{"product_id":"abnormal-chromosomes-isbn-9781119651987","title":"Abnormal Chromosomes","description":"\u003cb\u003eExplore the past, present, and future of cancer cytogenetics\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003eIn \u003ci\u003eAbnormal Chromosomes: The Past, Present, and Future of Cancer Cytogenetics\u003c\/i\u003e, globally renowned researchers Drs. Sverre Heim and Felix Mitelman deliver a state-of-the-art review of how cancer cytogenetic analyses have contributed to an improved understanding of tumorigenesis as well as to the diagnosis and treatment of cancer patients. The book also discusses how cytogenetics – the study of chromosomes - meets, interacts with, and cross-fertilizes other investigative technologies, including molecular somatic cell genetics.\u003cbr\u003e\u003cbr\u003eThe book provides an impetus to think more deeply about the role chromosomes, and their abnormalities, play in health and disease, especially in neoplastic disorders. From which origins did cytogenetics develop? How did the finding of acquired chromosomal abnormalities in cells of leukemias and solid tumors influence our understanding of cancer as a biological process? How was information of this nature put to good use in the clinical management of cancer patients?\u003cbr\u003e\u003cbr\u003e\u003ci\u003eAbnormal Chromosomes: The Past, Present, and Future of Cancer Cytogenetics\u003c\/i\u003e offers readers:\u003cbr\u003e \u003cul\u003e \u003cli\u003eA thorough introduction to ancient theories of disease, the advent of cellular pathology, and how a scientific interest in chromosomes developed\u003c\/li\u003e \u003cli\u003eComprehensive exploration of the conceptual importance of Theodor Boveri and his somatic mutation theory of cancer\u003c\/li\u003e \u003cli\u003eA detailed chronological resume of cancer cytogenetic discoveries during the 20th century\u003c\/li\u003e \u003cli\u003eIn-depth discussions of the role of chromosome abnormalities, oncogenes, and tumor suppressor genes in leukemias, lymphomas, and solid tumors, together with a survey of what chromosome analyses have revealed about the clonal evolution of neoplastic cell populations\u003c\/li\u003e \u003cli\u003eA discussion of the importance of pathogenetic classifications of neoplastic diseases, the role chromosome abnormalities play in this context, and which technological breakthroughs can be expected in chromosome-oriented cancer research\u003c\/li\u003e \u003c\/ul\u003e \u003ci\u003eAbnormal Chromosomes: The Past, Present, and Future of Cancer Cytogenetics\u003c\/i\u003e was written for everyone with a scientific or clinical interest in cancer, especially how acquired chromosome abnormalities lead to neoplastic transformation. The book teaches how cytogenetic analyses contribute to a better understanding of tumorigenesis, but also how the finding of specific chromosome aberrations can be crucial for the diagnosis, prognosis, and management of cancer patients. \u003cp\u003ePreface vii\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart I Past 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 1 Understanding Disease: Ancient Theories 3\u003c\/p\u003e \u003cp\u003eChapter 2 The Advent of Cellular Pathology 7\u003c\/p\u003e \u003cp\u003eChapter 3 The Colored Bodies of Cell Nuclei: Chromosomes and Heredity 15\u003c\/p\u003e \u003cp\u003eChapter 4 Boveri and the Somatic Mutation Theory of Cancer 23\u003c\/p\u003e \u003cp\u003eChapter 5 Cytogenetics from 1914 to 1960: Slow Progress Followed by Serendipitous Methodological Breakthroughs Leading to Important Discoveries 29\u003c\/p\u003e \u003cp\u003eChapter 6 The First Cancer-Specific Chromosome Aberrations: Ph1 and Others 41\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II Present 57\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 7 The Banding Revolution: Cancer Cytogenetics in the 1970s 59\u003c\/p\u003e \u003cp\u003eChapter 8 Chasing Correlations: Chromosomes and Oncogenes in Leukemias and Lymphomas 75\u003c\/p\u003e \u003cp\u003eChapter 9 Solid Tumor Cytogenetics 87\u003c\/p\u003e \u003cp\u003eChapter 10 Gains, Losses, and Rearrangements of Genomic Material: Pathogenetic Considerations 