{"product_id":"analytical-techniques-for-clinical-chemistry-isbn-9780470445273","title":"Analytical Techniques for Clinical Chemistry","description":"\u003cp\u003e\u003cb\u003eDiscover how analytical chemistry supports the latest clinical research\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThis book details the role played by analytical chemistry in fostering clinical research. Readers will discover how a broad range of analytical techniques support all phases of clinical research, from early stages to the implementation of practical applications. Moreover, the contributing authors' careful step-by-step guidance enables readers to better understand standardized techniques and steer clear of everyday problems that can arise in the lab.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eAnalytical Techniques for Clinical Chemistry\u003c\/i\u003e opens with an overview of the legal and regulatory framework governing clinical lab analysis. Next, it details the latest progress in instrumentation and applications in such fields as biomonitoring, diagnostics, food quality, biomarkers, pharmaceuticals, and forensics. Comprised of twenty-five chapters divided into three sections exploring Fundamentals, Selected Applications, and Future Trends, the book covers such critical topics as:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eUncertainty in clinical chemistry measurements\u003c\/li\u003e \u003cli\u003eMetal toxicology in clinical, forensic, and chemical pathology\u003c\/li\u003e \u003cli\u003eRole of analytical chemistry in the safety of drug therapy\u003c\/li\u003e \u003cli\u003eAtomic spectrometric techniques for the analysis of clinical samples\u003c\/li\u003e \u003cli\u003eBiosensors for drug analysis\u003c\/li\u003e \u003cli\u003eUse of X-ray techniques in medical research\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eEach chapter is written by one or more leading pioneers and experts in analytical chemistry. Contributions are based on a thorough review and analysis of the current literature as well as the authors' own firsthand experiences in the lab. References at the end of each chapter serve as a gateway to the literature, enabling readers to explore individual topics in greater depth.\u003c\/p\u003e \u003cp\u003ePresenting the latest achievements and challenges in the field, \u003ci\u003eAnalytical Techniques for Clinical Chemistry\u003c\/i\u003e sets the foundation for future advances in laboratory research techniques.\u003c\/p\u003e  \u003cp\u003eFOREWORD xxiii\u003c\/p\u003e \u003cp\u003ePREFACE xxv\u003c\/p\u003e \u003cp\u003eCONTRIBUTORS xxvii\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART I Exploring Fundamentals 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1. Good Clinical Practice Principles: Legal Background and Applicability 3\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eUmberto Filibeck, Angela Del Vecchio, and Fabrizio Galliccia\u003c\/i\u003e\u003cbr\u003e 1.1. Introduction 4\u003cbr\u003e 1.2. Good Clinical Practice 4\u003cbr\u003e 1.3. Good Clinical Practice: Legal Background in the European Union 8\u003cbr\u003e 1.4. Good Clinical Practice: Applicability in the European Union 10\u003cbr\u003e 1.5. Good Clinical Practice and Bioequivalence Trials: GCP Inspections and Laboratories 13\u003cbr\u003e 1.6. Good Clinical Practice for Clinical Trials with Advanced Therapy Medicinal Product 20\u003cbr\u003e 1.7. Good Clinical Practice and Clinical Trials in Developing Countries 22\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2. Clinical Chemistry and the Quest for Quality 29\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eSergio Caroli\u003c\/i\u003e\u003cbr\u003e 2.1. Introduction 30\u003cbr\u003e 2.2. Quality Today 31\u003cbr\u003e 2.3. Conclusions 55\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3. Uncertainty in Clinical Chemistry Measurements Including Preanalytical Variables 59\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eMarit Sverresdotter Sylte, Tore Wentzel-Larsen, and Bjørn J. Bolann\u003c\/i\u003e\u003cbr\u003e 3.1. Introduction 60\u003cbr\u003e 3.2. Analytical Uncertainty in Laboratory Results 62\u003cbr\u003e 3.3. Trueness and