Skeletal Biology and Medicine II

The volume features current basic, clinical, and translational research on aspects of skeletal morphogenesis and remodeling in health and disease. Papers survey vital new insights into the mechanisms of bone development and restructuring, including cellular and mechanical triggers, receptors and signaling pathways. Also covered are the effects of other physiological systems and disease states, such as immune system inflammation, diabetes, infection, and cancer on musculoskeletal health. Recent findings are shaping therapeutic directions that focus on both anti-resorptive and anabolic therapies.

Basic scientists, clinical investigators, and clinicians with interests spanning endocrinology, physiology, cell biology, pathology, genetics, molecular biology, rheumatology, oncology, and other areas that relate to bone development and homeostasis will find this a valuable resource for the most recent developments in skeletal biology and medicine.

This volume presents manuscripts stemming from the 4th New York Skeletal Biology and Medicine Conference, held at Mount Sinai School of Medicine in New York City on April 27–30, 2011. The papers included in this volume include two of the topic areas presented at the conference; the other topic areas are included in Skeletal Biology and Medicine I.

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How are osteoclasts induced to resorb bone? / T.J. Chambers and K. Fuller

Epigenetic regulation of osteoclast differentiation / Tetsuro Yasui [and others]

The osteoclast and its unique cytoskeleton / Steven L. Teitelbaum

HDAC inhibitor trichostatin A suppresses osteoclastogenesis by upregulating the expression of C/EBP-[beta] and MKP-1 / Paul J. Williams, Kazi Nishu, and Md Mizanur Rahman

Skeletal receptors for steroid-family regulating glycoprotein hormones :a multilevel, integrated physiological control system / Harry C. Blair [and others]

Mechanotransduction and cartilage integrity / Daniel J. Leong [and others]

Corticosteroid-associated avascular necrosis : dose relationships and early diagnosis / Roy K. Aaron [and others]

Measuring intranodal pressure and lymph viscosity to elucidate mechanisms of arthritic flare and therapeutic outcomes / Echoe M. Bouta [and others]

Genetic determinants of Paget's disease of bone / Stuart H. Ralston and Omar M.E. Albagha

Recent progress in understanding molecular mechanisms of cartilage degeneration during osteoarthritis / Meina Wang [and others]

Pathogenesis of diabetic neuropathy : bad to the bone / Lawrence Chan [and others]

Noninvasive imaging of bone microarchitecture / Janina M. Patsch [and others]

Mone Zaidi is the editor of Skeletal Biology and Medicine II: Bone and cartilage homeostasis and bone disease, Volume 1240, published by Wiley.