Metabolic Risk for Cardiovascular Disease

The relationship of metabolic diseases to cardiovascular disease (CVD) is reaching epidemic proportions. This relates mostly to the increasing prevalence of obesity, the metabolic syndrome and type 2 diabetes.

This book outlines and addresses the metabolic factors and related diseases that contribute to CVD, including brief introductions to metabolic pathways including lipid and lipoprotein metabolism, macronutrient fuel partitioning, insulin action and body weight regulation. Mechanisms that relate to becoming obese, maintenance of the obese state, the dyslipidemias, and glucose intolerance/diabetes are also addressed, and the importance of interventions that reduce metabolic risk factors and CVD are covered.

Contributors.

Foreword.

1 Insulin action and beta-cell function: role in metabolic regulation (Kristina M. Utzschneider and Steven E. Kahn).

2 Lipid and lipoprotein metabolism, and risk for cardiovascular disease (Frank M. Sacks).

3 Tobacco and risk for cardiovascular disease (C. Barr Taylor and Mickey Trockel).

4 Nutrition and risk for cardiovascular disease (Alice H. Lichtenstein).

5 Physical activity and cardiovascular health (William E. Kraus and William L. Haskell).

6 The obesity epidemic and cardiovascular risk (Paul Poirier).

7 Insulin resistance, the metabolic syndrome, and cardiovascular risk (Stanley S. Wang and Sidney C. Smith, Jr).

8 Diabetes mellitus and cardiovascular risk (Peter W. F. Wilson).

9 Lipid management and cardiovascular risk reduction (Antonio M. Gotto, Jr. and John A. Farmer).

10 Obesity management and cardiovascular risk reduction (George A. Bray).

11 Diabetes management and cardiovascular risk reduction (Jay S. Skyler).

12 A healthy lifestyle and cardiovascular risk reduction (Arne V. Astrup).

Index.

Author Disclosure Table.

"This book gives a clear overview of metabolic risk factors associated with cardiovascular risk, along with risk reduction strategies." (Doody's, 14 October 2011)
Robert H. Eckel, M.D. received both his Bachelor of Sciences in Bacteriology and Medical Doctorate from the University of Cincinnati. He did his Housestaff training in Internal Medicine at the University of Wisconsin Hospitals and from there traveled to Seattle for a senior fellowship in Endocrinology and Metabolism. Dr. Eckel was then appointed as Assistant Professor of Medicine at the University of Colorado School of Medicine where he is now Professor of Medicine and holds the Charles A. Boettcher Endowed Chair in Atherosclerosis. In addition, Dr. Eckel holds a joint appointment in the Department of Physiology and Biophysics and adjunct appointments in the School of Pharmacy, the Department of Integrative Physiology at the University of Colorado at Boulder, and in the Department of Food Science and Human Nutrition at Colorado State University. Dr. Eckel currently directs the campus wide Program in Preventive Cardiology at the University of Colorado at Denver and Health Sciences Center.
Shortly after his arrival in Denver, Dr. Eckel was appointed Associate Program Director of the Adult General Clinical Research Center (GCRC) at the University of Colorado Health Sciences Center (UCHSC). In 1993 he assumed the role of Program Director, a position he continues to hold. Dr. Eckel’s translational research in lipid and lipoprotein metabolism, insulin action, energy balance and body weight regulation has led to a number of awards, and his presidency of the Western Society for Clinical Investigation, the North American Association for the Study of Obesity, the Association for Patient Oriented Research, and the American Heart Association. This important new volume presents the current state of knowledge on the relationship between obesity, diabetes, and other metabolic factors and cardiovascular disease. Under the editorial guidance of Dr. Robert H. Eckel, an international team of contributors:

• Outlines and addresses the metabolic factors and related diseases that contribute to cardiovascular disease (CVD)
• Describes key metabolic pathways including lipid and lipoprotein metabolism, macronutrient fuel partitioning, insulin action, and body weight regulation
• Discusses the mechanisms that relate to becoming obese, maintenance of the obese state, the dyslipidemias, and glucose intolerance/diabetes
• Covers in depth the interventions that can reduce metabolic risk factors and CVD

Individual chapters cover key topics such as:

• Nutrition and CVD Risk
• Physical Activity and Cardiovascular Health
• The Obesity Epidemic
• Insulin Resistance
• Diabetes and CVD Risk
• Lifestyle choices that can enhance CVD prevention
• And more.

As the patient population ages and more and more individuals have either important risk factors or obesity and/or type 2 diabetes, the need for clear and practical guidance on the metabolic risks for CVD could not be greater. This book provides essential information that clinicians can put to use right away to optimize patient care.