Organic Synthesis

Organic Synthesis: Strategy and Control is a sequel to Stuart Warren's bestseller Organic Synthesis: The Disconnection Approach. The 'Disconnection' book concentrated on the planning behind the synthesis of compounds.

The two themes of this new book are strategy and control: solving problems either by finding an alternative strategy or by controlling any established strategy to make it work.

The book is divided into five sections that deal with selectivity, carbon-carbon single bonds, carbon-carbon double bonds, stereochemistry and functional group strategy. Interpenetrating this structure, the 36 chapters start with classic methods and progress to modern methods and modern strategic considerations. Heterocyclic chemistry is treated throughout the book with full mechanistic explanations as part of organic chemistry rather than a separate mystery.

• A comprehensive, practical account of the key concepts involved in synthesising compounds.
• Takes a mechanistic approach, which explains reactions and gives guidelines on how reactions might behave in different situations.
• Focuses on reactions that really work rather than those with limited application.
• Extensive, up-to-date references in each chapter.

Students and professional chemists familiar with Organic Synthesis: The Disconnection Approach will enjoy the leap into a book designed for chemists at the coalface of organic synthesis.

Preface.

A: Introduction: Selectivity.

1. Planning Organic Syntheses: Tactics, Strategy, andControl.

2. Chemoselectivity.

3. Regioselectivity: Controlled Aldol Reactions.

4. Stereoselectivity: Stereoselective AldolReactions.

5. Alternative Strategies for Enone Synthesis.

6. Choosing a Strategy : The Synthesis ofcyclopentenones.

B: Making Carbon-Carbon Bonds.

7. The Ortho Strategy for Aromatic Compounds.

8. delta-Complexes of Metals.

9. Controlling the Michael Reaction.

10. Specific Enol Equivalents.

11. Extended Enolates.

12. Allyl Anions.

13. Homoenolates.

14. Acyl Anion Equivalents.

C: Carbon-Carbon Double Bonds.

15. Synthesis of Double Bonds of DefinedStereochemistry.

16. Stereo-Controlled Vinyl Anion Equivalents.

17. Electrophilic Attack on Alkenes.

18. Vinyl Cations: Palladium-Catalysed C-CCoupling.

19. Allyl Alcohols: Allyl Cation Equivalents (andMore).

D: Stereochemistry.

20. Control of Stereochemistry -- Introduction.

21 Controlling Relative Stereochemistry.

22. Resolution.

23. The Chiral Pool.

24. Asymmetric Induction I: Reagent-Based Strategy.

25. Asymmetric Induction II: Asymmetric Catalysis:Formation of C-O and C-N Bonds.

26. Asymmetric Induction III: Asymmetric Catalysis:Formation of C-H and C-C Bonds.

27. Asymmetric Induction IV: Substrate-BasedStrategy.

28. Kinetic Resolution.

29. Enzymes: Biological Methods in AsymmetricSynthesis.

30. New Chiral Centres from Old --Enantiomerically Pure Compounds & SophisticatedSyntheses.

31. Strategy of Asymmetric Synthesis.

E: Functional Group Strategy.

32. Functionalisation of Pyridine.

33. Oxidation of Aromatic Compounds, Enols andEnolates.

34. Functionality and Pericyclic Reactions: NitrogenHeterocycles by Cycloadditions and Sigmatropic Rearrangements.

35. Synthesis and Chemistry of Azoles and otherHeterocycles with Two or more Heteroatoms.

36. Tandem Organic Reactions.

General References.

Index. "The authors can be commended on producing a really useful and enjoyable new book on Organic Synthesis! … .Rewarding to read." (The Higher Education Academy Physical Sciences Centre, June 2008)

Paul Wyatt, Senior Lecturer and Director of Undergraduate Studies, School of Chemistry, University of Bristol, UK.

Stuart Warren, Reader in Organic Chemistry, Department of Chemistry, University of Cambridge, UK.

Organic Synthesis: Strategy and Control is a sequel to Stuart Warren's bestseller Organic Synthesis: The Disconnection Approach. The 'Disconnection' book concentrated on the planning behind the synthesis of compounds.

The two themes of this new book are strategy and control: solving problems either by finding an alternative strategy or by controlling any established strategy to make it work.

The book is divided into five sections that deal with selectivity, carbon-carbon single bonds, carbon-carbon double bonds, stereochemistry and functional group strategy. Interpenetrating this structure, the 36 chapters start with classic methods and progress to modern methods and modern strategic considerations. Heterocyclic chemistry is treated throughout the book with full mechanistic explanations as part of organic chemistry rather than a separate mystery.

• A comprehensive, practical account of the key concepts involved in synthesising compounds.
• Takes a mechanistic approach, which explains reactions and gives guidelines on how reactions might behave in different situations.
• Focuses on reactions that really work rather than those with limited application.
• Extensive, up-to-date references in each chapter.

Students and professional chemists familiar with Organic Synthesis: The Disconnection Approach will enjoy the leap into a book designed for chemists at the coalface of organic synthesis.