Fluorine-containing Amino Acids

In recent years, organo-fluorine chemistry has made a marked impacton the design and synthesis of a large variety of biologicallyactive molecules, such as steroids, carbohydrates, amines, aminoacids, peptides and other natural products. Naturally occurringamino acids play a pivotal role in living systems, and thereforesynthetic fluorine-containing amino acids have been of significantinterest to researchers working towards the understanding andmodification of physiological processes. Fluorine-containing AminoAcids:
* is the first volume devoted to the synthesis and properties offluorine-containing amino acids
* pays special attention to the preparation of enantiomericallypure acids (which are essential to the modern pharmaceuticalindustry)
* deals with a rapidly expanding field of research
* has been written by experienced researchers who are responsiblefor many developments in the field
* highlights the interdisciplinary nature of this topic
Fluorine-containing Amino Acids is the only dedicated reference inthis subject and will be essential for researchers in syntheticorganic, peptide, natural product, and medicinal chemistry andbiochemistry. Partial table of contents:

Syntheses of Fluorine-Containing Amino Acids by Methods ofClassical Amino Acid Chemistry (V. Tolman).

Preparation of Fluorine-Containing Amino Acids by Methods ofOrganofluorine Chemistry (V. Kukhar).

Synthesis of Fluorine-Containing Amino Acids by Means ofHomogeneous Catalysis (I. Ojima & Q. Dong).

Synthesis of beta-Fluorine-Containing Amino Acids (N. Sewald &K. Burger).

Asymmetric Synthesis of Fluorine-Containing Amino Acids (V. Kukhar,et.

al).

Enzymatic Synthesis of Fluorine-Containing Amino Acids (Y.Matsumura & M. Urushihara).

Enzymatic Resolution of Racemic Fluorine-Containing Amino Acids (T.Miyazawa).

High-Performance Liquid Chromatography of Fluorine-Containing AminoAcids (S. Galushko).

Renin Inhibitors with Fluorine-Containing Amino Acid Derivatives(H. Sham).

Index.

Valery P. Kukhar is the editor of Fluorine-containing Amino Acids: Synthesis and Properties, published by Wiley. Vadim A. Soloshonok is the editor of Fluorine-containing Amino Acids: Synthesis and Properties, published by Wiley. In recent years, organo-fluorine chemistry has made a marked impact on the design and synthesis of a large variety of biologically active molecules, such as steroids, carbohydrates, amines, amino acids, peptides and other natural products. Naturally occurring amino acids play a pivotal role in living systems, and therefore synthetic fluorine-containing amino acids have been of significant interest to researchers working towards the understanding and modification of physiological processes. Fluorine-containing Amino Acids:

• is the first volume devoted to the synthesis and properties of fluorine-containing amino acids
• pays special attention to the preparation of enantiomerically pure acids (which are essential to the modern pharmaceutical industry)
• deals with a rapidly expanding field of research
• has been written by experienced researchers who are responsible for many developments in the field
• highlights the interdisciplinary nature of this topic

Fluorine-containing Amino Acids is the only dedicated reference in this subject and will be essential for researchers in synthetic organic, peptide, natural product, and medicinal chemistry and biochemistry.