Laboratory Animal Endocrinology

The complex and fascinating subject of endocrinology can often seem rather daunting for non-specialists. For practising endocrinologists too, maintaining a broad overview of the subject can be a major task. Laboratory Animal Endocrinology has been written with both these audiences in mind. Focusing on the species regularly used in experimental studies (including rodents, dogs and monkeys), each chapter presents a wealth of information on hormone structure, synthesis, secretion, receptors, second messengers and their actions, and considers the various physiological and pharmacological processes which may be involved in hormonal regulation. Interspecies' differences in hormonal structure, metabolism and interactions with drugs and other chemicals are particularly important to toxicologists and in drug safety evaluation. Laboratory Animal Endocrinology also explores these areas of research and provides much-needed support for the interpolation of endocrine data from one test species to another and to humans. The book is not intended exclusively for toxicologists however, but will prove indispensable for all those working with laboratory animals.Eine für den Laboralltag unverzichtbare Informationsquelle zu allen Tierarten - Hunden, Nagetieren und Affen -, die in der experimentellen Toxikologie eingesetzt werden. Jedes Kapitel enthält Angaben zur Hormonstruktur, Synthese, Sekretion und Rezeptoren; ein spezieller Abschnitt beschäftigt sich mit Wirkstoffeffekten und toxikologischen Aspekten. Auch für Nicht-Endokrinologen, die mit Labortieren arbeiten! Organisation of Endocrine Systems.

Endocrine Evolution.

The Hypothalamus.

The Pituitary.

Thyroid and Parathyroid Hormones.

The Adrenal Glands.

Atrial Natriuretic Factor.

The Endocrine Pancreas.

Gastrointestinal Hormones.

Reproductive Hormones.

Endothelin.

Erythropoietin.

Index. Aus dem Inhalt:
Organisation of Endocrine Systems;
Evolution of Interspecies Variation;
The Hypothalamus: Corticotropin Releasing Factor;
Growth Hormone Releasing Hormone;
Somatostatin;
Gonadotrophin Releasing Hormone;
Thyrotropin Releasing Hormone;
The Pituitary: The Anterior Pituitary: Proopiomelanocortin Related peptides;
Luteinizing Hormone and Follicle Stimulating Hormone;
Prolactin;
Growth Hormone;
Thyroid Stimulating Hormone;
The Posterior Pituitary: Arginine Vasopressin;
Oxytocin;
The Thyroid and Parathyroid: Thyroxine, Triiodothyronine and Reverse Triiodothyronine;
Calcitonin, Calcitonin Gene Related Peptide;
Parathyroid Hormone;
The Adrenal: The Adrenal Cortex: Mineralocorticoids;
Glucocorticoids;
Adrenal Androgens;
The Adrenal Medulla: Adrenaline;
Noradrenaline;
Natriuretic Peptides;
The Endocrine Pancreas: Insulin;
Glucagon;
Islet Amyloid Peptide;
Pancreastatin;
Pancreatic Polypeptide;
Gastrointestinal Hormones: Gastrin;
Cholecystokinin;
Somatostatin;
Vasoactive Intestinal Peptide;
Secretin;
Motilin;
Gastrin Releasing Peptide;
Substance P and the Neurokinins;
Peptide YY and Neuropeptide Y;
Gastric Inhibitory Peptide;
Intestinal Glucagon;
Neurotensin;
Galanin;
Gonadal and Reproductive Hormones: Testosterone;
Oestrogens and Progesterone;
Inhibin, Activin and Follistatin;
Relaxin;
Placental Lactogens;
Endothelin;
Erythropoeitin. About the Author Now a freelance toxicology consultant, David Woodman began his research career investigating the endocrine and physiological sequalae of stress in socially deviant populations. This initial interest in endocrinology and hormones led to many years in the pharmaceutical industry, where the author gained practical experience and expert knowledge in toxicology and drug safety with SmithKline Beecham. The complex and fascinating subject of endocrinology can often seem rather daunting for non-specialists. For practising endocrinologists too, maintaining a broad overview of the subject can be a major task. Laboratory Animal Endocrinology has been written with both these audiences in mind. Focusing on the species regularly used in experimental studies (including rodents, dogs and monkeys), each chapter presents a wealth of information on hormone structure, synthesis, secretion, receptors, second messengers and their actions, and considers the various physiological and pharmacological processes which may be involved in hormonal regulation. Interspecies' differences in hormonal structure, metabolism and interactions with drugs and other chemicals are particularly important to toxicologists and in drug safety evaluation. Laboratory Animal Endocrinology also explores these areas of research and provides much-needed support for the interpolation of endocrine data from one test species to another and to humans. The book is not intended exclusively for toxicologists however, but will prove indispensable for all those working with laboratory animals.