The Metabolic Syndrome

The Metabolic Syndrome is a valuable reference text, covering all aspects of the metabolic syndrome and its constituent diseases including inflammation, oxidation and adipocytokines. This book explains the aetiology, pathogenesis and clinical treatment of all risk factors as well as the relationship with diabetes, non alcoholic fatty liver disease, polycystic ovary syndrome and coronary heart disease.

The Metabolic Syndrome has been further improved from the 1^st edition that was highly commended in 2006 Annual British Medical Association medical books competition. All chapters from the first edition are fully updated and this new edition contains an increase in international contributions and five new chapters on:

• Childhood obesity and metabolic syndrome
• Bariatric surgery for obesity
• Fitness
• Brain insulin resistance and appetite
• The nature of the insulin resistance seen in metabolic syndrome.

This brand new edition of The Metabolic Syndrome will be an indispensable resource for all clinical researchers, physicians and scientists requiring detailed up-to-date information on the metabolic syndrome to further their own research or to treat and manage the syndrome and its complications. Specifically, the text will be of particular relevance to those involved and working in the fields of diabetes, endocrinology, obesity, cardiology, vascular disease and hepatology.

List of Contributors vii

Foreword, Professor Sir George Alberti xi

Preface xiii

1 The Epidemiology of the Metabolic Syndrome and its Association with Diabetes, Cardiovascular Disease and Other Conditions 1
Sarah H. Wild and Christopher D. Byrne

2 Metabolic Syndrome and Ethnicity 19
Therese Tillin and Nita G. Forouhi

3 Developmental Origins of Endothelial Dysfunction: a Key Step in Cardiometabolic Disease 45
Christopher Torrens, Geraldine F. Clough and Mark A. Hanson

4 Developmental Origins of Insulin Resistance and Type 2 Diabetes 60
Susan E. Ozanne and Kenneth Siddle

5 The Metabolic Syndrome in Childhood 81
Ram Weiss and Sonia Caprio

6 Assessment of Insulin Sensitivity 88
Julia Szendroedi, Esther Phielix and Michael Roden

7 Recent Progress in Identifying Genes Contributing to Type 2 Diabetes and Metabolic Syndrome 106
Weijia Xie, Timothy M. Frayling and Michael N. Weedon

8 Endocrine Aspects of the Metabolic Syndrome 120
Richard I.G. Holt and Peter H. Sönksen

9 Brain Insulin Resistance 139
Katharine F. Hunt, Yee Seun Cheah and Stephanie A. Amiel

10 Cardiorespiratory Fitness and the Metabolic Syndrome 165
Paul A. McAuley and Steven N. Blair

11 Metabolic Syndrome and Mental Illness 177
Richard I.G. Holt and Robert C. Peveler

12 Atherothrombosis and the Metabolic Syndrome 194
Kristina F. Standeven and Peter J. Grant

13 Inflammation and Metabolic Syndrome 210
Sridevi Devaraj, David Siegel and Ishwarlal Jialal

14 Adipocytokine Dysregulation, Obesity and the Metabolic Syndrome 229
Ulf Smith and Xiaolin Yang

15 Non-Alcoholic Fatty Liver Disease 245
Mohamed H. Ahmed and Christopher D. Byrne

16 Polycystic Ovary Syndrome 278
Naveed Sattar

17 Nutrition: Its Relevance in Development and Treatment of the Metabolic Syndrome 297
Lisa Te Morenga and Jim Mann

18 Treatments for the Metabolic Syndrome 327
Markolf Hanefeld, Ulrike Schatz and Frank Schaper

19 Metabolic/Bariatric Surgery Therapy for the Metabolic Syndrome 347
Henry Buchwald

Index 357

"It's rare to find an academic book as engaging as this one. While clearly focused on a specific disease entity, the magnitude of the metabolic disease epidemic coupled with the comprehensive review of the topic this book delivers, should make it interesting reading to a diverse audience." (Doody's, 3 February 2012)

"This excellent book must be considered the flagship text in the Wiley series encompassing obesity, diabetes and insulin resistance." (Practical Diabetes, 2011)

"In all, the text provides a valuable summary of current knowledge, and it may even convince doubters of the existence of the metabolic syndrome! The information that is provided will be of considerable interest to both applied scientists and clinicians who study and treat the epidemics of physical inactivity and obesity that currently afflict so many countries." (Faculty of Physical Education & Health, 2011)

Edited by

Christopher D. Byrne, FRCP, FRCPath, PhD, Institute for Developmental Sciences, Southampton General Hospital, Southampton, UK

Sarah H. Wild, FRCPE, FFPH, PhD, Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK

The Metabolic Syndrome

second edition

The Metabolic Syndrome is a valuable reference text, covering all aspects of the metabolic syndrome and its constituent diseases including inflammation, oxidation and adipocytokines. This book explains the aetiology, pathogenesis and clinical treatment of all risk factors as well as the relationship with diabetes, non-alcoholic fatty liver disease, polycystic ovary syndrome and coronary heart disease.

The Metabolic Syndrome has been further improved from the 1st edition that was highly commended in the 2006 Annual British Medical Association medical book awards. All chapters from the first edition are fully updated and this new edition contains an increase in international contributions and five new chapters on:

• Childhood obesity and metabolic syndrome
• Bariatric surgery for obesity
• Fitness
• Brain insulin resistance and appetite
• The nature of the insulin resistance seen in metabolic syndrome.

This brand new edition of The Metabolic Syndrome will be an indispensable resource for all clinical researchers, physicians and scientists requiring detailed up-to-date information on the metabolic syndrome to further their own research or to treat and manage the syndrome and its complications. Specifically, the text will be of particular relevance to those involved and working in the fields of diabetes, endocrinology, obesity, cardiology, vascular disease and hepatology.

Titles of Related Interest

Obesity and Diabetes, 2nd Edition
Barnett and Kumar, ISBN 9780470519813

Practical Diabetes Care, 3rd Edition
Levy, ISBN 9781444333855

Handbook of Diabetes, 4th Edition
Bilous, ISBN 9781405184090