Dendrimers and Other Dendritic Polymers

With contributions from many of the world's leading scientists in the field of dendritic research and development, Dendrimers and Other Dendritic Polymers provides a comprehensive review of this rapidly expanding and exciting new field of polymer science. Of interest to academia and industry alike, this book covers the synthesis, characterization, unique properties, potential for novel applications and technical challenges associated with these polymers.
* Detailed coverage of all known subclasses of dendritic polymers, including their properties and synthesis
* Insight into the potential commercial applications of dendritic polymers, including drug delivery, cancer therapy, coatings and adhesives
* Identification of the key trends and perspectives in dendrimer research
* Essential reference for polymer chemists, materials scientists and plastics engineers working in academia and industry alikeDendrimere (dendritische Polymere) sind Makromoleküle, deren Struktur durch kontrollierte, radial von innen nach außen weisende Verzweigungen gekennzeichnet ist. Dieses spannende, sich rasch entwickelnde Gebiet der Polymerwissenschaft wird hier vorgestellt: Informationen aus erster Hand, von einem der Entdecker der Dendrimere! Der Leser erhält einen umfassenden Einblick in die Eigenschaften, Synthesewege und kommerziellen Verwendungen (u.a. als Vehikel für Wirkstoffe, Bausteine für Nanomaterialien, Spezialbeschichtungen, Klebstoffe und in der Katalyse) der Spezies. Contibutors.

Series Preface.

A Brief Historical Perspective (D.A. Tomalia naad J.M.J. Frecht)

B>I Introduction and Progress in the Control of Macromolecular Architecture

Introduction to the Dendritic State (D.A. Tomalia and J.M. Frechet)

Structure Control of Linear Macromolecules (C.J. Hawker)

Progress in the Branched Architectural State (J. Roovers)

Developments in the Accelerated Convergent Synthesis of Dendrimers (A.W. Freeman and J.M.J. Frechet)

Formation, Structure and Properties of the Crosslinked State Relative to Precursor Architecture (K. Dusek and M. Duskova-Smrckova)

Regioselectively-Crosslinked Nanostructures (C.G. Clark Jr and K. L. Wooley)

Hybridization of Architectural States: Dendritic-linear Copolymer Hybrids (P.R.L. Malenfant and J.M.J. Frechet)

Statistically Branched Dendritic Polymers (E. Malmstrom and A. Hult)

Semi-Controlled Dendritic Structure Synthesis (R.A. Kee et al)

II Characterization of Dendritic Polymers

Gel Electrophoretic Characterization of Dendritic Polymers (C. Zhang and D.A. Tomalia)

Characterization of Dendritically Branched Polymers by Small Angle Neutron Scattering (SANS), Small Angle X-ray Scattering (SAXS), and Transmission Electron Microscopy (TEM) (B.J. Bauer and E.J. Amis)

Atomic Force Microscopy for the Characterization of Dendritic Polymers and Assemblies (J. Li and D.A. Tomalia)

Characterization of Dendrimer Structures by Spectroscopic Techniques (N.J. Turro et al)

Rheology and Solution Properties of Dendrimers (P. Dvornic and S. Uppuluri)

III Properties and Applications of Dendritic Polymers

Dendritic and Hyperbranched Glycoconjugates as Biomedical Anti-Adhesion Agents (R. Roy)

Some Unique Features of Dendrimers based upon Self-assembly and Host-Guest Properties (J. Weener et al)

Dendritic Polymers: Optical and Photchemical Properties (D.L. Jiang and T Aida)

Bioapplications of PAMAM Dendrimers (J.D. Eichman et al)

Dendrimer-Based Biological Reagents: Preparation And Applications in Diagnostics (P. Singh)

Dendritic Polymer Applications: Catalysts (A.W. Kleij et al )

Optical Effects Manifested by PAMAM Dendrimer Metal Nano-Composites (T. Goodson III)

Dendrimers in Nanobiological Devices (S.C. Lee)

Antibodies to PAMAM dendrimers: Reagents for immune detection, patterning and assembly of Dendrimers (S.C. Lee et al)

IV Laboratory Preparation of Dendrimers and Conclusion

Preparation of 'Frechet-type' Polyether Dendrons and Aliphatic Polyester Dendrimers by Convergent Growth: an experimental primer (J.M.J. Frechet et al)

Laboratory Synthesis of Poly(amidoamine) (PAMAM) Dendrimers (R. Esfand and D.A. Tomalia)

Synthesis and Characterization of Poly(Propylene imine) Dendrimers (M.H.P. van Genderen et al)

Laboratory Synthesis and Characterization of Megamers: Core-shell Tecto(dendrimers) (D.A. Tomalia)

Conclusion/Outlook -
Toward Higher Macromolecular Complexity in the Twenty-first Century (D.A. Tomalia and J.M.J. Frechet)

Index "a key work of reference...all serious scientific libraries should acquire a copy." (Reactive & Functional Polymers)

"...this book provides a comprehensive review of this rapidly expanding and exciting new field...no doubt very valuable for both academic and industrial scientists, and deserves to be on the shelves of polymer research labs and institutional libraries." (Polymer News)

"...provides an overview of the field..." (SciTech Book News, Vol. 26, No. 2, June 2002)

"...an excellent introduction...a good reference...will be highly useful..." (Pharmaceutical Research, Vol. 19, No. 12, December 2002)

"...a rich source of information..." (Angewandte Chemie International Edition, Vol. 42, 2003)

Professor Jean M.J. Fréchet, American chemist, is a Professor Emeritus at the University of California, Berkeley.

Donald A. Tomalia is the editor of Dendrimers and Other Dendritic Polymers, published by Wiley.

Dendrimers have been referred to as "the polymers of the 21st Century." These macromolecules are characterized by "branch upon branch" architecture and are now rapidly expanding the general fields of polymer science and chemistry. Dendritic polymers are the most recently discovered, fourth major architectural class of macromolecules. They represent a fourth major class after traditional types which include (I) linear, (II) cross-linked and (III) branched architectures.

Dendrimers and Other Dendritic Polymers provides a detailed insight into dendritic polymers, and discusses all the known subclasses of dendritic polymers in addition to dendrons and dendrimers, including hyperbranched polymers, dendrigrafts and megamers.

Dendrimers possess unique structures and exhibit properties that differ dramatically from those of the more traditional polymer types. These features have contributed to multi-disciplinary applications and now many major chemical companies are investing extensively in dendritic polymer research as they are investigating their broad commercial applications. They are currently being developed for use in the pharmaceutical and chemical industries with identified applications in areas as diverse as: drug delivery, cancer therapy, nano-pharmaceuticals, nano-diagnostics, nanolithography, coatings and adhesives, separation technology and catalysis.

With contributions from many of the leading scientists in the field of dendritic polymers, this comprehensive volume provides:
* an overview of developments in the field of dendrimers, with a comparison of properties and synthesis to traditional polymers

* discussion of commercial and potential applications for dendritic polymers

* an identification of the key trends and analytical perspectives in dendrimer research

* practical procedures for the laboratory preparation of some of the more commonly used dendrimer families.
This will be essential reading for all chemists, polymer/material scientists, plastics engineers, nanotechnologists and postgraduate polymer scientists and engineers.