Evidence-Based Infectious Diseases

Written by an international team of authors specializing in microbiology and infectious disease, this new edition of Evidenced-based Infectious Diseases presents practical, up-to-date information on the care of individual patients suffering from infectious diseases. Each chapter addresses a series of focused clinical questions addressed in a systematic fashion, including a comprehensive literature search, and a rating of the quality of evidence using principles of the GRADE framework. Evidence-Based Infectious Diseases is the ideal reference work for all those involved with microbiology, infectious diseases, and clinical management.

List of Contributors vii

Preface xi

1 Introduction to Evidence‐based Infectious Diseases 1
Dominik Mertz, Nick Daneman, and Fiona Smaill

Part 1 Specific Diseases 11

2 Skin and Soft‐tissue Infections 13
Douglas Austgarden and Guilio DiDiodato

3 Bone and Joint Infections 23
Nora Renz and Andrej Trampuz

4 Infective Endocarditis 37
Bahareh Ghadaki and Deborah Yamamura

5 Meningitis and Encephalitis 53
Christopher E. Kandel and Wayne L. Gold

6 Community‐acquired Pneumonia 73
Mark Downing and Jennie Johnstone

7 Healthcare‐associated Pneumonia 81
Jennie Johnstone and Mark Downing

8 Tuberculosis 87
Peter Daley and Marek Smieja

9 Clostridium Difficile Infection in Adults 99
Louis Valiquette

10 Urinary Tract Infections 107
Thomas Fekete

11 Sexually Transmitted Infections 127
Courtney A. Thompson, Darrell H. S. Tan, and Kaede Sullivan

12 Human Immunodeficiency Virus (HIV) 149
Ali Amini, Monique Andersson, Ravindra Gupta, and Brian Angus

13 Hepatitis 181
Lise Bondy and Michael S. Silverman

14 Influenza 193
Ashley Roberts and Joanne M. Langley

15 Critical Care 201
Bram Rochwerg and Jocelyn A. Srigley

Part 2 Special Populations 215

16 Infection Prevention and Control 217
Graham M. Snyder and Eli N. Perencevich

17 Antimicrobial Stewardship 235
Alainna J. Jamal and Andrew M. Morris

18 Infections in Neutropenic Hosts 251
Eric J. Bow

19 Infections in General Surgery 269
Paul A. Moroz and Christine H. Lee

20 Infections in Healthcare Workers 279
Gregory W. Rose

Index 287

Edited by

Dr. Dominik Mertz, Associate Professor, Division of Infectious Diseases, McMaster University and Medical Director, Infection Prevention and Control, Hamilton Health Sciences, Hamilton, Ontario, Canada

Dr. Fiona Smaill, Professor, Department of Pathology and Molecular Medicine, McMaster University and Medical Microbiologist, Hamilton Regional Laboratory Medicine Program, Hamilton, Ontario, Canada

Dr. Nick Daneman, Clinician-Scientist, Division of Infectious Diseases, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada

EVIDENCE-BASED INFECTIOUS DISEASES

THIRD EDITION

An accessible, evidence-based guide to the management of infectious diseases

Now in its Third Edition, Evidence-Based Infectious Diseases draws on the latest and most instructive evidence available to provide healthcare professionals of all levels with a revised and expanded guide to the appropriate management of major infectious diseases. By addressing those issues that clinicians encounter in their daily work, the authors have produced an essential and practical resource, the foundation of which is its case-specific and patient-focused approach. Each chapter systematically works through a set of clinical questions and enhances its insights with a contextualizing literature search, a GRADE assessment of evidence quality, and a breakdown of the benefit–harm ratio of relevant treatment options.

Made up of contributions from an international selection of experts, the book features detailed examinations of specific diseases and disease groups, as well as information on disease control and prevention in special populations. This Third Edition also includes four newly authored chapters, extending its coverage to encompass such key topics as healthcare-associated pneumonia and antimicrobial stewardship. The text:

• Answers everyday clinical questions about the prevention, diagnosis, and management of major infectious diseases
• Supports and illustrates its guidance with recent and relevant evidence
• Looks at case-specific scenarios from a patient-focused perspective
• Features four newly authored chapters
• Contextualizes its content with literature searches, evidence assessments, and benefit–harm ratio reports on treatment options

Evidence-Based Infectious Diseases deftly translates key data into an accessible and highly usable reference guide for all those involved with microbiology, clinical management, and the care and treatment of patients with infectious diseases.