Bioorganic Chemistry

The understanding of (patho)physiological processes - the biosynthesis of biomolecules such as enzymes, nucleic acids, and secondary metabolites; the pathways of signaltransduction; or the function of pharmaceutical agents - is of increasing importance not only for drug research but also for the development of new synthetic methods in organic chemistry and biochemistry. In a truly interdisciplinary way bioorganic chemistry unites the central questions of biochemistry, medicinal chemistry, organic chemistry, and spectroscopy.
This book fills a void in this rapidly growing field of chemistry and gives a thorough yet understandable introduction for advanced students and researchers alike. Contributions of more than sixty scientists provide a topical overview of recent advances in: drug development based on natural products; the biosynthesis, activity, and application of enzymes; carbohydrates; peptides; nucleic acids; analytical methods in bioorganic chemistry.
This book will be an appetizer for all - students and researchers alike - seeking orientation in this fascinating field of chemistry.

Das Verständnis (patho)physiologischer Prozesse - der Biosynthese von Enzymen, Nukleinsäuren, Sekundärmetaboliten und anderen Biomolekülen, der intrazellulären Signalübertragung oder der Wirkungsweise von Medikamenten - ist nicht nur für die Wirkstoffsuchforschung von wachsender Bedeutung sondern generell für die Entwicklung neuer Synthesemethoden in der organischen Chemie. Die bioorganische Chemie geht in interdisziplinärer Weise diesen zentralen Fragen von Biochemie, medizinischer, organischer und analytischer Chemie nach.

Diese verständliche und informative Einführung richtet sich an fortgeschrittene Studenten und bereits auf dem Gebiet arbeitende Chemiker gleichermaßen und füllt damit eine Lücke in den Publikationen zur bioorganischen Chemie. Die Beiträge von mehr als sechzig Wissenschaftlern geben einen ausgewogenen Überblick über den aktuellen Stand der Forschung auf den Gebieten der Wirkstoffentwicklung auf Basis von Naturstoffen, der Biosynthese, Aktivität und Anwendung von Enzymen, Kohlehydraten, Peptiden und Nukleinsäuren sowie dem Einsatz analytischer Methoden in der Bioorganik.

DRUGS AND SEARCH FOR LEAD STRUCTURES
Marine Alkaloids
Leukotriene Derivates
Diazoketones for the Synthesis of Beta-Lactams
Selenium Compounds in Biochemical Oxidations
Galaktophingolipid, etc
ENZYMOLOGY
Enzyme Catalyzed Diels-Alder Reactions
Enzymatic Halogenation in Bacteria
Biotransformations in the Stereoselective Synthesis of Cyclophanes, etc
CARBOHYDRATES
Mannosid Clusters
Glycoconjugates in Cancer Therapy, etc
PEPTIDES
Cyclodepsipeptides
Synthetic Adrenaline and Peptide Receptors
Substituted and Beta-Amino Acids as Building Blocks for Peptide Mimetics
Carbohydrate-Protein Interactions, etc.
NUCLEIC ACIDS
Reparing Dna
In Vitro Selection
Studies on Hairpin Ribozymes
New Pna Buiding Block for Antisense Research, etc.
BIOCHEMISTRY
Activity of Neuropeptide Y
Oligosaccharide Antibiotics
Biosynthesis of Plant Xanthones
Manipulating Intracellular Signal Transductions
Methyl-Transfer Reactions, etc.
SYNTHETIC AND ANALYTICAL METHODS
Constitutional Assignment of Marine Natural Products
Radical Induced Reactions in Biological Systems
Multivariate Analysis of Biotransformations, etc. Rezensionen:
"...bietet dieses Buch einen guten Überblick und Einstieg sowohl von chemischer als auch von biologischer Seite...Für alle, die Interesse an spannenden neuen Themen wie enzymatische Diels-Alder Reaktionen oder die Synthese von Oligonucleotiden mit Polypeptid Rückgrat anstatt des Zucker/Phosphat Rückgrats werden an diesem Buch ihre Freude haben." KVV d. Fachschaft Biologie-und Chemiewissenschaften Potsdam

>Ulf Diederichsen studied Chemistry in Freiburg, Germany, with a diploma work in organic synthesis and completed his Ph.D. in 1993 under the supervision of Albert Eschenmoser at the ETH Zürich working on homo- and glucose-DNA. Following postdoctoral work on radical chemistry at the University of Pittsburgh, USA, in the group of Dennis Curran, he gained his habilitation at the Technical University Munich, Germany, with Horst Kessler as mentor. In 1999, he was appointed professor of Organic Chemistry at the University Würzburg, Germany, until joining the Georg-August-University in Göttingen, Germany, in 2001 as full professor of Organic Chemistry. He was visiting professor at the LMU Munich and Goering Visiting Professor at the University of Wisconsin, USA. In 1999 he got the Karl Winnacker stipend and Hellmut-Bredereck award and is an ordinary member of Göttingen Academy of Sciences and Humanities since 2012 Bioorganic Chemistry Highlights and New Aspects Edited by U. Diederichsen, T.K. Lindhorst, B. Westermann, and L.A. Wessjohann The understanding of (patho) physiological processes — the biosynthesis enzymes, nucleic acids, and secondary metabolites; the pathways of signaltransduction or the function of pharmaceutical agents — is of increasing importance not only in drug research but also for the development of new synthetic methods in organic chemistry and biochemistry. In a truly interdisciplinary way, bioorganic chemistry unites the central questions of biochemistry, medicinal chemistry, and organic chemistry. This book fills a void in this rapidly growing field of chemistry and gives a thorough yet understandable introduction for advanced students and researches alike. Contributions of more than sixty scientists provide a topical overview of recent advances in drug development based on natural products; the biosynthesis, activity, and application of enzymes; carbohydrates; peptides; nucleic acids, and analytical methods in bioorganic chemistry. This book will be an appetizer for all — students and researchers alike — seeking orientation in this fascinating field of chemistry.