\u003e \u003cp\u003e4.4 Temperature Behaviour and Crystallisation 50\u003c\/p\u003e \u003cp\u003e4.5 Phosphate Glass Dissolution 56\u003c\/p\u003e \u003cp\u003e4.6 Cell Compatibility of Glasses 58\u003c\/p\u003e \u003cp\u003e4.7 Phosphate Glass Fibres and Composites 60\u003c\/p\u003e \u003cp\u003e4.8 Applications 62\u003c\/p\u003e \u003cp\u003e4.9 Summary 63\u003c\/p\u003e \u003cp\u003eReferences 63\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 The Structure of Bioactive Glasses and Their Surfaces 65\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eAlastair N. Cormack\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Structure of Glasses 65\u003c\/p\u003e \u003cp\u003e5.2 Structure of Bioactive Glasses 68\u003c\/p\u003e \u003cp\u003e5.3 Computer Modeling (Theoretical Simulation) of Bioactive Glasses 69\u003c\/p\u003e \u003cp\u003e5.4 Glass Surfaces 72\u003c\/p\u003e \u003cp\u003e5.5 Summary 74\u003c\/p\u003e \u003cp\u003eReferences 74\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Bioactive Borate Glasses 75\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eSteven B. Jung\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 75\u003c\/p\u003e \u003cp\u003e6.2 What Differentiates a Bioactive Borate Glass from Other Bioactive Glasses? 76\u003c\/p\u003e \u003cp\u003e6.3 Evaluating Reactive Materials (In Vitro Versus In Vivo Testing) 79\u003c\/p\u003e \u003cp\u003e6.4 Multifunctional Bioactive Borate Glasses 81\u003c\/p\u003e \u003cp\u003e6.5 Applications of Bioactive Borate Glasses in Orthopedics and Dental Regeneration 84\u003c\/p\u003e \u003cp\u003e6.6 Soft Tissue Wound Healing 86\u003c\/p\u003e \u003cp\u003e6.7 Tissue\/Vessel Guidance 90\u003c\/p\u003e \u003cp\u003e6.8 Drug Delivery 91\u003c\/p\u003e \u003cp\u003e6.9 Commercial Product Design 92\u003c\/p\u003e \u003cp\u003e6.10 Summary 94\u003c\/p\u003e \u003cp\u003eReferences 94\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Glass-Ceramics 97\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eWolfram Höland\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Glass-Ceramics and Their Uses 97\u003c\/p\u003e \u003cp\u003e7.2 Methods Used for the Controlled Crystallization of Glasses 99\u003c\/p\u003e \u003cp\u003e7.3 A Glass-Ceramic that Hardly Expands When Heated 101\u003c\/p\u003e \u003cp\u003e7.4 High-Strength, Moldable Glass-Ceramics for Dental Restoration 102\u003c\/p\u003e \u003cp\u003e7.5 Glass-Ceramics that are Moldable and Machinable 104\u003c\/p\u003e \u003cp\u003e7.6 Outlook 104\u003c\/p\u003e \u003cp\u003eReferences 105\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Bioactive Glass and Glass-Ceramic Coatings 107\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eEnrica Verné\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 107\u003c\/p\u003e \u003cp\u003e8.2 Enameling 108\u003c\/p\u003e \u003cp\u003e8.3 Glazing 112\u003c\/p\u003e \u003cp\u003e8.4 Plasma Spraying 115\u003c\/p\u003e \u003cp\u003e8.5 Radiofrequency Magnetron Sputtering Deposition 117\u003c\/p\u003e \u003cp\u003e8.6 Pulsed Laser Deposition 117\u003c\/p\u003e \u003cp\u003e8.7 Summary 118\u003c\/p\u003e \u003cp\u003eReferences 118\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Composites Containing Bioactive Glass 121\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eAldo R. Boccaccini, Julian R. Jones, and Qi-Zhi Chen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 121\u003c\/p\u003e \u003cp\u003e9.2 Biodegradable Polymers 125\u003c\/p\u003e \u003cp\u003e9.2.1 Natural Polymers 125\u003c\/p\u003e \u003cp\u003e9.2.2 Synthetic Polymers 126\u003c\/p\u003e \u003cp\u003e9.3 Composite Scaffolds Containing Bioactive Glass 129\u003c\/p\u003e \u003cp\u003e9.4 Processing Technologies for Porous Bioactive Composites 131\u003c\/p\u003e \u003cp\u003e9.4.1 Thermally Induced Phase Separation 133\u003c\/p\u003e \u003cp\u003e9.4.2 Solid Freeform Fabrication\/Rapid Prototyping 134\u003c\/p\u003e \u003cp\u003e9.4.3 Other Processing Routes 136\u003c\/p\u003e \u003cp\u003e9.5 Case Study: the PDLLA-Bioglass Composite Scaffold System 136\u003c\/p\u003e \u003cp\u003e9.6 Final Remarks 137\u003c\/p\u003e \u003cp\u003eReferences 138\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Inorganic-Organic Sol-Gel Hybrids 139\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eYuki Shirosaki, Akiyoshi Osaka, Kanji Tsuru, and Satoshi Hayakawa\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 139\u003c\/p\u003e \u003cp\u003e10.2 Hybrids in Medicine and Why They Should Be Silica-Based 140\u003c\/p\u003e \u003cp\u003e10.3 Self-Assembled Hybrid Films and Layers of Grafted Silanes 143\u003c\/p\u003e \u003cp\u003e10.4 Sol-Gel Hybrids 144\u003c\/p\u003e \u003cp\u003e10.5 Ormosils 146\u003c\/p\u003e \u003cp\u003e10.6 Polymer Choice and Property Control in Hybrids 149\u003c\/p\u003e \u003cp\u003e10.6.1 Silica\/Gelatin 151\u003c\/p\u003e \u003cp\u003e10.7 Maintaining Bioactivity in Sol-Gel Hybrids 152\u003c\/p\u003e \u003cp\u003e10.7.1 Calcium Incorporation in Sol-Gel Hybrids 153\u003c\/p\u003e \u003cp\u003e10.7.2 Calcium-Containing Ormosils 154\u003c\/p\u003e \u003cp\u003e10.7.3 Ormotites 154\u003c\/p\u003e \u003cp\u003e10.7.4 Hybrids from Vinylsilanes or Other Bifunctional Silanes 155\u003c\/p\u003e \u003cp\u003e10.8 Summary and Outlook 156\u003c\/p\u003e \u003cp\u003eFurther Reading 156\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Dental Applications of Glasses 159\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eLeena Hupa and Antti Yli-Urpo\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction 159\u003c\/p\u003e \u003cp\u003e11.2 Structure of the Human Tooth 160\u003c\/p\u003e \u003cp\u003e11.3 Glass Bioactivity and Teeth 161\u003c\/p\u003e \u003cp\u003e11.4 Bioactive Glass in Dental Bone Regeneration 164\u003c\/p\u003e \u003cp\u003e11.5 Treatment of Hypersensitive Teeth 166\u003c\/p\u003e \u003cp\u003e11.6 Bioactive Glass Coating on Metal Implants 167\u003c\/p\u003e \u003cp\u003e11.7 Antimicrobial Properties of Bioactive Glasses 170\u003c\/p\u003e \u003cp\u003e11.8 Bioactive Glasses in Polymer Composites 171\u003c\/p\u003e \u003cp\u003e11.9 Bioactive Glasses in Glass Ionomer Cements 172\u003c\/p\u003e \u003cp\u003e11.10 Summary 173\u003c\/p\u003e \u003cp\u003eReferences 173\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Bioactive Glass as Synthetic Bone Grafts and Scaffolds for Tissue Engineering 177\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eJulian R. Jones\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 177\u003c\/p\u003e \u003cp\u003e12.2 Synthetic Bone Grafts and Regenerative Medicine 179\u003c\/p\u003e \u003cp\u003e12.3 Design Criteria for an Ideal Synthetic Bone Graft 181\u003c\/p\u003e \u003cp\u003e12.4 Bioglass and the Complication of Crystallisation During Sintering 182\u003c\/p\u003e \u003cp\u003e12.5 Making Porous Glasses 183\u003c\/p\u003e \u003cp\u003e12.5.1 Space Holder Method 183\u003c\/p\u003e \u003cp\u003e12.5.2 Polymer Foam Replication 185\u003c\/p\u003e \u003cp\u003e12.5.3 Direct Foaming 187\u003c\/p\u003e \u003cp\u003e12.5.4 Gel-Cast Foaming 187\u003c\/p\u003e \u003cp\u003e12.5.5 Sol-Gel Foaming Process 190\u003c\/p\u003e \u003cp\u003e12.5.6 Solid Freeform Fabrication 193\u003c\/p\u003e \u003cp\u003e12.5.7 Summary of Bioactive Glass Scaffold Processing 194\u003c\/p\u003e \u003cp\u003e12.6 The Future: Porous Hybrids 194\u003c\/p\u003e \u003cp\u003e12.7 Bioactive Glasses and Tissue Engineering 198\u003c\/p\u003e \u003cp\u003e12.8 Regulatory Issues 199\u003c\/p\u003e \u003cp\u003e12.9 Summary 200\u003c\/p\u003e \u003cp\u003eFurther Reading 200\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Glasses for Radiotherapy 