The Renaissance of Cancer Immunotherapy

This Annals volume includes invited short reviews on topics presented at the 7th International Cancer Vaccine Symposium “Renaissance of Cancer Immunotherapy”, held September 9-11, 2012 in Florence, Italy. The papers cover the latest progress in basic immunology research and its translation to cancer patients. The meeting and papers pay tribute to the successes in the last few years that have led to the approval of new immunotherapies and the awarding of the Nobel Prize in medicine to three immunologists. The symposium is dedicated to one of these recipients, Dr. Ralph Steinman who discovered dendritic cells, immune cells that are vital in immune responses and immunotherapies for cancer.

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Introduction to The Renaissance of Cancer Immunotherapy v
Olivera J. Finn and Gerold Schuler

Cancer immunoediting: antigens, mechanisms, and implications to cancer immunotherapy 1
Matthews D. Vesely and Robert D. Schreiber

Cell-extrinsic effects of the tumor unfolded protein response on myeloid cells and T cells 6
Maurizio Zanetti

Immunotherapy in preneoplastic disease: targeting early procarcinogenic inflammatory changes that lead to immune suppression and tumor tolerance 12
Bridget Keenan and Elizabeth M. Jaffee

Integration of epidemiology, immunobiology, and translational research for brain tumors 17
Hideho Okada, Michael E. Scheurer, Saumendra N. Sarkar, and Melissa L. Bondy

Human dendritic cells subsets as targets and vectors for therapy 24
Eynav Klechevsky and Jacques Banchereau

Dendritic cell immunotherapy 31
Rachel Lubong Sabado and Nina Bhardwaj

Molecular programming of steady-state dendritic cells: impact on autoimmunity and tumor immune surveillance 46
Dylan J. Johnson and Pamela S. Ohashi

Preventing cancer by targeting abnormally expressed self-antigens: MUC1 vaccines for prevention of epithelial adenocarcinomas 52
Pamela L. Beatty and Olivera J. Finn

Immunological control of cell cycle aberrations for avoidance of oncogenesis: the case of tetraploidy 57
Laura Senovilla, Lorenzo Galluzzi, Maria Castedo, and Guido Kroemer

Ongoing adaptive immune responses in the microenvironment of melanoma metastases 62
Nicolas van Baren and Pierre G. Coulie

Main features of human T helper 17 cells 66
Francesco Annunziato, Lorenzo Cosmi, Francesco Liotta, Enrico Maggi, and Sergio Romagnani

In silico modeling of cancel cell dissemination and metastasis 71
Lu-En Wai, Vipin Narang, Alexandre Gouaillard, Lai Guan Ng, and Jean-Pierre Abastado

Common pathways to tumor rejection 75
Ena Wang, Davide Bedognetti, Sara Tomei, and Francesco M. Marincola

Cancer-induced immunosuppressive cascades and their reversal by molecular-targeted therapy 80
Yutaka Kawakami, Tomonori Yaguchi, Hidetoshi Sumimoto, Chie Kudo-Saito, Nobuo Tsukamoto. Tomoko Iwata-Kajihara, Shoko Nakamura, Hiroshi Nishio, Ryosuke Satomi, Asuka Kobayashi, Mayuri Tanaka, Jeong Hoon Park, Hajime Kamijuku, Takahiro Tsujikawa, and Naoshi Kawamura

Olivera J. Finn is a Yugoslav-American immunologist who is a distinguished professor and former chair of the Department of Immunology at the University of Pittsburgh and former director of the Cancer Immunology Program at the University of Pittsburgh Cancer Institute. Gerold Schuler is the editor of The Renaissance of Cancer Immunotherapy: The 7th International Cancer Vaccine Symposium, Volume 1284, published by Wiley.