Principles Of Bioinorganic Chemistry

A concepts-orientated introduction to bioinorganic chemistry covering topics including: properties of biological molecules; physical methods in bioinorganic chemistry; control and utilization of metal ion concentrations in cells, and electron transfer proteins.

As one of the most dynamic fields in contemporary science, bioinorganic chemistry lies at a natural juncture between chemistry, biology, and medicine. This rapidly expanding field probes fascinating questions about the uses of metal ions in nature. Respiration, metabolism, photosynthesis, gene regulation, and nerve impulse transmission are a few of the many natural processes that require metal ions, and new systems are continually being discovered. The use of unnatural metals - which have been introduced into human biology as diagnostic probes and drugs - is another active area of tremendous medical significance.

This introductory text, written by two pioneering researchers, is destined to become a landmark in the field of bioinorganic chemistry through its organized unification of key topics. Accessible to undergraduates, the book provides necessary background information on coordination chemistry, biochemistry, and physical methods before delving into topics that are central to the field: What metals are chosen and how are they taken up by cells? How are the concentrations of metals controlled and utilized in cells? How do metals bind to and fold biomolecules? What principles govern electron transfer and substrate binding and activation reactions? How do proteins fine-tune the properties of metals for specific functions? For each topic discussed, fundamentals are identified and then clarified through selected examples. An extraordinarily readable writing style combines with chapter-opening principles, study problems, and beautifully rendered two-color illustrations to make this book an ideal choice for instructors, students, and researchers in the chemical, biological, and medicalcommunities.

Translated into French, German, Japanese, Polish and Chinese.l. Overview
2. Principles of Coordination Chemistry Related to Bioinorganic Research
3. Properties of Biological Molecules
4. Physical Methods in Bioinorganic Chemistry
5. Choice, Uptake and Assembly of Metal Containing Units in Biology
6. Control and Utilization of Metal-Ion Concentrations in Cells
7. Metal Ion Folding and Cross-Linking of Biomolecules
8. Binding of Metal Ions and Complexes to Biomolecule-Active Centers
9. Electron-Transfer Proteins
10. Substrate Binding and Activation by Nonredox Mechanisms
11. Atom- and Group-Transfer Chemistry
12. Protein Tuning of Metal Properties to Achieve Specific Functions
13.The Frontiers of Bioinorganic Chemistry
Index"A splendid introduction to bioinorganic chemistry. The excellent illustrations complement their lucid and stimulating account of basic principles." --Lubert Stryer, Stanford

"…an important contribution to the understanding of biochemical systems." --Cell Biochemistry and Function

"Lippard and Berg’s book should be very useful at academic institutions offering coursework in bioinorganic chemistry. Their style of writing and the book’s format are perfect for that audience." --Science and Technology

"The best textbook to date…it is essential reading for anyone interested in learning more about this fascinating field." --Science