The Biology of Disease

All-new edition of a classic textbook bridging the gap between human biology and clinical practice

The Biology of Disease provides a comprehensive overview of the principles of the disease process. Building on the success of previous editions, this all-new Third Edition reflects the unprecedented challenges that the global community now faces in the field, as well as advances in the basic sciences of cell biology, immunology, and the molecular mechanisms of disease, with all chapters extensively modified to ensure that they remain at the cutting edge of current knowledge.

Each section is followed by case studies which bridge the gap between theory and clinical practice. This Third Edition includes 72 case studies in total, of which 34 are new. All diagrams and figures have been updated to present the most relevant information at a glance, and a new companion website with more than 500 multiple choice questions in two difficulty levels has been made available.

Written by three highly qualified academics with significant experience in the field, The Biology of Disease includes information on:

• Emergence of new and drug resistant pathogens and an increasing recognition of the environmental factors, including climate change, that influence health
• The growing impact of diet and physical inactivity on the development of obesity and related disorders including cancer and type 2 diabetes
• Principles of epidemiology, cell reproduction, injury and death, inflammation and disorders of immunity
• Disorders of blood and blood vessels including anaemia, vascular disorders, and disorders of haemostasis

The Biology of Disease is an essential textbook resource for medical students with a focus in physiology, pathophysiology, or pharmacology, along with undergraduate students in biomedical science, biomedicine, medical biochemistry, and human biology.

List of Contributors vii

Contributors to Previous Editions xi

Preface to the Third Edition xiii

Preface to the Second Edition xv

Preface to the First Edition xvii

About the Companion Website xix

Part 1 Basic Principles of Disease and Epidemiology 1

1 The Nature of Disease 3

2 Principles of Epidemiology 11

Part 2 Cell Reproduction, Injury, and Death 29

3 Cell Reproduction, Injury, and Death 31

Part 3 Infectious Diseases 47

4 Infectious Diseases 49

Part 4 Inflammation and Disorders of Immunity 89

5 Inflammation and Repair 91

6 Disorders of the Immune System 109

Part 5 Disorders of Blood and Blood Vessels 155

7 Anaemia 157

8 Disorders of Haemostasis 169

9 Vascular Disorders 181

Part 6 Genetic Disorders 191

10 Genetic Disorders 193

Part 7 Neoplasia 213

11 Neoplasia 215

Part 8 Obesity, Diabetes, and Environmental Diseases 239

12 Nutritional Disorders and Obesity 241

13 Diabetes 257

14 Toxicology and Environmental Diseases 287

Case Studies 301

Answers 537

Appendix 1: Reference Ranges 567

Index 571

Prof. Paul G. Murray, Department of Pathology, Royal College of Surgeons in Ireland-Medical, University of Bahrain. Professor of Molecular Pathology at University of Limerick, Ireland, and Honorary Professor, University of Birmingham, United Kingdom.

Dr. Simon J. Dunmore, Honorary Clinical Senior Lecturer, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen; Honorary Lecturer, Cardiovascular Sciences, School of Medicine, University of Edinburgh; NHS Scotland (Grampian).

Dr. Shantha Perera, Visiting Senior Lecturer, School of Life Sciences, University of Wolverhampton, United Kingdom.

All-new edition of a classic textbook bridging the gap between human biology and clinical practice

The Biology of Disease provides a comprehensive overview of the principles of the disease process. Building on the success of previous editions, this all-new Third Edition reflects the unprecedented challenges that the global community now faces in the field, as well as advances in the basic sciences of cell biology, immunology, and the molecular mechanisms of disease, with all chapters extensively modified to ensure that they remain at the cutting edge of current knowledge.

Each section is followed by case studies which bridge the gap between theory and clinical practice. This Third Edition includes 72 case studies in total, of which 34 are new. All diagrams and figures have been updated to present the most relevant information at a glance, and a new companion website with more than 500 multiple choice questions in two difficulty levels has been made available.

Written by three highly qualified academics with significant experience in the field, The Biology of Disease includes information on:

• Emergence of new and drug resistant pathogens and an increasing recognition of the environmental factors, including climate change, that influence health
• The growing impact of diet and physical inactivity on the development of obesity and related disorders including cancer and type 2 diabetes
• Principles of epidemiology, cell reproduction, injury and death, inflammation and disorders of immunity
• Disorders of blood and blood vessels including anaemia, vascular disorders, and disorders of haemostasis

The Biology of Disease is an essential textbook resource for medical students with a focus in physiology, pathophysiology, or pharmacology, along with undergraduate students in biomedical science, biomedicine, medical biochemistry, and human biology.