Basic Cardiac Electrophysiology for the Clinician

This book translates fundamental knowledge in basic cardiac electrophysiology from the bench to the bedside. Revised and updated for its second edition, the text offers new coverage of the molecular mechanisms of ion channel behavior and its regulation, complex arrhythmias, and the broadening roles of devices and ablation. Clear, straightforward explanations are illustrated by plentiful diagrams to make the material accessible to the non-specialist. Acknowledgments, vii

Foreword to the Second Edition by Douglas P. Zipes, ix

Foreword to the First Edition by Douglas P. Zipes, xi

Introduction, 1

Chapter 1 Bioelectricity, 7

Chapter 2 Ion Channels, 43

Chapter 3 Ion Channel Regulation, 72

Chapter 4 Impulse Initiation and Propagation in Cardiac Muscle, 92

Chapter 5 Rate Dependency of Discontinuous Propagation, 121

Chapter 6 Basic Mechanisms of Cardiac Arrhythmias, 152

Chapter 7 Rotors, Spirals, and Scroll Waves in the Heart, 191

Chapter 8 Rotors and the Mechanisms of Atrial Fibrillation, 224

Chapter 9 Molecular Mechanisms of Ventricular Fibrillation, 254

Chapter 10 Inheritable Arrhythmogenic Diseases, 276

Bibliography, 316

Index, 335

José Jalife, M.D., F.A.C.C., F.H.R.S.
Professor and Chairman of Pharmacology
Professor of Medicine and Pediatrics
Director, Institute for Cardiovascular Research
SUNY Upstate Medical University
Syracuse, NY

Mario Delmar, M.D., Ph.D., F.H.R.S.
Professor of Pharmacology
Co-Director, Institute for Cardiovascular Research
SUNY Upstate Medical University
Syracuse, NY

Justus Anumonwo, Ph.D.
Assistant Professor of Pharmacology
Member, Institute for Cardiovascular Research
SUNY Upstate Medical University
Syracuse, NY

Omer Berenfeld

Jerome Kalifa