Pharmacological Treatment of Alzheimer's Disease

Prominent Alzheimer's investigators provide a comprehensive and balanced overview of the neuropharmacological basis for therapeutics in this devastating disease. Divided into three parts, the book begins with basic research on the neurobiology of cognitive function, offering relevant information on the way the brain encodes and stores data. The second segment explores the molecular aspects of Alzheimer's Disease (AD), emphasizing investigations of possible etiological factors. In the final section, a variety of issues important in developing treatments are discussed including cholinergic-based treatments, the role of neuroinflammin in AD and the therapeutic potential of anti-inflammatory agents.Geboten wird ein vollständiger, ausgewogener Überblick über die neuropharmakologischen Grundlagen von Therapeutika für die Alzheimer-Krankheit. Neueste Untersuchungen molekularer Strukturen und aktuelle klinische Daten werden mit der Verhaltens- und Erkenntnisforschung verknüpft und interpretiert. Partial table of contents:

NEUROBIOLOGY OF COGNITION.

Structure and Dynamics of Multiple Memory Systems in Alzheimer's Disease (R. Kesner & M. Ragozzino).

Monoamine and Acetylcholine Influences on Higher Cognitive Functions in Nonhuman Primates: Relevance to the Treatment of Alzheimer's Disease (A. Arnsten & C. van Dyck).

Neuropsychological Features of Alzheimer's Disease (D. Salmon).

MOLECULAR ASPECTS OF ALZHEIMER'S DISEASE.

Normal Brain Aging and Alzheimer's Disease Pathology (R. Grewal & C. Finch).

Neurofibrillary Tangles in Alzheimer's Disease: Clinical and Pathological Implications (C. Clark, et al.).

ALZHEIMER'S DRUG DISCOVERY AND DEVELOPMENT.

Use of CSF-Based Markers in the Diagnosis of Alzheimer's Disease (P. Seubert, et al.).

Development of Muscarinic Agonists for the Symptomatic Treatment of Alzheimer's Disease (J. Jaen & R. Schwarz).

Conceptual Issues in Research on Inflammation and Alzheimer's Disease (J. Rogers).

Index. I -
The Neurology of Cognition: Structure and Management of Multiple Memory Systems in Alzheimer's Disease;
Interaction of Neuromodulatory Systems Regulating Memory Storage;
Monoamine and Acetylcholine Influences on Higher Cognitive Functions in Nonhuman Primates with Relevance to the Treatment of Alzheimer's Disease;
Cortical Acetylcholine and Attention: Neuropharmacological and Cognitive Principles Directing Treatment Strategies for Cognitive Disorders;
Neuropsychological Features of Alzheimer's Disease;
II -
Neuropathological Features of Alzheimer's Disease;
Normal Brain Ageing and Alzheimer's Disease Pathology;
Recent Developments in the Genetics of Alzheimer's Disease;
Neurofibrillary Tangles in Alzheimer's Disease: Clinical and Pathological Implications;
Amyloid Cytoxicity and Alzheimer's Disease: Roles of Membrane Oxidation and Perturbed Ion Homeostasis;
The Role of Apolipoprotein E in Neurobiology and the Pathogenesis of Alzheimer's Disease;
Animal Models Relevant to Alzheimer's Disease;
III -
Alzheimer's Drug Discovery and Development: Alzheimer's Disease: An International Public Health Problem- Clinical Goals, Strategies and Outcomes;
Use of CSF-based Markers in the Diagnosis of Alzheimer's Disease;
Considerations for Clinical Trials in Alzheimer's Disease;
Cholinesterase Inhibition in the Treatment of Alzheimer's Disease: Further Evaluation of the Clinical Effects of Tucrine;
Development of Muscarinic Agonists for the Symptomatic Treatment of Alzheimer's Disease;
Neuronal Nicotinic Receptors: Potential Treatment for Alzheimer's Disease with Novel Cholinergic Channel Activators;
Neurotrophic Factors: Potential for Therapeutic Intervention in Alzheimer's Disease;
A Fundamental Role for Estrogens in Cognition and Neuroprotection;
Alzheimer's Disease: Prospects for Treatment in the Next Decade.

Jorge D. Brioni and Michael W. Decker are the authors of Pharmacological Treatment of Alzheimer's Disease: Molecular and Neurobiological Foundations, published by Wiley. In recent years, research on Alzheimer's disease has become one of the most intensely pursued areas in the field of neuroscience. Despite the wealth of information gathered, however, relatively little of what has been learned has resulted in the development of effective treatments.

Pharmacological Treatment of Alzheimer's Disease: Molecular and Neurobiological Foundations gathers the top investigators in the area of Alzheimer's research and presents their pioneering work on potential treatments for this devastating disease. Combining current knowledge of the neurobiology of memory with molecular studies related to disease etiology, this book provides a comprehensive review of the latest research on Alzheimer's as well as a thorough examination of current experiments with drugs that could correct the biochemical defects that cause Alzheimer's or ameliorate the associated cognitive deficits. Each of the book's three sections, "Neurobiology of Cognition," "Molecular Aspects of Alzheimer's Disease," and "Alzheimer's Drug Discovery and Development," is a collection of the most recent studies by prominent specialists in their respective fields.

Among the numerous topics covered:
* Structure and dynamics of multiple memory systems in Alzheimer's disease
* Interaction of neuromodulatory systems regulating memory storage
* Neuropsychological features of Alzheimer's disease
* Normal brain aging and Alzheimer's disease pathology
* Recent developments in the genetics of Alzheimer's disease
* Animal models relevant to Alzheimer's disease
* Considerations for clinical trials in Alzheimer's disease
* A fundamental role for estrogens in cognition and neuroprotection
* Alzheimer's disease: prospects for treatment in the next decade.

A comprehensive and balanced overview of the most critically important information available, Pharmacological Treatment of Alzheimer's Disease: Molecular and Neurobiological Foundations heralds a new phase in the process of studying this uniquely human disease: the search for treatments. It is must reading for neuroscientists, pharmacologists, medicinal chemists, and academic physicians involved in basic research and clinical trials, as well as for clinicians who treat Alzheimer's patients.