Traceability 67\u003cbr\u003e 3.4. Proficiency Testing 74\u003cbr\u003e 3.5. Biological Variations and Quality Goals 77\u003cbr\u003e 3.6. Reference Intervals 80\u003cbr\u003e 3.7. Estimating Preanalytical Uncertainty 83\u003cbr\u003e 3.8. Conclusions 92\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4. The Role and Significance of Reference Values in the Identification and Evaluation of Trace Elements from Diet 97\u003c\/b\u003e\u003cbr\u003e \u003ci\u003ePietro Apostoli and Maria Cristina Ricossa\u003c\/i\u003e\u003cbr\u003e 4.1. Reference Values 97\u003cbr\u003e 4.2. Reference Values in Specific Groups of Population: The Children Case 100\u003cbr\u003e 4.3. Trace Elements and Diet 106\u003cbr\u003e 4.4. Arsenic 108\u003cbr\u003e 4.5. Mercury 110\u003cbr\u003e 4.6. Lead 112\u003cbr\u003e 4.7. Chromium 114\u003cbr\u003e 4.8. Cadmium 115\u003cbr\u003e 4.9. Conclusions 116\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5. Sample Collection, Storage, and Pretreatment in Clinical Chemistry 127\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eAndrew Taylor\u003c\/i\u003e\u003cbr\u003e 5.1. Introduction 128\u003cbr\u003e 5.2. Collection Procedures 129\u003cbr\u003e 5.3. Storage 132\u003cbr\u003e 5.4. Pretreatment 133\u003cbr\u003e 5.5. Conclusions 136\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6. Metal Toxicology in Clinical, Forensic, and Chemical Pathology 139\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eJose A. Centeno, Todor I. Todorov, Gijsbert B. van der Voet, and Florabel G. Mullick\u003c\/i\u003e\u003cbr\u003e 6.1. Introduction 140\u003cbr\u003e 6.2. Biological Markers 140\u003cbr\u003e 6.3. Methodology for Trace Metal Ion Analysis in Clinical, Forensic, and Chemical Pathology 141\u003cbr\u003e 6.4. Case Studies of Relevance to Research and Diagnosis on Clinical Chemistry, Forensic Toxicology, and Chemical Pathology 144\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART II Selected Applications 157\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7. Elemental Speciation in Clinical Sciences 159\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eDouglas M. Templeton\u003c\/i\u003e\u003cbr\u003e 7.1. Introduction 159\u003cbr\u003e 7.2. Selected Elements 167\u003cbr\u003e 7.3. Conclusions 172\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8. The Role of Analytical Chemistry in the Safety of Drug Therapy 179\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eSandor Gorog\u003c\/i\u003e\u003cbr\u003e 8.1. Drug Quality and Analysis: Their Role in Drug Safety 180\u003cbr\u003e 8.2. Methodological Aspects 189\u003cbr\u003e 8.3. The Role of Analytical Chemistry in Drug Research, Development, and Production 200\u003cbr\u003e 8.4. Future Trends 227\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9. Analytical Techniques and Quality Control of Pharmaceuticals 245\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eFedele Manna, Francesca Rossi, and Rossella Fioravanti\u003c\/i\u003e\u003cbr\u003e 9.1. Introduction 245\u003cbr\u003e 9.2. Sources of Impurities in Medicines 246\u003cbr\u003e 9.3. Validation of Analytical Methods 247\u003cbr\u003e 9.4. Analytical Approaches 250\u003cbr\u003e 9.5. Conclusions 253\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10. Detection of Drugs in Biological Fluids for Antidoping Control 257\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eSabina Strano Rossi and Marcello Chiarotti\u003c\/i\u003e\u003cbr\u003e 10.1. Introduction 257\u003cbr\u003e 10.2. Doping Control and Analytical Requirements 258\u003cbr\u003e 10.3. Confirmation Techniques 262\u003cbr\u003e 10.4. Conclusions 264\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11. The Applicability of Plasma-Based Techniques to Biological Monitoring 269\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eIlse Steffan and Goran Vujicic\u003c\/i\u003e\u003cbr\u003e 11.1. Introduction 269\u003cbr\u003e 11.2. ICP as a Spectrochemical Source 271\u003cbr\u003e 11.3. Element Analysis in Environmental and Biological Materials 276\u003cbr\u003e 11.4. Conclusions 292\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12. Atomic Spectrometric Techniques for the Analysis of Clinical Samples 