The Liver in Systemic Disease

A practical guide for non-hepatologists who encounter abnormal liver test results in patients

The Liver in Systemic Disease is an easy-to-use and authoritative guide for non-hepatologist health care professionals who need guidance on the management of patients with abnormal liver tests. The book provides definitive advice for when further investigation, or changes in management, are indicated.

With a practical focus throughout the text, the editors explore when and how to investigate and manage patients whose primary disease is non-hepatic, but whose liver tests are unexpectedly abnormal. The Liver in Systemic Disease provides substantial flow diagrams and advice on the process, together with updates on the liver diseases non-hepatologists are most likely to encounter.

Take-home primers included in the book shine a light on best practice and recommended procedures when dealing with abnormal liver test results. The book also provides:

• A thorough introduction to evaluate the liver, including serum liver tests, liver imaging, and liver biopsy
• Comprehensive discussions of practical issues in patients with liver abnormalities, including the diagnosis of drug induced liver injury, prescribing in patients with abnormal liver tests, and more
• Practical discussions of the management of patients with unexplained abnormal liver tests in primary care
• In-depth examinations of secondary care management of patients with unexplained abnormal liver tests, including intensive care, and the care of infectious and immunosuppressed patients

The Liver in Systemic Disease is an indispensable resource for non-hepatologist medical practitioners seeking to understand the implications of abnormal liver tests and who wish to know when further investigation or alteration of management is indicated.Ein praktischer Leitfaden für Nicht-Hepatologen, die mit abnormen Ergebnissen von Leberuntersuchungen konfrontiert sind.

Das Werk The Liver in Systemic Disease ist ein benutzerfreundlicher, maßgeblicher Leitfaden für Mediziner, die nicht auf Hepatologie spezialisiert sind und Leitlinien für die Behandlung von Patienten mit abnormen Leberwerten benötigen. Das Buch bietet wichtige und konkrete Empfehlungen, wann weitere Untersuchungen oder eine Änderung des Behandlungsplans indiziert sind.

In dem durchgängig praxisnahen Lehrwerk betrachten die Autoren die Frage, wann und wie Patienten untersucht und behandelt werden sollten, deren Grunderkrankung keine Lebererkrankung ist, bei denen jedoch unerwartet abnorme Leberwerte festgestellt werden. Die Inhalte werden überwiegend anhand von Flussdiagrammen und Verfahrenshinweisen dargestellt und enthalten aktuelle Informationen über die Lebererkrankungen, mit denen es Nicht-Hepatologen am ehesten zu tun haben.

Das Buch enthält eine Reihe von Praxistipps, in denen Best Practices und empfohlene Verfahren im Umgang mit abnormen Leberwerten aufgezeigt werden. Darüber hinaus bietet das Werk:
* Eine gründliche Einführung in die Untersuchung der Leber, u.a. mit Serumtests, bildgebenden Verfahren und Leberbiopsie
* Eine umfassende Erörterung der praktischen Probleme mit Patienten, bei denen abnorme Leberwerte auftreten, u.a. in Bezug auf die Diagnose arzneimittelbedingter Leberschäden, die Verschreibung von Medikamenten bei Patienten mit abnormen Leberwerten usw.
* Eine praktische Auseinandersetzung mit der Behandlung von Patienten mit ungeklärten abnormen Leberwerten in der Primärversorgung
* Eine gründliche Betrachtung der Sekundärversorgung von Patienten mit ungeklärten abnormen Leberwerten, u.a. in der Intensivpflege sowie bei der Versorgung infektiöser und immunsupprimierter Patienten

The Liver in Systemic Disease ist ein unverzichtbares Referenzwerk für Mediziner, die nicht auf Hepatologie spezialisiert sind, wenn sie die Auswirkungen abnormer Leberwerte verstehen möchten und wissen möchten, wann weitere Untersuchungen oder eine Änderung des Behandlungsplans indiziert sind.

Preface

Section 1 Introduction

1 Liver Tests

Section 2 Take-Home Primers: Managing The Patient with Unexplained Abnormal Liver Tests

2 Primary Care

Section 3 Take-Home Primers: Managing The Patient With Unexplained Abnormal Serum Liver Tests In Secondary Care

3 Global Perspective

4 Intensive Care

5 Infections Affecting The Liver In Immuno

6 The Post-Operative Patient

7 Pregnancy

8 Endocrinology And Metabolic Diseases (Including Diabetes)

9 Abnormal Serum Liver Tests In Cardiac Disease

10 Respiratory Disease

11 Gastroenterology

12 Renal medicine

13 Dermatology

14 Oncology

15 Haematology

16 Mental health & Neurology

17 Non-alcoholic Fatty Liver Disease (NAFLD)

Section 4 Practical Issues In Patients With Liver Abnormalities

18 Prescribing In Patients With Abnormal Liver Tests Or Liver Disease - A Pragmatic Approach

19 Invasive Procedures In Those With Liver Disease

20 Diagnosing Drug Induced Liver Injury

Index

Gideon M. Hirschfield is a practicing Hepatologist and holds the Lily and Terry Horner Chair in Autoimmune Liver Disease Research at the Toronto General Hospital. He is also Professor of Medicine in the Division of Gastroenterology and Hepatology at the University of Toronto.

Paramjit Gill is a practicing general practitioner and Professor of General Practice at the University of Warwick.

James Neuberger is a consultant physician at Queen Elizabeth Hospital, Birmingham, University Hospitals Birmingham NHS Foundation Trust.

A practical guide for non-hepatologists who encounter abnormal liver test results in patients

The Liver in Systemic Disease is an easy-to-use and authoritative guide for non-hepatologist health care professionals who need guidance on the management of patients with abnormal liver tests. The book provides definitive advice for when further investigation, or changes in management, are indicated.

With a practical focus throughout the text, the editors explore when and how to investigate and manage patients whose primary disease is non-hepatic, but whose liver tests are unexpectedly abnormal. The Liver in Systemic Disease provides substantial flow diagrams and advice on the process, together with updates on the liver diseases non-hepatologists are most likely to encounter.

Take-home primers included in the book shine a light on best practice and recommended procedures when dealing with abnormal liver test results. The book also provides:

• A thorough introduction to evaluate the liver, including serum liver tests, liver imaging, and liver biopsy
• Comprehensive discussions of practical issues in patients with liver abnormalities, including the diagnosis of drug induced liver injury, prescribing in patients with abnormal liver tests, and more
• Practical discussions of the management of patients with unexplained abnormal liver tests in primary care
• In-depth examinations of secondary care management of patients with unexplained abnormal liver tests, including intensive care, and the care of infectious and immunosuppressed patients

The Liver in Systemic Disease is an indispensable resource for non-hepatologist medical practitioners seeking to understand the implications of abnormal liver tests and who wish to know when further investigation or alteration of management is indicated.