203\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eDelbert E. Day\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction 203\u003c\/p\u003e \u003cp\u003e13.2 Glass Design and Synthesis 206\u003c\/p\u003e \u003cp\u003e13.3 Non-Degradable or Bio-inert Glasses: Rare Earth Aluminosilicate Glasses 206\u003c\/p\u003e \u003cp\u003e13.3.1 Preparation 207\u003c\/p\u003e \u003cp\u003e13.3.2 Properties 208\u003c\/p\u003e \u003cp\u003e13.4 Biodegradable Glasses: Rare Earth Borate\/ Borosilicate Glasses 209\u003c\/p\u003e \u003cp\u003e13.5 Design of Radioactive Glass Microspheres for In Vivo Applications 211\u003c\/p\u003e \u003cp\u003e13.5.1 Glass Particle Shape 211\u003c\/p\u003e \u003cp\u003e13.5.2 Useful Radioisotopes 212\u003c\/p\u003e \u003cp\u003e13.5.3 Radiation Dose 212\u003c\/p\u003e \u003cp\u003e13.5.4 Tumor Response and Tailoring of Glass Composition 213\u003c\/p\u003e \u003cp\u003e13.6 Treatment of Liver Cancer: Hepatocellular Carcinoma 215\u003c\/p\u003e \u003cp\u003e13.7 Treatment of Kidney Cancer: Renal Cell Carcinoma 220\u003c\/p\u003e \u003cp\u003e13.8 Treatment of Rheumatoid Arthritis: Radiation Synovectomy 221\u003c\/p\u003e \u003cp\u003e13.9 Summary 225\u003c\/p\u003e \u003cp\u003eReferences 226\u003c\/p\u003e \u003cp\u003eIndex 229\u003c\/p\u003e \u003cb\u003eDr Julian Jones\u003c\/b\u003e is a Senior Lecturer and Royal Academy of Engineering and EPSRC Research Fellow at Imperial College, London. He has 40 peer reviewed publications in leading journals in the field of Biomaterials and has co-edited a leading textbook. His work has been recognised by award of a prestigious Philip Leverhulme Prize in 2007, for excellence in Engineering; the Tissue and Cell Engineering Society (TCES) Early Investigator Award in 2008; and the Institute of Materials, Mining and Minerals (IOM3) Silver Medal, for outstanding achievement in Materials Science and international promotion of the subject. His work has featured in the media with articles in the Daily Mail and Daily Telegraph and an interview on Radio 5 Live. \u003cp\u003e\u003cb\u003eDr Alexis Clare\u003c\/b\u003e is Professor of Glass Science at the Inamori School of Engineering, Alfred University, NY, USA.\u003c\/p\u003e  \u003cp\u003e\"understanding the science, technology and applications of bioactive glasses is a very important educational need for the healthcare and glass community. This unique book provides the fundamental level of comprehension needed…the contents are authoritative.\"\u003cbr\u003e —\u003cb\u003eProfessor Larry L. Hench\u003c\/b\u003e, Department of Materials and Engineering at the University of Florida\u003c\/p\u003e \u003cp\u003eBio-glasses can be used to direct cells to carry out specific tasks and heal diseased and damaged tissues. They can be used in this capacity to mend bones, as drug delivery agents and in cancer therapy. This is the first book dedicated to glasses (and their variants) that can be used as biomaterials. Covering all types of glasses: traditional, sol-gel, phosphate, borate, glass ceramics, composites and hybrids, the book discusses how each are made, the reasons for their use and their properties. It then moves on to describe applications, including tissue engineering, orthopedics, dentistry, and radiotherapy.\u003c\/p\u003e \u003cp\u003eWritten in a style that is accessible to the non-expert, \u003ci\u003eBio-Glasses: An Introduction\u003c\/i\u003e explains the science and engineering principles behind glasses and their properties and provides an overview of their clinical applications.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47988812349669,"sku":"NP9780470711613","price":119.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470711613.jpg?v=1761781688","url":"https:\/\/k12savings.com\/es\/products\/bio-glasses-isbn-9780470711613","provider":"K12savings","version":"1.0","type":"link"}