319\u003c\/b\u003e\u003cbr\u003e \u003ci\u003ePilar Bermejo Barrera, Antonio Moreda Pineiro, and Marya del Carmen Barciela Alonso\u003c\/i\u003e\u003cbr\u003e 12.1. Introduction 320\u003cbr\u003e 12.2. Analytical Techniques 320\u003cbr\u003e 12.3. Sample Preparation 347\u003cbr\u003e 12.4. Speciation Analysis 351\u003cbr\u003e 12.5. Quality Control in Trace Element Determination 355\u003cbr\u003e 12.6. Conclusions 358\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13. Applications of ICP-MS in Human Biomonitoring Studies 367\u003c\/b\u003e\u003cbr\u003e \u003ci\u003ePeter Heitland and Helmut D. Koster\u003c\/i\u003e\u003cbr\u003e 13.1. Introduction 367\u003cbr\u003e 13.2. Advantages and Limitations of Inductively Coupled Plasma Mass Spectrometry 368\u003cbr\u003e 13.3. Sample Collection and Storage 370\u003cbr\u003e 13.4. Sample Preparation 371\u003cbr\u003e 13.5. Human Biomonitoring by Inductively Coupled Plasma Mass Spectrometry 374\u003cbr\u003e 13.6. Trace Element Speciation and Metallomics 382\u003cbr\u003e 13.7. Determination of Stable Isotopes 384\u003cbr\u003e 13.8. Method Validation and Quality Assurance 384\u003cbr\u003e 13.9. Conclusions 387\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14. Molybdenum in Biological Samples and Clinical Significance of Serum Molybdenum 397\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eMunehiro Yoshida\u003c\/i\u003e\u003cbr\u003e 14.1. Introduction 397\u003cbr\u003e 14.2. Analysis of Molybdenum in Biological Samples by Inductively Coupled Plasma Mass Spectrometry 398\u003cbr\u003e 14.3. Molybdenum in Food 400\u003cbr\u003e 14.4. Molybdenum in Human Samples 401\u003cbr\u003e 14.5. Clinical Significance of Serum and Plasma Mo 404\u003cbr\u003e 14.6. Conclusions 406\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15. Application of Organometallic Speciation in Clinical Studies 409\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eBin He, Chungang Yuan, Jing Sun, and Guibin Jiang\u003c\/i\u003e\u003cbr\u003e 15.1. Introduction 409\u003cbr\u003e 15.2. Arsenic 410\u003cbr\u003e 15.3. Mercury 422\u003cbr\u003e 15.4. Tin 432\u003cbr\u003e 15.5. Conclusions 441\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16. Biosensors for Drug Analysis 455\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eDaniela Deriu and Franco Mazzei\u003c\/i\u003e\u003cbr\u003e 16.1. Introduction 455\u003cbr\u003e 16.2. Basic Concepts 456\u003cbr\u003e 16.3. Electrochemical Biosensors 460\u003cbr\u003e 16.4. Surface Plasmon Resonance 462\u003cbr\u003e 16.5. Biosensors for Drugs Analysis 465\u003cbr\u003e 16.6. Conclusions 471\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17. Bioimaging of Metals and Proteomic Studies of Clinical Samples by Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS) 479\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eJ. Sabine Becker and J. Susanne Becker\u003c\/i\u003e\u003cbr\u003e 17.1. Introduction 480\u003cbr\u003e 17.2. Analytical Approaches 481\u003cbr\u003e 17.3. Experimental Aspects of Imaging Laser Ablation Inductively Coupled Plasma Mass Spectrometry 485\u003cbr\u003e 17.4. Conclusions 498\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18. Applications of LC-MS\/MS in Clinical Laboratory Diagnostics 507\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eUta Ceglarek, Georg Martin Fiedler, and Joachim Thiery\u003c\/i\u003e\u003cbr\u003e 18.1. Introduction 507\u003cbr\u003e 18.2. Current Applications and Future Perspectives 513\u003cbr\u003e 18.3. Liquid Chromatography-Tandem Mass Spectrometry Applications in Clinical Laboratories 520\u003cbr\u003e 18.4. Conclusions 528\u003c\/p\u003e \u003cp\u003e\u003cb\u003e19. Metabolomics Using UPLC\/HPLC-Tandem Mass Spectrometry in Diagnosis and Research of Inherited Metabolic Diseases 535\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eWillem Kulik and Andre B. P. van Kuilenburg\u003c\/i\u003e\u003cbr\u003e 19.1. Introduction 536\u003cbr\u003e 19.2. Acylcarnitines 537\u003cbr\u003e 19.3. Acyl-Coenzyme A Thioesters 538\u003cbr\u003e 19.4. Amino Acids 540\u003cbr\u003e 19.5. Organic Acids 542\u003cbr\u003e 19.6. Purines and Pyrimidines 542\u003cbr\u003e 19.7. Bile Acids 544\u003cbr\u003e 