105\u003c\/p\u003e \u003cp\u003eChapter 11 Morphology Meets Chemistry: Integration of Molecular Genetics into the Cytogenetic Search for Cancer-Specific Chromosome Aberrations 117\u003c\/p\u003e \u003cp\u003eChapter 12 Unraveling the Clonal Evolution of Neoplastic Cell Populations 125\u003c\/p\u003e \u003cp\u003eChapter 13 Clinical Usefulness 137\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III Future 149\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 14 Toward a Pathogenetic Classification of Cancer 151\u003c\/p\u003e \u003cp\u003eChapter 15 Where There is Structure, There is Function 161\u003c\/p\u003e \u003cp\u003eChapter 16 Which Resolution Level is Optimally Suited to\u003c\/p\u003e \u003cp\u003eAnswer Which Questions? Seeing Never Goes Out of Fashion . . . 169\u003c\/p\u003e \u003cp\u003eChapter 17 Are New Technical Breakthroughs on the Horizon? 179\u003c\/p\u003e \u003cp\u003eAfterthoughts 189\u003c\/p\u003e \u003cp\u003eIndex 195\u003c\/p\u003e \u003cb\u003eExplore the past, present, and future of cancer cytogenetics\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003eIn \u003ci\u003eAbnormal Chromosomes: The Past, Present, and Future of Cancer Cytogenetics\u003c\/i\u003e, globally renowned researchers Drs. Sverre Heim and Felix Mitelman deliver a state-of-the-art review of how cancer cytogenetic analyses have contributed to an improved understanding of tumorigenesis as well as to the diagnosis and treatment of cancer patients. The book also discusses how cytogenetics – the study of chromosomes - meets, interacts with, and cross-fertilizes other investigative technologies, including molecular somatic cell genetics.\u003cbr\u003e\u003cbr\u003eThe book provides an impetus to think more deeply about the role chromosomes, and their abnormalities, play in health and disease, especially in neoplastic disorders. From which origins did cytogenetics develop? How did the finding of acquired chromosomal abnormalities in cells of leukemias and solid tumors influence our understanding of cancer as a biological process? How was information of this nature put to good use in the clinical management of cancer patients?\u003cbr\u003e\u003cbr\u003e\u003ci\u003eAbnormal Chromosomes: The Past, Present, and Future of Cancer Cytogenetics\u003c\/i\u003e offers readers:\u003cbr\u003e \u003cul\u003e \u003cli\u003eA thorough introduction to ancient theories of disease, the advent of cellular pathology, and how a scientific interest in chromosomes developed\u003c\/li\u003e \u003cli\u003eComprehensive exploration of the conceptual importance of Theodor Boveri and his somatic mutation theory of cancer\u003c\/li\u003e \u003cli\u003eA detailed chronological resume of cancer cytogenetic discoveries during the 20th century\u003c\/li\u003e \u003cli\u003eIn-depth discussions of the role of chromosome abnormalities, oncogenes, and tumor suppressor genes in leukemias, lymphomas, and solid tumors, together with a survey of what chromosome analyses have revealed about the clonal evolution of neoplastic cell populations\u003c\/li\u003e \u003cli\u003eA discussion of the importance of pathogenetic classifications of neoplastic diseases, the role chromosome abnormalities play in this context, and which technological breakthroughs can be expected in chromosome-oriented cancer research\u003c\/li\u003e \u003c\/ul\u003e \u003ci\u003eAbnormal Chromosomes: The Past, Present, and Future of Cancer Cytogenetics\u003c\/i\u003e was written for everyone with a scientific or clinical interest in cancer, especially how acquired chromosome abnormalities lead to neoplastic transformation. The book teaches how cytogenetic analyses contribute to a better understanding of tumorigenesis, but also how the finding of specific chromosome aberrations can be crucial for the diagnosis, prognosis, and management of cancer patients.","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47988651131109,"sku":"NP9781119651987","price":134.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781119651987.jpg?v=1761781120","url":"https:\/\/k12savings.com\/es\/products\/abnormal-chromosomes-isbn-9781119651987","provider":"K12savings","version":"1.0","type":"link"}