{"product_id":"ageing-vulnerability-isbn-9780471494386","title":"Ageing Vulnerability","description":"With the ever-increasing rise in life expectancy, there is an urgent need to improve our understanding of the relationship between ageing and the pathogenesis of age-related diseases in order to identify more effective means of prevention, amelioration and management of such diseases. In addition, there is a need to reduce the social and economic impact of the ageing population. Age-related morbidity and mortality vary dramatically among individuals; this book focusses on individual differences in susceptibility to age-related disorders. \u003cp\u003eIt contains contributions from leading experts in the field on topics such as:\u003cbr\u003eage-related pathology in the brain, age-related processes in stem cells, and age-related effects on the immune system and in bone, muscle and cardiovascular tissue.\u003c\/p\u003e \u003cp\u003eFor all those with an interest in the biology of ageing, this is compulsory reading.\u003c\/p\u003eIn den letzten Jahren hat unser Wissen uber den menschlichen Alterungsproze? betrachlich zugenommen. Altersbedingte Erkrankungen und Sterblichkeit sind von Mensch zu Mensch sehr verschieden. Dieses Buch behandelt die individuellen Unterschiede und die Anfalligkeit fur altersbedingte Erkrankungen. Spezielle Kapitel widmen sich der altersbedingten Pathologie des Gehirns, altersbedingten Prozessen in den Stammzellen sowie altersbedingten Auswirkungen auf das Immunsystem, das Knochen-, Muskel und kardiovaskulare Gewebe. \u003cp\u003eSymposium on Ageing vulnerability: causes and interventions, held at the Novartis Foundation,\u003cbr\u003eLondon, 29 February^3 March 2000\u003c\/p\u003e \u003cp\u003eEditors: Gregory Bock (Organizer) and Jamie A. Goode\u003c\/p\u003e \u003cp\u003eThis symposium is based on a proposal made by Gary Andrews. It was organized as a key component and in support of the United Nations Project ‘A Research Agenda on Ageing for the 21st Century’\u003cbr\u003eThomas B. L. Kirkwood Introduction 1\u003c\/p\u003e \u003cp\u003eGary R. Andrews The priority of basic research on ageing vulnerability in a comprehensive research agenda on ageing for the 21st century 4\u003c\/p\u003e \u003cp\u003eDiscussion 9\u003c\/p\u003e \u003cp\u003eJulie K. Andersen Do alterations in glutathione and iron levels contribute to pathology associated with Parkinson’s disease? 11\u003c\/p\u003e \u003cp\u003eDiscussion 20\u003c\/p\u003e \u003cp\u003eAshley I. Bush and Lee E. Goldstein Specific metal-catalysed protein oxidation reactions in chronic degenerative disorders of ageing: focus on Alzheimer’s disease and age-related cataracts 26\u003c\/p\u003e \u003cp\u003eDiscussion 38\u003c\/p\u003e \u003cp\u003eGeneral discussion I The role of glial cells in the ageing brain 44\u003cbr\u003eR.N. Kalaria, C.G. Ballard, P.G. Ince, R.A. Kenny, I.G. McKeith, C.M. Morris, J.T. O’Brien, E. K. Perry, R.H. Perry and J. A. Edwardson Multiple substrates of late-onset dementia: implications for brain protection 49\u003c\/p\u003e \u003cp\u003eDiscussion 60\u003c\/p\u003e \u003cp\u003eC. S. Potten, K. Martin and T. B. L. Kirkwood Ageing of murine small intestinal stem cells 66\u003c\/p\u003e \u003cp\u003eDiscussion 79\u003c\/p\u003e \u003cp\u003eAmiela Globerson Haematopoietic stem cell ageing 85\u003c\/p\u003e \u003cp\u003eDiscussion 96\u003c\/p\u003e \u003cp\u003eGeneral discussion II 101\u003c\/p\u003e \u003cp\u003eJames K. Leung and Olivia M. Pereira-Smith Identification of genes involved in cell senescence and immortalization: potential implications for tissue ageing 105\u003c\/p\u003e \u003cp\u003eDiscussion 110\u003c\/p\u003e \u003cp\u003eJerry W. Shay and Woodring E.Wright Ageing and cancer: the telomere and telomerase connection 116\u003c\/p\u003e \u003cp\u003eDiscussion 125\u003c\/p\u003e \u003cp\u003eRita B. E¡ros Ageing and the immune system 130\u003c\/p\u003e \u003cp\u003eDiscussion 139\u003c\/p\u003e \u003cp\u003eGeneral discussion III 146\u003c\/p\u003e \u003cp\u003eLis Mosekilde Mechanisms of age-related bone loss 150\u003c\/p\u003e \u003cp\u003eDiscussion 166\u003c\/p\u003e \u003cp\u003eEdward G. Lakatta, Steven J. Sollott and Salvatore Pepe The old heart: operating on the edge 172\u003c\/p\u003e \u003cp\u003eDiscussion 196\u003c\/p\u003e \u003cp\u003eAnthony Cerami and Peter Ulrich Pharmaceutical intervention of advanced glycation end products 202\u003c\/p\u003e \u003cp\u003eDiscussion 212\u003c\/p\u003e \u003cp\u003eGeneral discussion IV 217\u003c\/p\u003e \u003cp\u003eHolly Van Remmen, Zhongmao Guo and Arlan Richardson The anti-ageing action of dietary restriction 221\u003c\/p\u003e \u003cp\u003eDiscussion 230\u003c\/p\u003e \u003cp\u003eD. A. Cottrell, E. L. Blakely, M. A. Johnson, G.M. Borthwick, P. I. Ince and D. M. Turnbull Mitochondrial DNA mutations in disease and ageing 234\u003c\/p\u003e \u003cp\u003eDiscussion 243\u003c\/p\u003e \u003cp\u003eDouglas C. Wallace A mitochondrial paradigm for degenerative diseases and ageing 247\u003c\/p\u003e \u003cp\u003eDiscussion 263\u003c\/p\u003e \u003cp\u003eFinal discussion 267\u003c\/p\u003e \u003cp\u003eIndex of contributors 273\u003c\/p\u003e \u003cp\u003eSubject index 275\u003c\/p\u003e \u003cb\u003eThe Novartis Foundation\u003c\/b\u003e is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research. Ageing at individual and population levels presents one of the greatest challenges to humankind as we enter this new century. Throughout the world today older adults are the fastest growing population groups. Mortality rates have declined in virtually all countries, raising the average life expectancy in the developing countries to the high 60s, and the high 70s in the developed world. Ageing is associated with an increased risk for development of chronic diseases that contribute to morbidity and mortality. It is estimated that by 2020 over two-thirds of deaths in the developing world will be caused by non-communicable diseases. This fact, along with the high levels of chronic morbidity associated with ageing in developed countries, represents a potentially overwhelming stress to health and social care systems globally.\u003cbr\u003e \u003cbr\u003e The frontiers of knowledge in relation to human ageing have been pushed back in recent years and it is to be expected that continuous progress will be made towards understanding the basic ageing processes. Further research is now urgently needed to improve our understanding of the relationship between ageing and the pathogenesis of age-related diseases in order to identify more effective means of prevention, amelioration and management of such diseases, and reduce the social and economic impacts of population ageing and the related burden of age-associated morbidity.\u003cbr\u003e \u003cbr\u003e Age-related morbidity and mortality differ dramatically in different individuals. The focus of this book is on individual differences in susceptibility to age-related disorders. Specific chapters in the book deal with age-related pathology in the brain, age-related processes in stem cells, and age-related effects on the immune system and in bone, muscle and cardiovascular tissue. Bringing together the leading researchers in the ageing field to discuss their work, this book is compulsory reading for all those interested in the biology of ageing.","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47988705919205,"sku":"NP9780471494386","price":211.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780471494386.jpg?v=1761781265","url":"https:\/\/k12savings.com\/es\/products\/ageing-vulnerability-isbn-9780471494386","provider":"K12savings","version":"1.0","type":"link"}