Addiction Reviews 2, Volume 1187

This volume features expert, refereed reviews of timely topics in each of the areas relevant to addiction science and clinical practice to aid researchers and practitioners interested in addictions. Authors from the United States, EU, Asia and elsewhere provide an international perspective on the problems and practices.

Specifically, this volume:

- focuses on topics that are relevant to specific substances but also provides important lessons for addiction to all substances
- provides reviews that are aimed to be useful to specialists in the field and as useful to students as the first criterion allows.

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Introduction to Addiction reviews 2 / by George R. Uhl 1

Preface to Addiction reviews 2 / by George F. Koob 3

Part I. Medications for addiction and relevant neurotransmitter systems.

Current perspectives on selective dopamine D3 receptor antagonists as pharmacotherapeutics for addictions and related disorders / by Christian A. Heidbreder and Amy H. Newman 4

Cocaine-induced neuroadaptations in glutamate transmission : potential therapeutic targets for craving and addiction / by Heath D. Schmidt and R. Christopher Pierce 35

Agonist-like pharmacotherapy for stimulant dependence : preclinical, human laboratory, and clinical studies / by David V. Herin, Craig R. Rush and John Grabowski 76

Part II. Drug and HIV toxicities

Amphetamine toxicities : classical and emerging mechanisms / by Bryan K. Yamamoto, Anna Moszczynska and Gary A. Gudelsky 101

Human immunodeficiency virus-associated neurocognitive disorder : pathophysiology in relation to drug addiction / by Avindra Nath 122

Part III. Physiology.

Synaptic plasticity in the mesolimbic system : therapeutic implications for substance abuse / by Billy T. Chen, F. Woodward Hopf and Antonello Bonci 129

Electrophysiological correlates of abused drugs : relation to natural rewards / by Sam A. Deadwyler 140

Part IV. Imaging.

Neurochemistry of drug action : insights from proton magnetic resonance spectroscopic imaging and their relevance to addiction / by Stephanie C. Licata and Perry F. Renshaw 148

Part V. Development.

Cocaine addiction in mothers : potential effects on maternal care and infant development / by Lane Strathearn and Linda C. Mayes 172

Part VI. Genetics.

Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment / by Vadim Yuferov [and others] 184

Addictions and their familiality in Iceland / by Thorarinn Tyrfingsson [and others] 208

Transgenic mice in the study of drug addiction and the effects of psychostimulant drugs / by Ichiro Sora [and others] 218

Part VII. Behavioral mechanisms.

Conditioned taste aversion learning : implications for animal models of drug abuse / by Catherine M. Davis and Anthony L. Riley 247

Part VIII. Comorbidity.

The strong relationship between bipolar and substance-use disorder : mechanisms and treatment implications / by Alan C. Swann 276

Part IX. Nonsubstance addictions.

Shared brain vulnerabilities open the way for nonsubstance addictions : carving addiction at a new joint? / by Joseph Frascella [and others] 294

Part X. Molecules for addiction.

Regulation of the dopamine transporter : aspects relevant to psychostimulant drugs of abuse / by Kyle C. Schmitt and Maarten E.A. Reith 316

Regulator of G protein-signaling proteins and addictive drugs / by John Traynor 341

Part XI. Epidemiology.

Novel phenotype issues raised in cross-national epidemiological research on drug dependence / by James C. (Jim) Anthony 353

Part XII. Places and institutions.

Office of National Drug Control Policy: A scientist in drug policy in Washington, DC / by Bertha K. Madras. 370

George R. Uhl, NIDA, NIH, Baltimore, MD.