{"product_id":"applications-of-toxicogenomics-in-safety-evaluation-and-risk-assessment-isbn-9780470449820","title":"Applications of Toxicogenomics in Safety Evaluation and Risk Assessment","description":"This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process – including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm.  PREFACE ix  \u003cp\u003eCONTRIBUTORS xi\u003c\/p\u003e \u003cp\u003e1 TOXICOLOGY, \"OMICS\" TECHNOLOGIES, AND TOXICOGENOMICS: A PRIMER 1\u003cbr\u003e \u003ci\u003eDarrell R. Boverhof and B. Bhaskar Gollapudi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 INTRODUCTION TO HUMAN HEALTH RISK ASSESSMENT 13\u003cbr\u003e \u003ci\u003eIrene Baskerville-Abraham, Alison Willis, Bernard Gadagbui, and Lynne T. Haber\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 PRACTICAL CONSIDERATIONS FOR THE APPLICATION OF TOXICOGENOMICS TO RISK ASSESSMENT: EARLY EXPERIENCE, CURRENT DRIVERS, AND A PATH FORWARD 41\u003cbr\u003e \u003ci\u003eDarrell R. Boverhof, David R. Geter, B. Bhaskar Gollapudi, and Heli Hollnagel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 APPROACHES AND PRACTICAL CONSIDERATIONS FOR THE ANALYSIS OF TOXICOGENOMICS DATA 65\u003cbr\u003e \u003ci\u003eZhenqiang Su, Hong Fang, Weida Tong, Huixiao Hong, Roger Perkins, and Leming Shi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 GENOMICS IN IDENTIFYING MUTAGENIC MODE OF ACTION IN CARCINOGENESIS 81\u003cbr\u003e \u003ci\u003eJiri Aubrecht and Ebru Caba\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 APPLICATION OF GENOMICS FOR PREDICTING AND UNDERSTANDING THE MODE OF ACTION FOR NONGENOTOXIC CARCINOGENS 99\u003cbr\u003e \u003ci\u003eMark R. Fielden\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 GENOMICS IN CHARACTERIZING ENDOCRINE TOXICITY 117\u003cbr\u003e \u003ci\u003eJorge M. Naciff and George P. Daston\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 STUDYING ORGAN-SPECIFIC TOXICITY USING GENE-EXPRESSION PROFILING 147\u003cbr\u003e \u003ci\u003eM. Ann Mongan and Hisham K. Hamadeh\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 TOXICOGENOMIC STUDIES IN HUMAN POPULATIONS 177\u003cbr\u003e \u003ci\u003eCliona M. McHale, Luoping Zhang, Alan E. Hubbard, and Martyn T. Smith\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 TOXICOGENOMICS APPLIED TO ECOLOGICAL RISK ASSESSMENT 207\u003cbr\u003e \u003ci\u003eDaniel L. Villeneuve, Dalma Martinovi´c, and Gerald T. Ankley\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 ANALYSIS OF TRANSCRIPTOMIC DOSE–RESPONSE DATA FOR TOXICOLOGY AND RISK ASSESSMENT 237\u003cbr\u003e \u003ci\u003eRussell S. Thomas, Longlong Yang, Harvey J. Clewell, and Melvin E. Andersen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 TOXICOGENOMICS AS A TOOL FOR VALIDATING ANIMAL TO HUMAN EXTRAPOLATIONS IN CHEMICAL RISK ASSESSMENT: CONCEPTS, APPLICATIONS, AND CHALLENGES 251\u003cbr\u003e \u003ci\u003eAlan Dombkowski and J. Craig Rowlands\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 TOXICOGENOMICS AND ANIMAL ALTERNATIVES 267\u003cbr\u003e \u003ci\u003eAnne S. Kienhuis, Joost H. M. van Delft, and Jos C. S. Kleinjans\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 TOXICOGENOMICS AND THE REGULATORY FRAMEWORK 293\u003cbr\u003e \u003ci\u003eKathryn Gallagher, Federico M. Goodsaid, David J. Dix, Susan Y. Euling, Melissa Kramer, Nancy E. McCarroll, Julian R. Preston, Philip G. Sayre, Banalata Sen, Douglas C. Wolf, and William H. Benson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 STANDARDIZATION OF GENE-EXPRESSION INFORMATION FOR THE SAFETY EVALUATION: ACTIVITIES IN JAPAN 323\u003cbr\u003e \u003ci\u003eKen-ichi Aisaki and Jun Kanno\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 APPLYING TRANSCRIPTIONAL PROFILING IN DRUG SAFETY EVALUATION 331\u003cbr\u003e \u003ci\u003eLois D. Lehman-McKeeman and William R. Foster\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 REFRAMING THE RISK ASSESSMENT PARADIGM: TOWARD A SYSTEMS BIOLOGY APPROACH 349\u003cbr\u003e \u003ci\u003eSarah N. Campion and Kim Boekelheide\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eINDEX 357\u003c\/p\u003e  \u003cb\u003eDARRELL R. BOVERHOF\u003c\/b\u003e, PhD, is a Senior Toxicology Specialist at The Dow Chemical Company where he leads research programs on respiratory allergy and sensitization, nanotoxicology, and toxicogenomics. Dr. Boverhof has authored or coauthored numerous peer-reviewed publications, review articles, and book chapters in the area of toxicogenomics and serves on the editorial board of the journal Toxicological Sciences.  \u003cp\u003e\u003cb\u003eB. BHASKAR GOLLAPUDI\u003c\/b\u003e, PhD, is the Scientific Director of Mammalian Toxicology at The Dow Chemical Company's Global Toxicology \u0026amp; Environmental Research Laboratory. Dr. Gollapudi has authored or co-authored more than 80 scientific publications. He is an Associate Editor of the journal Toxicological Sciences and is currently serving as an adjunct Associate Professor of Toxicology in the Department of Public Health at the University of Michigan.\u003c\/p\u003e  \u003cb\u003eRisk assessment and toxicogenomics — a practical review\u003c\/b\u003e  \u003cp\u003eThe past decade has seen growing interest in the use of toxicogenomics for hazard evaluation and chemical safety assessment. This book addresses the need in the field for a comprehensive, up-to-date review of this emerging technology, providing toxicologists and regulatory scientists with practical considerations to take advantage of toxicogenomics when conducting risk assessment of industrial chemicals, pharmaceuticals, agrochemicals, and consumer products.\u003c\/p\u003e \u003cp\u003eWritten by leading scientists experienced in the application of toxicogenomics data, this book includes a complete introduction to toxicogenomics and the principles of risk assessment, examines the potential of the technology to improve risk assessment practices, and offers insight into promising future trends. The emphasis throughout is on practical risk assessment, highlighting applications of toxicogenomics in the risk assessment process across diverse and important areas.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eTopics include:\u003c\/b\u003e\u003c\/p\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003eApplications in mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eThe use of toxicogenomics for enhancing mode-of-action and weight-of-evidence approaches\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eThe role of toxicogenomics in dose-response analysis, cross-species extrapolations, and animal alternatives\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eThe regulatory aspects of toxicogenomics, including chemical classification and prioritization for toxicity testing\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eStrategic approaches for the integration of toxicogenomics in safetyevaluation studies\u003c\/p\u003e \u003c\/li\u003e \u003c\/ul\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47988748878053,"sku":"NP9780470449820","price":147.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470449820.jpg?v=1761781438","url":"https:\/\/k12savings.com\/es\/products\/applications-of-toxicogenomics-in-safety-evaluation-and-risk-assessment-isbn-9780470449820","provider":"K12savings","version":"1.0","type":"link"}