19.8. Lipidomics 545\u003cbr\u003e 19.9. Carbohydrates 548\u003cbr\u003e 19.10. Neurotransmitters 548\u003cbr\u003e 19.11. Conclusions 549\u003c\/p\u003e \u003cp\u003e\u003cb\u003e20. Biomarkers of Oxidative Stress in Plasma and Urine 555\u003c\/b\u003e\u003cbr\u003e \u003ci\u003ePapasani V. Subbaiah\u003c\/i\u003e\u003cbr\u003e 20.1. Introduction 556\u003cbr\u003e 20.2. Antioxidant Mechanisms and Assays 558\u003cbr\u003e 20.3. Concluding Remarks and Perspectives 583\u003c\/p\u003e \u003cp\u003e\u003cb\u003e21. The Use of X-Ray Techniques in Medical Research 595\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eImre Szaloki, Gyula Zaray, and Norbert Szoboszlai\u003c\/i\u003e\u003cbr\u003e 21.1. Introduction 595\u003cbr\u003e 21.2. Physical Basis of XRF Analytical Methods 596\u003cbr\u003e 21.3. Basic Equipment and Setup for X-Ray Fluorescence Analysis 597\u003cbr\u003e 21.4. Quantification Approaches 606\u003cbr\u003e 21.5. Sample Preparation Techniques 609\u003cbr\u003e 21.6. Applications 610\u003cbr\u003e 21.7. Conclusions 617\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART III Future Trends 625\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e22. A New Tool Based on the Use of Stable Isotopes and Isotope Pattern Deconvolution (IPD)-ICP-MS for Nutritional and Clinical Studies 627\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eHector Gonzalez Iglesias, Maria Luisa Fernandez-Sanchez, and Alfredo Sanz-Medel\u003c\/i\u003e\u003cbr\u003e 22.1. Introduction 627\u003cbr\u003e 22.2. Milk as Source of Trace Elements 628\u003cbr\u003e 22.3. Stable Isotopes and Trace Elements Metabolism 629\u003cbr\u003e 22.4. Isotope Pattern Deconvolution 631\u003cbr\u003e 22.5. Selenium Metabolism in Lactating Rats by Means of Stable Isotopes and Isotope Pattern Deconvolution 631\u003cbr\u003e 22.6. Determination of Selenium in Urine, Faeces, Serum, and Erythrocytes by Isotope Pattern Deconvolution Inductively Coupled Plasma Mass Spectrometry 634\u003cbr\u003e 22.7. Quantitative Speciation of Selenium in Urine, Serum, and Erythrocytes by High Performance Isotope Pattern Deconvolution Inductively Coupled Plasma Mass Spectrometry 637\u003cbr\u003e 22.8. An Application of Isotope Pattern Deconvolution to Clinical Studies 643\u003cbr\u003e 22.9. Conclusions 645\u003c\/p\u003e \u003cp\u003e\u003cb\u003e23. Breath Analysis: Analytical Methodologies and Clinical Applications 651\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eAlessio Ceccarini, Fabio Di Francesco, Roger Fuoco, Silvia Ghimenti, Massimo Onor, Sara Tabucchi, and Maria Giovanna Trivella\u003c\/i\u003e\u003cbr\u003e 23.1. Introduction 652\u003cbr\u003e 23.2. Sampling Methods 655\u003cbr\u003e 23.3. Analytical Techniques 658\u003cbr\u003e 23.4. Application of Breath Analysis 664\u003cbr\u003e 23.5. Exposure Assessment 675\u003cbr\u003e 23.6. Exhaled Breath Condensate 677\u003cbr\u003e 23.7. Conclusions 677\u003c\/p\u003e \u003cp\u003e\u003cb\u003e24. Proteo-Metabolomic Strategies in the Future of Drug Development 691\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eUwe Christians, Volker Schmitz, Jost Klawitter, and Jelena Klawitter\u003c\/i\u003e\u003cbr\u003e 24.1. Introduction 692\u003cbr\u003e 24.2. The Principles of Molecular Marker Development 699\u003cbr\u003e 24.3. Technologies for Molecular Marker Development 718\u003cbr\u003e 24.4. Molecular Markers in Drug Development and Clinical Monitoring 737\u003cbr\u003e 24.5. Current Challenges 749\u003c\/p\u003e \u003cp\u003e\u003cb\u003e25. Basics in Laboratory Medicine: Past, Present, and Future 775\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eLorand A. Debreczeni, Anna Kovacsay, and Sandor Nagy\u003c\/i\u003e\u003cbr\u003e 25.1. Introduction 776\u003cbr\u003e 25.2. Informatics 777\u003cbr\u003e 25.3. Global Standardization 778\u003cbr\u003e 25.4. Focus on the Individual 782\u003cbr\u003e 25.5. A Look into the Future 783\u003c\/p\u003e \u003cp\u003eReferences 784\u003c\/p\u003e \u003cp\u003eINDEX 787\u003c\/p\u003e  \u003cp\u003e“This book is unique in its composition, as it focuses mainly on the analysis of heavy metals and trace elements but also includes some chapters that describe different aspects of the analysis of biological fluids and some other chapters on the analysis of pharmaceutical products. Based on the title of the book, it can be compared with other books that describe analytical techniques in clinical chemistry or clinical biochemistry.”  (\u003ci\u003eAnal Bioanal Chem\u003c\/i\u003e, 29 December 2013)\u003c\/p\u003e \u003cp\u003e“The book is certainly worth buying for a laboratory or institution library, and individual chapters might be a useful background reading for specific topics that are covered in an analytical or clinical university course.”  (\u003ci\u003eAccreditation and Quality Assurance\u003c\/i\u003e, 1 October 2013)\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e  \u003cp\u003e\u003cb\u003eSERGIO CAROLI, PhD,\u003c\/b\u003e was a research director in the Department of Food and Animal Safety, National Institute of Health in Rome, and Honorary Professor at Eötvös Loránd University. He is the author of approximately 400 papers and editor or coauthor of six books, including \u003ci\u003eThe Determination of Chemical Elements in Food: Applications for Atomic and Mass Spectrometry\u003c\/i\u003e (Wiley).\u003c\/p\u003e \u003cp\u003e\u003cb\u003eGYULA ZÁRAY, PhD, DSc,\u003c\/b\u003e is a Professor of Analytical Chemistry and the Director of the Cooperative Research Centre for Environmental Sciences at Eötvös Loránd University in Budapest. He has written more than 180 peer-reviewed publications and is the editor or coauthor of three books.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eDiscover how analytical chemistry supports the latest clinical research\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThis book details the role played by analytical chemistry in fostering clinical research. Readers will discover how a broad range of analytical techniques support all phases of clinical research, from early stages to the implementation of practical applications. Moreover, the contributing authors' careful step-by-step guidance enables readers to better understand standardized techniques and steer clear of everyday problems that can arise in the lab.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eAnalytical Techniques for Clinical Chemistry\u003c\/i\u003e opens with an overview of the legal and regulatory framework governing clinical lab analysis. Next, it details the latest progress in instrumentation and applications in such fields as biomonitoring, diagnostics, food quality, biomarkers, pharmaceuticals, and forensics. Comprised of twenty-five chapters divided into three sections exploring Fundamentals, Selected Applications, and Future Trends, the book covers such critical topics as:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eUncertainty in clinical chemistry measurements\u003c\/li\u003e \u003cli\u003eMetal toxicology in clinical, forensic, and chemical pathology\u003c\/li\u003e \u003cli\u003eRole of analytical chemistry in the safety of drug therapy\u003c\/li\u003e \u003cli\u003eAtomic spectrometric techniques for the analysis of clinical samples\u003c\/li\u003e \u003cli\u003eBiosensors for drug analysis\u003c\/li\u003e \u003cli\u003eUse of X-ray techniques in medical research\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eEach chapter is written by one or more leading pioneers and experts in analytical chemistry. Contributions are based on a thorough review and analysis of the current literature as well as the authors' own firsthand experiences in the lab. References at the end of each chapter serve as a gateway to the literature, enabling readers to explore individual topics in greater depth.\u003c\/p\u003e \u003cp\u003ePresenting the latest achievements and challenges in the field, \u003ci\u003eAnalytical Techniques for Clinical Chemistry\u003c\/i\u003e sets the foundation for future advances in laboratory research techniques.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47988735901925,"sku":"NP9780470445273","price":237.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470445273.jpg?v=1761781386","url":"https:\/\/k12savings.com\/es\/products\/analytical-techniques-for-clinical-chemistry-isbn-9780470445273","provider":"K12savings","version":"1.0","type":"link"}