{"product_id":"a-handbook-for-dna-encoded-chemistry-isbn-9781118487686","title":"A Handbook for DNA-Encoded Chemistry","description":"\u003cp\u003e\u003cb\u003eThis book comprehensively describes the development and practice of DNA-encoded library synthesis technology.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eTogether, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eProvides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry\u003c\/li\u003e \u003cli\u003eHelps chemists generate and screen novel chemical libraries of large size and quality\u003c\/li\u003e \u003cli\u003eBridges interdisciplinary areas of DNA-encoded combinatorial chemistry – synthetic and analytical chemistry, molecular biology, informatics, and biochemistry\u003c\/li\u003e \u003cli\u003eShows medicinal and pharmaceutical chemists how to efficiently broaden available \"chemical space\" for drug discovery\u003c\/li\u003e \u003cli\u003eProvides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003ePreface vii\u003c\/p\u003e \u003cp\u003eAcknowledgments ix\u003c\/p\u003e \u003cp\u003eIntroductory Comments xi\u003c\/p\u003e \u003cp\u003eContributors xxiii\u003c\/p\u003e \u003cp\u003e1 Just enough knowledge… 1\u003cbr\u003e\u003ci\u003eAgnieszka Kowalczyk\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 A brief history of the development of combinatorial chemistry and the emerging need for DNA-encoded chemistry 19\u003cbr\u003e\u003ci\u003eRobert A. Goodnow, Jr.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 A brief history of DNA-encoded chemistry 45\u003cbr\u003e\u003ci\u003eAnthony D. Keefe\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 DNA-Compatible Chemistry 67\u003cbr\u003e\u003ci\u003eKin-Chun Luk and Alexander Lee Satz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Foundations of a DNA-encoded library (DEL) 99\u003cbr\u003e\u003ci\u003eAlexander Lee Satz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Exercises in the Synthesis of DNA-encoded Libraries 123\u003cbr\u003e\u003ci\u003eSteffen P. Creaser and Raksha A. Acharya\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 The DNA Tag: A Chemical gene designed for DNA-encoded libraries 153\u003cbr\u003e\u003ci\u003eAndrew W. Fraley\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Analytical challenges for DNA-encoded library systems 171\u003cbr\u003e\u003ci\u003eGeorge L. Perkins and G. John Langley\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Informatics: Functionality and architecture for DNA-encoded library production and screening 201\u003cbr\u003e\u003ci\u003eJohn A. Feinberg and Zhengwei Peng\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Theoretical considerations of the application of DNA-encoded libraries to drug discovery 213\u003cbr\u003e\u003ci\u003eCharles Wartchow\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Begin with the End in Mind: The hit-to-lead process 231\u003cbr\u003e\u003ci\u003eJohn Proudfoot\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Enumeration and Visualization of Large Combinatorial Chemical Libraries 247\u003cbr\u003e\u003ci\u003eSung-Sau So\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Screening Large Compound Collections 281\u003cbr\u003e\u003ci\u003eStephen P. Hale\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Reported applications of DNA-encoded library chemistry 319\u003cbr\u003e\u003ci\u003eJohannes Ottl\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Dual-Pharmacophore DNA-encoded Chemical Libraries 349\u003cbr\u003e\u003ci\u003eJörg Scheuermann and Dario Neri\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Hit Identification and Hit Follow-up 357\u003cbr\u003e\u003ci\u003eYixin Zhang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 Using DNA to Program Chemical Synthesis, Discover New Reactions, and Detect Ligand Binding 377\u003cbr\u003e\u003ci\u003eLynn M. McGregor and David R. Liu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 The changing feasibility and economics of chemical diversity exploration with DNA-encoded combinatorial approaches 417\u003cbr\u003e\u003ci\u003eRobert A. Goodnow, Jr.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19 Keeping the promise? An outlook on DNA chemical library technology 427\u003cbr\u003e\u003ci\u003eSamu Melkko and Johannes Ottl\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 435\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eROBERT A. GOODNOW, J\u003csmall\u003eR\u003c\/small\u003e.\u003c\/b\u003e is the Executive Director of the Chemistry Innovation Centre, Discovery Sciences at AstraZeneca and the Founder of GoodChem Consulting, LLC. He has extensive experience in drug discovery and chemistry technologies including carbohydrate, combinatorial, oligonucleotide, and analytical chemistry. Robert Goodnow has authored or coauthored nearly 100 publications and patents and has spoken extensively on the topics of drug lead finding and the outsourcing of drug discovery chemistry. He has lectured as an adjunct professor of medicinal chemistry.   \u003c\/p\u003e\u003cp\u003e\u003cb\u003eThe theory, methods, and practices needed to generate and screen very large, high-quality, small molecule, and DNA-encoded libraries\u003c\/b\u003e  \u003c\/p\u003e\u003cp\u003eDescribing the development and practice of DNA-encoded library synthesis technology, this book expertly details an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery, and fragment-based screening. \u003ci\u003eA Handbook for DNA-Encoded Chemistry\u003c\/i\u003e is comprised of chapters summarizing practical methods, theoretical analysis, and reported applications. Important aspects of this technology, including DNA-compatible chemistry, DNA-encoded library synthesis, design of \"chemical genes,\" analytical methods for small molecule-DNA libraries, selection methods, hit identification, and DNA-directed chemistry are explored. \u003c\/p\u003e\u003cp\u003eThis book offers practicing chemists a variety of benefits: \u003c\/p\u003e\u003cul\u003e \u003cli\u003eGuidance for understanding and applying DNA-encoded combinatorial chemistry to generate and screen novel chemical libraries\u003c\/li\u003e \u003cli\u003eA bridge to the interdisciplinary areas of DNA-encoded combinatorial chemistry— synthetic and analytical chemistry, molecular biology, informatics, and biochemistry\u003c\/li\u003e \u003cli\u003eInstruction for medicinal and pharmaceutical chemists to efficiently broaden available \"chemical space\" for drug discovery\u003c\/li\u003e \u003cli\u003e Expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eDespite many publications from laboratories specializing in DNA-encoded chemistry published since 1992, there has been no technical handbook offering this level of detail.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47988631011557,"sku":"NP9781118487686","price":138.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118487686.jpg?v=1761781044","url":"https:\/\/k12savings.com\/es\/products\/a-handbook-for-dna-encoded-chemistry-isbn-9781118487686","provider":"K12savings","version":"1.0","type":"link"}