The Lock-and-Key Principle

Published 100 years after Emil Fischer first proposed the lock-and-key principle, this volume provides a complete review of the subject to date and offers suggestions for futher research. The major impact of the lock-and-key principle on the chemical, biomedical and materials sciences is discussed by leaders in the field, with chapters dedicated to molecular recognition, nucleic acid and protein chemistry, crystallography and the development of Emil Fischer's initial ideas. The Lock-and-Key Principle is the most up-to-date review of progress in supramolecular chemistry and the lock-and-key principle and will become the essential guide to the past, present and future of this remarkable principle.

Contributors vii

Preface ix

1 Emil Fischer’s Lock-and-Key Hypothesis after 100 Years—Towards a Supracellular Chemistry 1

Friedrich Cramer

2 Molecular Recognition in Biology: Models for Analysis of Protein-Ligand Interactions 25

Doron Lancet, Amnon Horovitz and Ephraim Katchalski-Katzir

3 New Biocatalysts via Chemical Modification 73

Ian M. Bell and Donald Hilvert

4 Oligonucleotides: Superspecific Ligands for Targeting Nucleic Acids and Proteins and Development of Molecular Devices 89

V. V. Vlassov

5 Macrocycles and Antibodies as Catalysts 149

D. B. Smithrud and S. J. Benkovic

6 Lock-and-Key Processes at Crystalline Interfaces: Relevance to the Spontaneous Generation of Chirality 173

Isabelle Weissbuch, Ronit Popovitz-Biro, Leslie Leiscrowitz and Meir Lahav

7 A Model of the Origin of Life and Perspectives in Supramolecular Engineering 247

H. Kuhn and J. Waser

8 Perspectives in Supramolecular Chemistry—From the Lock-and-Key Image to the Information Paradigm 307

Jean-Marie Lehn

Index 319

Jean-Paul Behr is the editor of The Lock-and-Key Principle: The State of the Art--100 Years On, published by Wiley.

Perspectives in Supramolecular Chemistry Editorial Board Founding Editor J.-M. Lehn, Université Louis Pasteur, Strasbourg, France Editors J.-P. Behr, Université Louis Pasteur, Strasbourg, France G. R. Desiraju, University of Hyderabad, Hyderabad, India A. D. Hamilton, University of Pittsburgh, Pittsburgh, USA T. Kunitake, Kyushu University, Fukuoka, Japan D.N. Reinhoudt, University of Twente, AE Enschede, The Netherlands J.-P. Sauvage, Université Louis Pasteur, Strasbourg, France

Perspectives in Supramolecular Chemistry — Volume 1 The Lock and Key Principle The State of the Art—100 Years On Edited by Jean-Paul Behr Université Louis Pasteur, Strasbourg, France Contributors Ian M. Bell, The Scripps Research Institute, La Jolla, USA S. J. Benkovic, Pennsylvania State University, Pennsylvania, USA F. Cramer, Max-Plank Institut für Experimentelle Medizin, Göttingen, Germany D. Hilvert, The Scripps Research Institute, La Jolla, USA E. A. Horovitz, The Weizmann Institute of Science, Rehovot, Israel E. Katchalski-Katzir, The Weizmann Institute of Science, Rehovot, Israel H. Kuhn, formerly Max-Planck-Institut für biophysikalische Chemie, Göttingen M. Lahav, The Weizmann Institute of Science, Rehovot, Israel D. Lancet, The Weizmann Institute of Science, Rehovot, Israel J.-M. Lehn, Université Louis Pasteur, Strasbourg, France L. Leiserowitz The Weizmann Institute of Science, Rehovot, Israel D. B. Smithrud, Pennsylvania State University, Pennsylvania, USA V. V. Vlassov, Institute of Bioorganic Chemistry, Novosibirsk, Russia

Forthcoming titles in Perspectives in Supramolecular Chemistry Volume 2: Supramolecular Chemistry in the Solid State Edited by Gautam Desiraju, University of Hyderabad, India

This volume will concentrate on the crystalline structures of supramolecules. Contributions will include Crystals as Supramolecules, Molecular Shape Considerations in Crystals Engineering, The Intermolecular Implication of Protein Function and Molecular Engineering of Crystals by Electrostatic Templating. Volume 3: Supramolecular Control of Structure and Reactivity Edited by Andrew Hamilton, Massachusetts Institute of Technology, Cambridge, USA This volume will deal with the catalytic properties of supramolecules, particularly in biological systems. Topics covered include Design of Self-Replicating Molecules, Synthetic Control of Oligonucleotide Structure, Micellar Catalysis and A Survey of Recent Developments in Supramolecular Catalysis.