Advances in Enzymology and Related Areas of Molecular Biology, Volume 75

Advances in Enzymology and Related Areas of Molecular Biology covers the advances in enzymology, explaining the behavior of enzymes and how they can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. Contributors.

Preface.

Abstracts.

Molecular Paleoscience: Systems Biology from the Past (Steven A. Benner, Slim O. Sassi, and Eric A. Gaucher).

A Structure-Centric View of Protein Evolution, Design, and Adaptation (Eric J. Deeds and Eugene I. Shakhnovich).

Mechanisms of Protein Evolution and Their Application to Protein Engineering (Margaret E. Glasner, John A. Gerlt, and Patricia C. Babbitt).

Novel Enzymes Through Design and Evolution (Kenneth J. Woycechowsky, Katherina Vamvaca, and Donald Hilvert).

Author Index.

Subject Index.

ERIC J. TOONE is Professor of Chemistry and Professor of Biochemistry at Duke University in Durham, North Carolina. Volume 75 in the classic series Advances in Enzymology and Related Areas of Molecular Biology explores the area of protein evolution. This volume considers mechanisms of protein evolution broadly, including the use of evolutionary archeology to trace protein evolution, the conservation of structure–rather than sequence–in protein evolution, and the use of directed evolution to create new enzyme activities.

Chapters include:

• Molecular Paleoscience: Systems Biology from the Past
• A Structure-Centric View of Protein Evolution, Design, and Adaptation
• Mechanisms of Protein Evolution and Their Applications to Protein Engineering
• Novel Enzymes Through Design and Evolution